Significance of Anti-deoxyribonuclease-B(ADN-B)Determination in Clinical Practice : THE 6th CONFERENCE ON PREVENTION FOR RHEUMATIC FEVER AND RHEUMATIC HEART DISEASE
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概要
- 論文の詳細を見る
The determination of anti-deoxyribonuclease-B (ADN-B) is very important for the diagnosis of antecedent streptococcal infection because almost all of group A streptococci have this antigen and a strong elevation of the antibody is observed in patients with acute rheumatic fever, acute glomerulonephritis and other streptococcal infections. Moreover, ADN-B titers are elevated in cases with streptococcal skin infection, whereas anti-streptolysin O (ASO) titers are rarely elevated in these cases. So the determination of ADN-B is recommended as the second streptococcal antibody test to ASO detection (manual of WHO). In our study, the upper limits of ADN-B in normal subjects were 1 : 60 in preschool age, 1 : 480 in school age and 1 : 340 in adult age groups. In acute rheumatic fever, ADN-B titers were elevated in 87% of the cases and also 87% of the patients with acute glomerulonephritis had high ADN-B titers. In inactive rheumatic fever, 72% of the patients had high ADN-B titers, while, ASO titers were elevated in only 22% of the cases. In streptococcal carrier states, 39% of the children had high ADN-B titers but ADN-B was positive only 8% in non-carrier children.
- 社団法人日本循環器学会の論文
- 1982-11-20
著者
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Watanabe Nobuo
Department of Applied Biological Science, Faculty of Science and Technology, Tokyo University of Sci
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KAWAKITA SEIICHI
Department of Cardiology, Tenri Hospital
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YAMADA Toshihiko
Department of Gastroenterology, Maebashi Red Cross Hospital
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OHKUNI Masahiko
Department of Pediatrics, School of Medicine, Nihon University
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Kawakita Seiichi
Department Of Cardiology Tenri Hospital
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Oda Teiichi
Department Of Pediatrics Faculty Of Medicine Kyushu University
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Oda Teiichi
Department Of Pediatrics Fukuoka University
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Kawakita Seiichi
Department Of Internal Medicine Shiga University Of Medical Science
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FUJIKAWA SATOSHI
Department of Pediatrics, Tokyo Kyosai Hospital
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KOSAKAI NOZOMI
Department of Clinical Pathology, Juntendo University
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SHIOKAWA YUICHI
Department of Internal Medicine, Juntendo University
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Shiokawa Yuichi
Department Of Cardiovascular Surgery Graduate School Of Medical Sciences Kyushu University
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Ohkuni Masahiko
Department Of Pediatrics Nihon University
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Fujikawa Satoshi
Department Of Pediatrics Dokkyo Medical School Koshigaya Hospital
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Fujikawa Satoshi
Department Of Pediatrics Tokyo Kyosai Hospital
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Kosakai Nozomi
Department Of Clinical Pathology Juntendo University
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Shiokawa Yuichi
Department Of Internal Medicine Juntendo University
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Fujikawa Satoshi
Department Of Pediatrics Dokkyo Koshigaya Hospital
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Watanabe Nobuo
Department Of Pediatrics Kyorin University
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Yamada Toshihiko
Department Of Clinical Pathology Juntendo University School Of Medicine
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Yamada Toshihiko
Department Of Microbiology Yamanashi Medical School
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