Synthesis and Biological Activities of Neoechinulin A Derivatives : New Aspects of Structure-Activity Relationships for Neoechinulin A
スポンサーリンク
概要
- 論文の詳細を見る
We synthesized a series of neoechinulin A derivatives and examined the structure-activity relationships in terms of their anti-nitration and anti-oxidant activities as well as their cytoprotective activity against peroxynitrite from SIN-1 (3-(4-morpholinyl)sydnonimine hydrochloride) using PC12 cells. Our results showed that the C-8/C-9 double bond, which constitutes a conjugate system with indole and diketopiperazine moieties of neoechinulin A is essential for anti-nitration and anti-oxidant activities as well as protection against SIN-1 cytotoxicity. The presence of an intact diketopiperazine moiety is an additional requirement for anti-nitration activity but not for the cytoprotective action. Our results suggest that the antioxidant activity or electrophilic nature of the C-8 carbon, both of which are afforded by the C-8/C-9 double bond, may play a role in the cytoprotective properties of this alkaloid.
- 公益社団法人日本薬学会の論文
- 2008-12-01
著者
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ARAI Takao
Department of Neurosurgery, Jikei University School of Medicine Kashiwa Hospital
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Takeuchi Toshifumi
Department of Applied Biological Science, Tokyo University of Science
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SUGAWARA Fumio
Department of Applied Biological Science, Tokyo University of Science
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Kuramochi Kouji
Department of Pharmaceutical Sciences, Tokyo University of Science
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Watanabe Nobuo
Department of Applied Biological Science, Faculty of Science and Technology, Tokyo University of Sci
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Saitoh Yoshihiko
Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine
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Aoki Toshiaki
Department Of Pharmaceutical Sciences Tokyo University Of Science
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Kobayashi Susumu
Department Of Pharmaceutical Sciences Tokyo University Of Science
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Saitoh Yoshihiko
Department Of Applied Biological Science Tokyo University Of Science
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Sugawara F
Dep. Of Applied Biological Sci. Tokyo Univ. Of Sci.
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NAKAZAKI Atsuo
Faculty of Pharmaceutical Sciences, Tokyo University of Science
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OHNISHI Kensuke
Genome and Drug Discovery Center, Tokyo University of Science
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FUJIEDA Satoshi
Department of Applied Biological Science, Tokyo University of Science
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NAKAJIMA Mitsuhiro
Department of Applied Biological Science, Tokyo University of Science
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KOBAYASHI Susumu
Genome and Drug Discovery Center, Tokyo University of Science
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Arai Takao
Department Of Applied Biological Science Faculty Of Science And Technology Tokyo University Of Scien
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Arai T
Department Of Applied Biological Science Faculty Of Science And Technology Science University Of Tok
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Sugawara Fumio
Dep. Of Applied Biological Sci. Tokyo Univ. Of Sci.
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Sugawara Fumio
Department Of Agricultural Chemistry Faculty Of Agriculture Tohoku University
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Nakazaki Atsuo
Faculty Of Pharmaceutical Sciences Tokyo University Of Science
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Kobayashi S
Department Of Clinical Pharmacology Faculty Of Pharmaceutical Sciences Hokuriku University:organizat
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Fujieda Satoshi
Department Of Applied Biological Science Tokyo University Of Science
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Ohnishi Kensuke
Genome And Drug Discovery Center Tokyo University Of Science:faculty Of Pharmaceutical Sciences. Tok
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Nakajima Mitsuhiro
Department Of Applied Biological Science Tokyo University Of Science
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Kuramochi Kouji
Department Of Applied Biological Chemistry The University Of Tokyo
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Sugawara Fumio
Dep. Of Applied Biological Sci. Fac. Of Sci. And Technol. Tokyo Univ. Of Sci.
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Arai Takao
Department Of Applied Biological Science Faculty Of Science And Technology Science University Of Tok
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Watanabe Nobuo
Dep. Of Applied Biological Sci. Fac. Of Sci. And Technol. Tokyo Univ. Of Sci.
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Nakazaki Atsuo
Fac. Of Pharmaceutical Sciences Tokyo Univ. Of Sci. (rikadai)
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Takeuchi Toshifumi
Department of Applied Biological Science, Faculty of Science and Technology, Tokyo University of Science
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