Novel Terpenoids, Trichoderonic Acids A and B Isolated from Trichoderma virens, Are Selective Inhibitors of Family X DNA Polymerases
スポンサーリンク
概要
- 論文の詳細を見る
Trichoderonic acids A (1) and B (2), novel terpenoids, and (+)-heptelidic acid (3) isolated from cultures of a fungus, Trichoderma virens, and their structures were identified by spectroscopic analysis. These compounds selectively and competitively inhibited the activities of mammalian DNA polymerases β, λ (pols β, λ), and terminal deoxynucleotidyl transferase (TdT) in family X of pols, and compound 2 was a stronger inhibitor than compound 1 or 3. On the other hand, compounds 1–3 did not influence the activities of the other families (A-, B-, and the Y-families) of the mammalian pols tested, and showed no effect on the activities of plant pol α, fish pol δ, prokaryotic pol, or the other DNA metabolic enzymes tested. Compound 2 suppressed the growth of two human cancer cell lines, cervix carcinoma cells (HeLa) and breast carcinoma cells (MCF-7). The results suggest that these compounds identified inhibition among the families of mammalian pols.
- 社団法人 日本農芸化学会の論文
- 2010-04-23
著者
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Yamaguchi Yasuhiro
Department of Applied Biological Science, Tokyo University of Science
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Manita Daisuke
Department of Applied Biological Science, Tokyo University of Science
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Takeuchi Toshifumi
Department of Applied Biological Science, Tokyo University of Science
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KURAMOCHI Kouji
Graduate School of Life and Environmental Science, Kyoto Prefectural University
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KURIYAMA Isoko
Laboratory of Food & Nutritional Sciences, Department of Nutritional Science, Kobe-Gakuin University
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SUGAWARA Fumio
Department of Applied Biological Science, Tokyo University of Science
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YOSHIDA Hiromi
Laboratory of Food & Nutritional Sciences, Department of Nutritional Science, Kobe-Gakuin University
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MIZUSHINA Yoshiyuki
Laboratory of Food & Nutritional Sciences, Department of Nutritional Science, Kobe-Gakuin University
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Yoshimura Hidetoshi
Faculty Of Pharmaceutical Sciences Kyushu University(present):department Of Food And Nutrition Nakam
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Sugawara F
Dep. Of Applied Biological Sci. Tokyo Univ. Of Sci.
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Sugawara Fumio
Dep. Of Applied Biological Sci. Tokyo Univ. Of Sci.
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Sugawara Fumio
Department Of Agricultural Chemistry Faculty Of Agriculture Tohoku University
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Yoshida H
Lab. Of Food & Nutritional Sciences Dep. Of Nutritional Sci. Kobe-gakuin Univ.
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Kuramochi Kouji
Graduate School Of Life And Environmental Sci. Kyoto Prefectural Univ.
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Kuriyama Isoko
Lab. Of Food & Nutritional Sciences Dep. Of Nutritional Sci. Kobe-gakuin Univ.
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Yoshimura H
Faculty Of Pharmaceutical Sciences Kyushu University(present):department Of Food And Nutrition Nakam
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Mizushima Y
Laboratory Of Food And Nutritional Sciences Department Of Nutritional Science Kobe-gakuin University
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Mizushina Y
Kobe‐gakuin Univ. Kobe Jpn
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Mizushina Yoshiyuki
Department Of Nutritional Science Kobe Gakuin University
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Manita Daisuke
Department Of Applied Biological Science Tokyo University Of Science
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Yamaguchi Yasuhiro
Department Of Agricultural Biochemistry And Biotechnology Tottori University
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Yamaguchi Yasuhiro
Department Of Applied Biological Science Tokyo University Of Science
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Sugawara Fumio
Dep. Of Applied Biological Sci. Fac. Of Sci. And Technol. Tokyo Univ. Of Sci.
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Takeuchi Toshifumi
Department of Applied Biological Science, Faculty of Science and Technology, Tokyo University of Science
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吉村 英敏
Department of Nutritional Science, Kobe Gakuin University
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Mizushina Yoshiyuki
Laboratofy of Food & Nutritional Sciences, Department al Nutritional Science, and High Technology Research Center, Kobe-Colmar University
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