The Antinociceptive and Anti-inflammatory Action of the CHCl3-Soluble Phase and Its Main Active Component, Damnacanthal, Isolated from the Root of Morinda citrifolia

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概要

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• Morinda citrifolia (Rubiaceae, Noni) is a traditional medicine with various pharmacological activities. We investigated if the MeOH-, CHCl3- and BuOH-soluble phase and its main active component, damnacanthal, isolated from the Noni root, have antinociceptive and anti-inflammatory actions in mice. The CHCl3-soluble phase (3 g/kg, per os (p.o.)) significantly reduced pain-related behavior observed in the formalin test. These effects were not suppressed by pretreatment with naloxone (1 mg/kg, intraperitoneally (i.p.)), an opioid receptor antagonist. The CHCl3-soluble phase (3 g/kg, p.o.) significantly reduced histamine-induced paw edema. The MeOH- and BuOH-soluble phase had no effect in either test. Furthermore, damnacanthal (10—100 mg/kg, p.o.) exerted an antinociceptive effect on chemical nociceptive stimuli, and decreased histamine-induced paw edema. Damnacanthal was weakly bound to the histamine H1 receptor. These data suggest that the CHCl3-soluble phase of the Noni root has antinociceptive and anti-inflammatory effects. Furthermore, these effects of damnacanthal isolated from the Noni root is mediated in part by the histamine H1 receptor.

著者

• MIZUSHINA Yoshiyuki

  Laboratory of Food & Nutritional Sciences, Department of Nutritional Science, Kobe-Gakuin University

• Nakamoto Kazuo

  Department of Clinical Pharmacy, Kobe Gakuin University, School of Pharmaceutical Sciences

• Fujita-Hamabe Wakako

  Department of Clinical Pharmacy, Kobe Gakuin University, School of Pharmaceutical Sciences

• Tokuyama Shogo

  Department of Clinical Pharmacy, Kobe Gakuin University, School of Pharmaceutical Sciences

• Okusada Kanako

  Department of Clinical Pharmacy, School of Pharmaceutical Sciences, Kobe Gakuin University

• Nishida Mikako

  Department of Clinical Pharmacy, School of Pharmaceutical Sciences, Kobe Gakuin University

• Kamiya Kohei

  Department of Pharmacognosy and Natural Product Chemistry, School of Pharmaceutical Sciences, Kobe G

• Satake Toshiko

  Department of Pharmacognosy and Natural Product Chemistry, School of Pharmaceutical Sciences, Kobe G

• Kamiya Kohei

  Department Of Pharmacognosy And Natural Product Chemistry Faculty Of Pharmaceutical Sciences Kobe Ga

• Satake Toshiko

  Department Of Pharmacognosy And Natural Product Chemistry Faculty Of Pharmaceutical Sciences Kobe Ga

• Tokuyama Shogo

  Department Of Clinical Pharmacy Kobe Gakuin University Faculty Of Pharmaceutical Sciences

• Fujita-Hamabe Wakako

  Department of Clinical Pharmacy, School of Pharmaceutical Sciences, Kobe Gakuin University

• NAKAMOTO Kazuo

  Department of Clinical Pharmacy, School of Pharmaceutical Sciences, Kobe Gakuin University

• Nakamoto Kazuo

  Department of Chemistry, Faculty of Science, Osaka University

• Mizushina Yoshiyuki

  Laboratory of Food and Nutritional Sciences, Department of Nutritional Sciences, Kobe Gakuin University

• Kamiya Kohei

  Department of Pharmacognosy and Natural Product Chemistry, School of Pharmaceutical Sciences, Kobe Gakuin University

• Satake Toshiko

  Department of Pharmacognosy and Natural Product Chemistry, School of Pharmaceutical Sciences, Kobe Gakuin University

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