Regulatory Action of Nitric Oxide Synthase on Ileal P-glycoprotein Expression under Streptozotocin-Induced Diabetic Condition
スポンサーリンク
概要
- 論文の詳細を見る
P-glycoprotein (P-gp), a drug efflux transporter, affects the pharmacokinetics of a wide range of substrate drugs. Our previous study clearly revealed that intestinal P-gp expression levels were decreased via an inducible nitric oxide synthase (iNOS)-mediated mechanism in the early phases of diabetes. Here, we focused on changes in ileal P-gp expression and the influences of NOS on the P-gp expression levels in the later phase of diabetic condition using streptozotocin (STZ)-induced diabetic mice. The ileal P-gp expression and activity was analyzed by Western blot analysis and by in situ closed loop method, respectively. In STZ-treated mice, ileal P-gp expression levels and activity significantly decreased on the 9th day after STZ administration. Interestingly, the decrease of P-gp function was recovered to the control level on 15th day in same conditioned mice. In addition, the recovery of P-gp expression levels was completely suppressed by a non-selective NOS inhibitor. These results indicate that the diabetic condition-induced decline of P-gp expression levels was temporary, and both decline- and recovery-process of intestinal P-gp expression levels are mediated by NOS. Furthermore, this study shows the bidirectional effect of NOS on regulation of intestinal P-gp expression.
- 日本薬学会の論文
著者
-
Fujita-Hamabe Wakako
Department of Clinical Pharmacy, Kobe Gakuin University, School of Pharmaceutical Sciences
-
Tokuyama Shogo
Department of Clinical Pharmacy, Kobe Gakuin University, School of Pharmaceutical Sciences
-
Tokuyama Shogo
Department Of Clinical Pharmacy Kobe Gakuin University Faculty Of Pharmaceutical Sciences
-
Nawa Ayaka
Department of Clinical Pharmacy, School of Pharmaceutical Sciences, Kobe Gakuin University
関連論文
- Antinociceptive Effects of Docosahexaenoic Acid against Various Pain Stimuli in Mice
- Preventive Effect of Morinda citrifolia Fruit Juice on Neuronal Damage Induced by Focal Ischemia(Pharmacognosy)
- The Antinociceptive and Anti-inflammatory Action of the CHCl3-Soluble Phase and Its Main Active Component, Damnacanthal, Isolated from the Root of Morinda citrifolia
- Effect of Orexin-A on Post-ischemic Glucose Intolerance and Neuronal Damage
- Involvement of Adenosine A_2 Receptors in the Changes of Tissue Factor-Dependent Coagulant Activity Induced by Polymorphonuclear Leukocytes in Endothelial Cells
- Induction and Inhibition of Cytochrome P450 and Drug-Metabolizing Enzymes by Climbazole
- CLIMBAZOLE IS A NEW POTENT INDUCER OF RAT HEPATIC CYTOCHROME P450
- Changes of Tissue Factor-Dependent Coagulant Activity Mediated by Adhesion Between Polymorphonuclear Leukocytes and Endothelial Cells
- Effect of 4-(4-Chlorobenzyl)pyridine on Rat Hepatic Microsomal Cytochrome P450 and Drug-Metabolizing Enzymes in Vivo and in Vitro
- SEX-RELATED EFFECT OF HEMIN ON CYTOCHROME P450 AND DRUG-METABOLIZING ENZYMES IN RAT LIVER
- Antigenic characterization in ampiroxicam-induced photosensitivity using an in vivo model of contact hypersensitivity
- Regulatory Action of Nitric Oxide Synthase on Ileal P-glycoprotein Expression under Streptozotocin-Induced Diabetic Condition
- A Potent Mu-Opioid Receptor Agonist, Dihydroetorphine, Fails to Produce the Conditioned Place Preference in Mice
- Antinociceptive Effect of Dihydroetorphine Following Various Routes of Administration : a Comparative Study with Morphine
- Morinda citrifolia fruit juice prevents ischemic neuronal damage through suppression of the development of post-ischemic glucose intolerance
- Participation of GABAergic Systems in the Production of Antinociception by Various Stresses in Mice
- Unsaturated Fatty Acids and Pain
- Negative Relationship Between Morphine Analgesia and P-Glycoprotein Expression Levels in the Brain
- Further Evidence for the Participation of an α_2-Adrenoceptor Mediated Mechanism in the Production of Forced Swimming-Stress Induced Analgesia in Mice
- PARTICIPATION OF AN α2-MEDIATED MECHANISM IN THE PRODUCTION OF FORCED SWIMMINGSTRESS INDUCED ANALGESIA IN MICE
- The Opioid Activity and Receptor Selectivity of Fluorinated Leu^5 Enkephalin Analogues in Vitro and in Vivo
- Neurosteroids stimulate G protein-coupled sigma receptors in mouse brain synaptic membrane
- Effect of Orexin-A on Post-ischemic Glucose Intolerance and Neuronal Damage
- Ameliorating Effect of Hypothalamic Brain-Derived Neurotrophic Factor Against Impaired Glucose Metabolism After Cerebral Ischemic Stress in Mice
- Ischemic Stroke and Glucose Intolerance : a Review of the Evidence and Exploration of Novel Therapeutic Targets
- The Involvement of Cleavage of Neural Cell Adhesion Molecule in Neuronal Death under Oxidative Stress Conditions in Cultured Cortical Neurons
- Honokiol suppresses the development of post-ischemic glucose intolerance and neuronal damage in mice
- Functional Alterations of Intestinal P-Glycoprotein under Diabetic Conditions
- Distinctive implication of emotional factors in various types of stress-induced analgesia.
- Radixin Influences the Changes in the Small Intestinal P-Glycoprotein by Etoposide Treatment
- Blockade by Ginseng Extract of the Development of Reverse Tolerance to the Ambulation-Accelerating Effect of Methamphetamine in Mice.
- Further evidence for the implication of a .KAPPA.-opioid receptor mechanism in the production of psychological stress-induced analgesia.
- Anti-Stress Effect of Ginseng on the Inhibition of the Development of Morphine Tolerance in Stressed Mice.
- Blockade of the development of analgesic tolerance to morphine by psychological stress through benzodiazepine receptor mediated mechanism.
- Involvement of Serotonergic Receptor Subtypes in the Production of Antinociception by Psychological Stress in Mice.