Further Evidence for the Participation of an α_2-Adrenoceptor Mediated Mechanism in the Production of Forced Swimming-Stress Induced Analgesia in Mice

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概要

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• Subanalgesic dose, 0.01 to 0.25 mg/kg, of clonidine (CLO), an α_2-adrenoceptor agonist, potentiated forced swimming (SW) stress induced analgesia (SIA) and suppressed psychological (PSY)-SIA in a dose dependent manner but did not affect foot-shock (FS)-SIA. Daily exposure to each stress rapidly developed tolerance, and the development was suppressed by daily concomitant subanalgesic dose of CLO in SW-SIA but not in FS- and PSY-SIA. Meanwhile, SW-stress, applied after injection of CLO, 1 mg/kg, potentiated the analgesic effect of CLO and suppressed the development of tolerance to the effect. On the other hand, FS- and PSY-stress did not affect CLO analgesia and failed to block the tolerance development. These results provide further evidence that α_2-adrenergic mechanism is involved in the production of SW-SIA.

• 公益社団法人日本薬学会の論文

著者

• Tokuyama S

  長崎大学 薬 分子薬理

• Tokuyama Shogo

  Department Of Clinical Pharmacy Kobe Gakuin University Faculty Of Pharmaceutical Sciences

• KANETO Hiroshi

  Department of Pharmacology, Faculty of Pharmaceutical Sciences, Nagasaki University

• KANETO Hiroshi

  Emeritus Professor, Nagasaki University

• Takahashi M

  Department Of Pharmacology Faculty Of Pharmaceutical Sciences Nagasaki University

• Takahashi Masakatsu

  Department Of Pharmacoinformatics School Of Pharmaceutical Sciences Nagasaki University

• Kaneto H

  Department Of Pharmacology Faculty Of Pharmaceutical Sciences Nagasaki University

• Kaneto Hiroshi

  Department Of Pharmacology Faculty Of Pharmaceutical Science Nagasaki University

• Takahashi Masakatsu

  Department of Analytical Research for Pharmacoinformatics, Graduate School of Pharmaceutical Sciences, Nagasaki University

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