BRAIN LEVEL OF PENTOBARBITAL IS THE PRIMARY DETERMINANT FOR THE DEVELOPMENT OF HYPNOTIC TOLERANCE IN MICE
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概要
- 論文の詳細を見る
Controlling the duration of hypnotic effect of pentobarbital by simultaneously administered bemegride, the relationship between the duration of hypnosis and the degree of developed tolerance after acute or chronic treatment was investigated in mice. Bemegride attenuated the hypnotic effect of pentobarbital, but neither the brain level of pentobarbital nor the development of tolerance was modified by bemegride, indicating that the brain level of pentobarbital is the primary determinant for the production of tolerance and full duration of hypnosis is not essential in this mechanism.
- 公益社団法人日本薬学会の論文
著者
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TAGUCHI Junichi
Department of Cardiology, Tokai University Hachioji Hospital
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KANETO Hiroshi
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Nagasaki University
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Taguchi Junichi
Department Of Cardiology Tokai University Hachioji Hospital
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Taguchi Junichi
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Nagasaki University
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Kaneto Hiroshi
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Nagasaki University
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Kaneto Hiroshi
Department Of Pharmacology Faculty Of Pharmaceutical Science Nagasaki University
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