Differential Roles of the Adrenal Gland in the Suppression of Morphine Antinociceptive Tolerance Development by .ALPHA.- and .BETA.-Adrenergic Blockers.

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概要

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• Concomitant treatment with phentolamine, an α-blocker, or with propranolol, a β-blocker, suppressed the development of morphine tolerance in shamoperated (Sham) mice. In adrenalectomized (ADX) mice, daily morphine developed tolerance as well as in the Sham group, and concurrent phentolamine suppressed the development of tolerance, whereas such suppression by propranolol was abolished. Supplemental treatment of ADX mice with dexamethasone did not restore the suppressive effect of propranolol. These results suggest that defferent mechanisms underlie the prevention of tolerance development by α- and β-blockers, and that adrenal cortex does not seem to participate in the suppression by β-blockers.

• 公益社団法人 日本薬理学会の論文

著者

• Takahashi Masakatsu

  Department Of Pharmacoinformatics School Of Pharmaceutical Sciences Nagasaki University

• Kaneto Hiroshi

  Department Of Pharmacology Faculty Of Pharmaceutical Science Nagasaki University

• Okada Tomoko

  Department of Pharmacology, Faculty of Pharmaceutical Sciences, Nagasaki University

• OKADA Tomoko

  Department of Animal Sciences, Teikyo University of Science, 2–2–1 Senju-Sakuragi, Adachi-ku, Tokyo 120–0045, Japan

• Takahashi Masakatsu

  Department of Analytical Research for Pharmacoinformatics, Graduate School of Pharmaceutical Sciences, Nagasaki University

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