Morphine Dependence With or Without Tolerance in Formalin-Treated Mice: Further Evidence for the Dissociation.
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概要
- 論文の詳細を見る
Pain associated-anxiety induced by formalin, which resulted in a significant delay in the development of tolerance to morphine antinociception, failed to prevent the development of physical dependence as evidenced by naloxone challenge. Dependence also developed in mice rendered tolerant to morphine. Thus, the development of morphine dependence was observed in the absence and presence of tolerance to morphine antinociception; Our results further confirm the dissociation of opioid tolerance and dependence in the animal model of experimental pain/anxiety.
- 公益社団法人 日本薬理学会の論文
著者
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Kaneto Hiroshi
Department Of Pharmacology Faculty Of Pharmaceutical Science Nagasaki University
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Rahman A.F.M.
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Nagasaki University
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Takahashi Masakatsu
Department of Analytical Research for Pharmacoinformatics, Graduate School of Pharmaceutical Sciences, Nagasaki University
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