Blockade by Ginseng Extract of the Development of Reverse Tolerance to the Ambulation-Accelerating Effect of Methamphetamine in Mice.

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概要

• 論文の詳細を見る

• Daily repeated administration of methamphetamine (MAP) developed reverse tolerance to its ambulation-accelerating effect. After pretreatment of mice daily with ginseng extract (GE) for 5 days, concomitant injections of MAP and GE suppressed the development of reverse tolerance to the effect of MAP, although GE itself did not affect the spontaneous motor activity of the naive mice. These results provide evidence that GE may be useful for prevention and therapy of the adverse action of MAP.

• 公益社団法人 日本薬理学会の論文

著者

• Tokuyama Shogo

  Department Of Clinical Pharmacy Kobe Gakuin University Faculty Of Pharmaceutical Sciences

• Kim Hack-seang

  Department Of Pharmacy College Of Pharmacy Chungbuk National University

• Takahashi Masakatsu

  Department Of Pharmacoinformatics School Of Pharmaceutical Sciences Nagasaki University

• Kaneto Hiroshi

  Department Of Pharmacology Faculty Of Pharmaceutical Science Nagasaki University

• Oh Ki-Wan

  Department of Pharmacology, College of Pharmacy, Chungbuk National University

• Kim Hack-Seang

  Department of Pharmacology, College of Pharmacy, Chungbuk National University

• Takahashi Masakatsu

  Department of Analytical Research for Pharmacoinformatics, Graduate School of Pharmaceutical Sciences, Nagasaki University

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