Involvement of Adenosine A_2 Receptors in the Changes of Tissue Factor-Dependent Coagulant Activity Induced by Polymorphonuclear Leukocytes in Endothelial Cells
スポンサーリンク
概要
- 論文の詳細を見る
We have already reported that polymorphonuclear leukocytes (PMNs) could increase tissue factor-dependent coagulant activity (TF activity) in endothelial cells mediated by adhesion of PMNs to endothelial cells. In the present study, the role of adenosine receptors in the changes of TF activity and of adhesion between PMNs and endothelial cells was examined. The increases of the TF activity and adhesion were significantly reduced in a concentration-dependent manner by pretreatment of adenosine (0.1 and 1.0 mM); an adenosine A1/A2-receptor agonist, CGS-21680 (5, 10 and 50 μM); and an adenosine A2-receptor agonist, 5-(N-cyclopropyl)-carboxamidoadenosine (CPCA; 1.0, 10 and 100 nM). An adenosine A2-receptor antagonist, 3,7-dimethyl-1-(2-propynyl) xanthine (DMPX; 1.0 and 100 nM), antagonized significantly the reduction of the TF activity and the adhesion induced by adenosine (1.0 mM), while 8-cyclopentyl-1,3-dimethylxanthine (CPDMX; 1.0 and 100 nM), an adenosine A1-receptor antagonist, did not affect it. On the other hand, the TF activity and the adhesion were not changed by N6-cyclohexyladenosine (CHA; 10 and 100 nM) and 2-chloro-N-cyclopentyladenosine (CCPA; 10 and 100 nM), adenosine A1-receptor agonists in the same conditions. These results suggest that the reduction in the TF activity stimulated by PMNs is closely related to the adhesive inhibition between PMNs and endothelial cells through the adenosine A2-receptor-mediated system.
- 社団法人 日本薬理学会の論文
- 2002-04-01
著者
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Yamamoto Toshinori
Drug Safety Research & Development Pfizer Global Research & Development Nagoya Laboratories
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Yamamoto T
Showa Univ. Tokyo Jpn
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Yamamoto Toshinori
Department Of Biochemical Toxicology School Of Pharmaceutical Sciences Showa University
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Tokuyama Shogo
Department of Clinical Pharmacy, Kobe Gakuin University, School of Pharmaceutical Sciences
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Tokuyama Shogo
Department Of Clinical Pharmacy School Of Pharmaceutical Sciences Showa University
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Tokuyama Shogo
Department Of Clinical Pharmacy Kobe Gakuin University Faculty Of Pharmaceutical Sciences
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Yasuda Masako
Laboratory Of Molecular Biology Department Of Synthetic And Biological Chemistry Graduate School Of
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YASUDA Masako
Departments of Clinical Pharmacy, School of Pharmaceutical Sciences, Showa University
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Sasaki T
Kitasato Univ. Aomori Jpn
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WATANABE Tohru
Department of Industrial Chemistry, Tokyo, Metropolitan University
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WATANABE Tomoko
First Department of Internal Medicine, Okayama University Medical School
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SASAKI Tadanori
Department of Clinical Pharmacy, School of Pharmaceutical Sciences, Showa University
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Yamamoto Toshinori
Departments Of Clinical Pharmacy And Pharmacognosy School Of Pharmaceutical Sciences Showa Universit
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Yamamoto T
Department Of Clinical Pharmacy School Of Pharmaceutical Sciences Showa University
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Sasaki Tadanori
Department Of Clinical Pharmacy School Of Pharmaceutical Sciences Showa University
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Yasuda Masako
Department Of Clinical Pharmacy School Of Pharmaceutical Sciences Showa University
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Watanabe Tohru
Department Of Applied Chemistry Graduate School Of Engineering Tokyo Metropolitan University
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Watanabe Tohru
Department Of Clinical Pharmacy School Of Pharmaceutical Sciences Showa University
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Yamamoto Toshinori
Department Of Pharmacology Medical College Of Oita
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