Further evidence for the implication of a .KAPPA.-opioid receptor mechanism in the production of psychological stress-induced analgesia.
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概要
- 論文の詳細を見る
The analgesic effect induced by exposure to psychological stress, using a communication box (psychological stress-induced analgesia, PSY-SIA), was completely antagonized by 10 min pretreatment with 0.5, 1 and 2 mg/kg of nor-binaltorphimine and with 0.5 and 1 mg/kg of Mr2266, selective κ-opioid receptor antagonists, in the tail pinch method. Neither footshock (FS)- nor forced swimming (SW)-SIA was affected by these antagonists. The selective δ-opioid receptor antagonist naltrindole, at doses up to 20 mg/kg, had no appreciable effect on PSY-SIA. Daily morphine treatment, 10 mg/kg, s.c., resulted in tolerance to the analgesic effect, and concurrent exposure to PSY-stress suppressed the development of morphine tolerance. The substitution of treatment with U-50, 488H for PSY-stress still resulted in analgesia on the initial day; and likewise, the suppression by U-50, 488H of the development of morphine tolerance was replicated by PSY-stress. Pretreatment with nor-binaltorphimine antagonized the suppressive effect of PSY-stress on the development of morphine tolerance without affecting the analgesic effect of morphine per se. These results provide further evidence that PSY-SIA involves the mediation by κ-opioid receptor mechanisms.
- 公益社団法人 日本薬理学会の論文
著者
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Tokuyama Shogo
Department Of Clinical Pharmacy Kobe Gakuin University Faculty Of Pharmaceutical Sciences
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Takahashi Masakatsu
Department Of Pharmacoinformatics School Of Pharmaceutical Sciences Nagasaki University
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Kaneto Hiroshi
Department Of Pharmacology Faculty Of Pharmaceutical Science Nagasaki University
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SENDA Toshihiko
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Nagasaki University
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