Effect of 4-(4-Chlorobenzyl)pyridine on Rat Hepatic Microsomal Cytochrome P450 and Drug-Metabolizing Enzymes in Vivo and in Vitro
スポンサーリンク
概要
- 論文の詳細を見る
The effects of 4-(4-chlorobenzyl)pyridine(4-CBP) on rat hepatic microsomal cytochrome P450(P450) and its molecular species(CYP2B1, 2E1, 3A2, 2C11, and 2C12), and on drug-metabolizing enzyme activities were examined in vivo and in vitro. Treatment of rats with 4-CBP resulted in the induction of P450 and drug-metabolizing enzymes in dose-dependent manner, but it was markedly inhibitory at higher does levels. Immunoblot analyses revealed that 4-CBP induces both CYP2B1 and 2E1 ; however, both were decreased by increasing the dose of 4-CBP. The in vitro inhibitory experiment revealed that 4-CBP strongly inhibited benzphetamine N-demethylase activity, but not dimethylnitrosamine N-demethylase activity. The present findings provide information on the induction and inhibition effects of chlorinated benzylpyridine on hepatic microsomal P450s and drug-metabolizing enzymes in vivo and in vitro.
- 公益社団法人日本薬学会の論文
- 2001-05-01
著者
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Yamamoto T
Showa Univ. Tokyo Jpn
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Yamamoto Toshinori
Department Of Biochemical Toxicology School Of Pharmaceutical Sciences Showa University
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Tokuyama Shogo
Department of Clinical Pharmacy, Kobe Gakuin University, School of Pharmaceutical Sciences
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Tokuyama Shogo
Department Of Clinical Pharmacy School Of Pharmaceutical Sciences Showa University
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Tokuyama Shogo
Department Of Clinical Pharmacy Kobe Gakuin University Faculty Of Pharmaceutical Sciences
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Yoshida Tomoko
Department Of Nuclear Engineering Nagoya University
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Yoshida Takemi
Dept.biochem.toxicol. Showa Univ.
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Yoshida T
Department Of Biochemical Toxicology School Of Pharmaceutical Science Showa University
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Yoshida Takemi
Department Of Biochemical Toxicology School Of Pharmaceutical Sciences Showa University
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Yoshida T
Department Of Biochemical Toxicology School Of Pharmaceutical Sciences Showa University
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Sasaki T
Kitasato Univ. Aomori Jpn
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Yoshida Teiji
Department Of Physics Faculty Of Science Tohoku University
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KOBAYASHI Yasuna
Department of Clinical Pharmacy, Showa University School of Pharmaceutical Sciences
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SASAKI Tadanori
Department of Clinical Pharmacy, School of Pharmaceutical Sciences, Showa University
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OHSHIRO Naomi
Department of Physiology and Biophysics, University of Texas Medical Branch at Galveston
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TOBE Takashi
Med.Inform., Sch.of Pharm.Sci., Showa Univ.
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Yoshida Takemi
Biochem.Toxicol.
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TOBE Takashi
Medicinal Information, School of Pharmaceutical Sciences, School of Pharmaceutical Sciences, Showa U
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Yoshida Takahiko
Department Of Environmental Health Division Of Community And Environmental Health Tokai University S
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Yamamoto T
Department Of Clinical Pharmacy School Of Pharmaceutical Sciences Showa University
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Tobe Takashi
Med.inform. Sch.of Pharm.sci. Showa Univ.
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Ohshiro Naomi
Department Of Physiology And Biophysics University Of Texas Medical Branch At Galveston
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Yoshida Takemi
School Of Pharmaceutical Sciences Showa University
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Kobayashi Y
Faculty Of Pharmaceutical Sciences Teikyo University Sagamiko
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Kobayashi Y
Department Of Clinical Pharmacy School Of Pharmaceutical Sciences Showa University
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Sasaki Tadanori
Department Of Clinical Pharmacy School Of Pharmaceutical Sciences Showa University
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Kobayashi Yasuna
Department Of Clinical Pharmacy Showa University School Of Pharmaceutical Sciences
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Yoshida Takemi
Pfizer Japan Inc. Drug Safety R&d Pfizer Global R&d
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Yoshida Tomoko
Department of Biochemical Toxicology, School of Pharmacy Showa University
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