Mechanism of Salivary Secretion Enhancement by Byakkokaninjinto(Pharmacology)
スポンサーリンク
概要
- 論文の詳細を見る
Byakkokaninjinto (BN) is a Kampo preparation used for the treatment of xerostomia induced by drug, ageing, Sjogren syndrome, etc. The mechanism for BN to induce salivary secretion has not been made clear. In thisstudy, various rat thirst models were prepared using muscarinic receptor blockers, such as 4-diphenylacetoxy-N-methylpiperidine (4-DAMP) and atropine, or adrenoceptor blockers, such as phentolamine and propranolol, in order to investigate the efficiency of BN. When BN was orally administered to the rats in the dose range of 100 to 300 mg/kg, the salivary secretion increased in a dose-dependent manner. The suppression of salivary secretion induced by phentolamine, atropine, and 4-DAMP was recovered by the additional treatment of BN. Interestingly, BN treatment increased the expression of aquaporin 5 in rats, which is known to regulate salivary secretion from the submandibular gland. These results suggested that BN increased the expression of aquaporin 5 through activation of muscarinic M3 receptor and enhanced salivary secretion.
- 公益社団法人日本薬学会の論文
- 2008-03-01
著者
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Yamamoto Toshinori
Department Of Biochemical Toxicology School Of Pharmaceutical Sciences Showa University
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YASUDA Masako
Departments of Clinical Pharmacy, School of Pharmaceutical Sciences, Showa University
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Hashida Kei
Department of Internal Medicine, Ehime National Hospital
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Yamamoto Toshinori
Department Of Clinical Pharmacy School Of Pharmaceutical Sciences Showa University
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Hashida Kei
Department Of Clinical Pharmacy School Of Pharmaceutical Sciences Showa University
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Yasuda Masako
Department Of Clinical Pharmacy School Of Pharmaceutical Sciences Showa University
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YANAGI Yuichiro
Showa University Yokohama Northern Hospital
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KADOKURA Yoshiyuki
Showa University Yokohama Northern Hospital
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SUZAKI Harumi
Department of Otolaryngology, Showa University
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Suzaki Harumi
Department Of Otolaryngology Showa University
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Suzaki Harumi
Department Of Otolaryngology School Of Medicine Showa University
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