Stimulation of In Vitro Angiogenesis by Tetrahydrobiopterin in Bovine Aortic Endothelial Cells
スポンサーリンク
概要
- 論文の詳細を見る
This study examined whether tetrahydrobiopterin (BH4) stimulates angiogenesis by measuring the formation of tube-like structures in vascular endothelial cells. Bovine aortic endothelial cells that were cultured between two layers of collagen type I gel formed tube-like networks. Addition of BH4 or sepiapterin, a precursor of BH4 synthesis, stimulated the formation of tube-like structures. The sepiapterin-stimulated tube formation was completely inhibited by co-treatment with N-acetylserotonin, an inhibitor of sepiapterin reductase. These findings show that BH4 stimulates in vitro angiogenesis in vascular endothelial cells.
- 社団法人 日本薬理学会の論文
- 1999-06-01
著者
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ISHII Masakazu
Department of Cardiology, Nagoya University Graduate School of Medicine
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Yamamoto Toshinori
昭和大学 医学部第2外科
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Yamamoto Toshinori
Department Of Biochemical Toxicology School Of Pharmaceutical Sciences Showa University
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Mori Y
Center For Integrative Bioscience Okazaki National Research Institutes
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Ishii Masakazu
Department Of Cardiology Nagoya University Graduate School Of Medicine
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Ishii Masakazu
Department Of Pathophysiology School Of Pharmacy Showa University
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Ishii Masakazu
Center For Integrative Bioscience Okazaki National Research Institutes
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Yasuda Masako
Laboratory Of Molecular Biology Department Of Synthetic And Biological Chemistry Graduate School Of
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SHIMIZU Shunichi
Department of Pathophysiology, School of Pharmaceutical Sciences, Showa University
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KIUCHI Yuji
Department of Pathophysiology, School of Pharmaceutical Sciences, Showa University
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YASUDA Masako
Departments of Clinical Pharmacy, School of Pharmaceutical Sciences, Showa University
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NAGAI Tsutomu
Departments of Clinical Pharmacy, School of Pharmaceutical Sciences, Showa University
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Yamamoto Toshinori
Clinical Pharmacy School Of Pharmaceutical Sciences Showa University
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Yamamoto T
Okayama Univ. Medical School Okayama Jpn
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Kiuchi Yuji
Center Of Pharmaceutical Education School Of Pharmacy Showa Univ.
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Kiuchi Y
Department Of Electronic Engineering Faculty Of Technology Tokyo University Of Agriculture And Techn
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Kiuchi Yuji
Department Of Electronic Engineering Faculty Of Technology Tokyo University Of Agriculture And Techn
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Nagai Tsutomu
Departments Of Clinical Pharmacy School Of Pharmaceutical Sciences Showa University
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Yasuda Masako
Department Of Clinical Pharmacy School Of Pharmaceutical Sciences Showa University
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Yamamoto Toshinori
Department Of Clinical Pharmacy Showa University School Of Pharmaceutical Sciences
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Masuda Yutaka
Department Of Anesthesiology School Of Medicine
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Shimizu Shunichi
Dep. Of Pathophysiology School Of Pharmacy Showa Univ.
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