Current Perspective : Dissecting Receptor-Mediated Ca^<2+> Influx Pathways : TRP Channels and Their Native Counterparts

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概要

• 論文の詳細を見る

• Cellular stimulation from the surrounding extracellular environment via receptors and other pathways evoke activation of Ca2+-permeable cation channels that form essential signaling pathways in controlling biological responses. An important clue to understand the molecular mechanisms underlying these cation channels (tentatively termed as receptor-mediated cation channels (RMCC)) was first provided through molecular studies of the transient receptor potential (trp) protein (TRP), which controls light-induced depolarization in Drosophila photoreceptor cells. Use of the genetic information and recombinant expression technique lead to the discovery of numerous mammalian TRP homologues revealing novel RMCCs. In this review, we focus on the dramatic progress in the molecular investigation of RMCC in mammalian systems. The recent findings should provide powerful tools for the development of novel pharmaceutical targets.

• 社団法人 日本薬理学会の論文
• 2001-12-01

著者

• Inoue Ryuji

  Department of Physiology, School of Medicine, Fukuoka University

• Hara Yuji

  Department Of Pharmacology Graduate School Of Pharmaceutical Sciences Kyoto University

• Hara Yuji

  Center For Integrative Bioscience Okazaki National Research Institutes

• Mori Y

  Center For Integrative Bioscience Okazaki National Research Institutes

• Ishii Masakazu

  Department Of Pathophysiology School Of Pharmacy Showa University

• Ishii Masakazu

  Center For Integrative Bioscience Okazaki National Research Institutes

• Yasuda Masako

  Laboratory Of Molecular Biology Department Of Synthetic And Biological Chemistry Graduate School Of

• Honda Y

  Department Of Ophthalmology And Visual Sciences Graduate School Of Medicine Kyoto University

• Inoue Ryuji

  Department Of Physiology School Of Medicine Fukuoka University

• Inoue Ryuji

  Department Of Pharmacology Faculty Of Medicine Kyushu University

• IMOTO Keiji

  Department of Information Physiology, National Institute for Physiological Sciences

• Imoto Keiji

  Department Of Information Physiology National Institute For Physiological Sciences

• Imoto K

  Department Of Information Physiology National Institute For Physiological Sciences Okazaki National

• MORI Yasuo

  Center for Integrative Bioscience, Okazaki National Research Institutes

• Masuda Yutaka

  Department Of Anesthesiology School Of Medicine

• Inoue Ryuji

  Special Patient Oral Care Unit Kyushu University Hospital

• Mori Yasuo

  Center for Integrative Bioscience, National Institute for Physiological Sciences

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