Retinal Neurotoxicity of Nitric Oxide Donors With Different Half-Life of Nitric Oxide Release: Involvement of N-Methyl-D-aspartate Receptor
スポンサーリンク
概要
- 論文の詳細を見る
We compared the degree of neurotoxic outcome in the retina exposed to three nitric oxide (NO) donors with different half-life of NO release. Intravitreal injection of NO donors resulted in a significant decrease in cell density in the ganglion cell layer and thinning of the inner plexiform layer in a half-life time-dependent manner. Concurrent injection of an NO-trapping reagent with an NO donor abolished NO donor-induced retinal damage. (+)-MK-801 also prevented NO-induced retinal damage, indicating that N-methyl-<sc>D</sc>-aspartate receptors are partly involved in NO-induced neurodegeneration. These results may be relevant to a pathogenic role of NO – glutamate receptor in several ophthalmic disorders.
- 社団法人 日本薬理学会の論文
- 2003-08-01
著者
-
Katsuki Hiroshi
Department of Chemico-Pharmacological Sciences, Graduate School of Pharmaceutical Sciences, Kumamoto
-
Kume Toshiaki
京都大学 薬学研究科生体機能解析学
-
Kume Toshiaki
京都大学 薬学研究科薬品作用解析学分野
-
Kume Toshiaki
京都大学 薬学研究科薬品作用解析学
-
Kume Toshiaki
同志社女子大学 医療薬学科薬理学
-
Kume Toshiaki
Department Of Pharmaceutical Science Kyoto University Graduate School Of Pharmacology
-
Takada-takatori Yuki
京都大学 薬学研究科薬品作用解析学
-
Akaike A
Department Of Pharmacology Graduate School Of Pharmaceutical Sciences Kyoto University
-
Akaike Akinori
京都大学 薬学研究科生体機能解析学
-
Akaike Akinori
京都薬科大学 病態生理
-
Akaike Akinori
Department Of Pharmacology Graduate School Of Pharmaceutical Sciences Kyoto University
-
Kume Toshiaki
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Kyoto University
-
Hara Yuji
Department Of Pharmacology Graduate School Of Pharmaceutical Sciences Kyoto University
-
Hara Yuji
Center For Integrative Bioscience Okazaki National Research Institutes
-
HONDA Yoshihito
Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine
-
Honda Y
Department Of Ophthalmology And Visual Sciences Graduate School Of Medicine Kyoto University
-
Honda Yoshihito
Department Of Ophthalmology And Visual Science Graduate School Of Medicine Kyoto University
-
Akaike Akinori
Department Of Pharmaceutical Science Kyoto University Graduate School Of Pharmacology
-
KASHII Satoshi
Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine
-
TOCHIKAWA Yoshinaga
Institute of Research and Development, Fujimoto Pharmaceutical Corporation
-
TAKAHATA Kazue
Institute of Research and Development, Fujimoto Pharmaceutical Corporation
-
ITO Ken
Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University
-
MURAOKA Shizuko
Institute of Research and Development, Fujimoto Pharmaceutical Corporation
-
YONEDA Fumio
Institute of Research and Development, Fujimoto Pharmaceutical Corporation
-
TAKAHATA Kazue
Research Institute, Fujimoto Pharmaceutical Corporation
-
YONEDA Fumio
Research Institute, Fujimoto Pharmaceutical Corporation
-
Yoneda Fumio
Institute Of Research And Development Fujimoto Pharmaceutical Corporation
-
Takahata Kazue
Institute Of Research And Development Fujimoto Pharmaceutical Corporation
-
Kashii S
Department Of Ophthalmology And Visual Sciences Graduate School Of Medicine Kyoto University
-
Kashii Satoshi
Department Of Ophthalmology And Visual Sciences Kyoto University Graduate School Of Medicine
-
Kashii Satoshi
Department Of Ophthalmology And Visual Sciences Graduate School Of Medicine Kyoto University
-
Tochikawa Yoshinaga
Institute Of Research And Development Fujimoto Pharmaceutical Corporation
-
Katsuki Hiroshi
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences The University Of Tokyo
-
Takada-takatori Yuki
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Doshisha Women's College
-
Akaike Akinori
Dep. Of Pharmacology Graduate School Of Pharmaceutical Sciences Kyoto Univ. Jpn
-
Katsuki Hiroshi
Department Of Chemico-pharmacological Sciences Graduate School Of Pharmaceutical Sciences Kumamoto U
-
Muraoka Shizuko
Institute Of Research And Development Fujimoto Pharmaceutical Corporation
-
Ito Ken
Department Of Functional Diagnostic Science Osaka University Graduate School Of Medicine
-
Ito Ken
Department Of Applied Physics Osaka City University
-
Kume T
Department Of Pharmacology Graduate School Of Pharmaceutical Sciences Kyoto University
-
Akaike Akinori
Department of Neuropharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University
関連論文
- Glycyrrhizin Attenuates Mucus Production by Inhibition of MUC5AC mRNA Expression In Vivo and In Vitro
- Neuronal Nitric Oxide Synthase Is Crucial for Ganglion Cell Death in Rat Retinal Explant Cultures
- Mechanisms of Chronic Nicotine Treatment–Induced Enhancement of the Sensitivity of Cortical Neurons to the Neuroprotective Effect of Donepezil in Cortical Neurons
- Excitotoxicity-Associated p53 Expression in Adult Rat Retina Is Mediated by Calpain Activity but Not by Cl^- Influx
- Roles of Nicotinic Receptors in Acetylcholinesterase Inhibitor-Induced Neuroprotection and Nicotinic Receptor Up-Regulation(Functional Changes Induced by Long-Term Stimulation of Nicotinic Acetylcholine Receptors)
- Serofendic Acid Promotes Stellation Induced by cAMP and cGMP Analogs in Cultured Cortical Astrocytes
- Transient Intraocular Pressure Elevation after Trabeculotomy and its Occurrence with Phacoemulsification and Intraocular Lens Implantation
- Multicenter Genetic Study of Retinitis Pigmentosa in Japan : I. Genetic Heterogeneity in Typical Retinitis Pigmentosa
- Multicenter Genetic Study of Retinitis Pigmentosa in Japan : II. Prevalence of Autosomal Recessive Retinitis Pigmentosa
- Glycyrrhizin Inhibits Interleukin-8 Production and Nuclear Factor-κB Activity in Lung Epithelial Cells, but Not Through Glucocorticoid Receptors
- PJ-104 Serofendic Acid, a Novel Substance Extracted from Fetal Calf Serum, Protects against Oxidative Stress in Neonatal Rat Cardiac Myocytes(Myocardial ischemia-reperfusion, basic/clinical-5 (IHD) PJ18,Poster Session (Japanese),The 70th Anniversary Annua
- Pars Plana Vitrectomy for Epiretinal Membrane Associated with Sarcoidosis
- Reproducibility of Scanning Laser Doppler Flowmetry in the Rat Retina and Optic Nervehead
- Pharmacological Characteristics of Rotational Behavior in Hemiparkinsonian Rats Transplanted With Mouse Embryonic Stem Cell-Derived Neurons
- Serofendic acid protects from iodinated contrast medium and high glucose probably against superoxide production in LLC-PK1 cells
- Dual effect of serotonin on formalin-induced nociception in the rat spinal cord
- The Parkinsonian Models : Invertebrates to Mammals
- Effects of Nicotinic Receptor Agonists on Beta-Amyloid Beta-Sheet Formation
- Foreword(Functional Changes Induced by Long-Term Stimulation of Nicotinic Acetylcholine Receptors)
- Co-culture With the Striatum Attenuates N-Methyl-D-aspartate Cytotoxicity in Dopaminergic Neurons of Rat Mesencephalic Slice Cultures
- Bifemelane Protects Cultured Cortical Neurons Against N-Methyl-D-aspartate Receptor-Mediated Glutamate Cytotoxicity
- Protective Effect of MKC-231, a Novel High Affinity Choline Uptake Enhancer, on Glutamate Cytotoxicity in Cultured Cortical Neurons
- Suppressive effect of zinc ion on iNOS expression induced by interferon-γ or tumor necrosis factor-α in murine keratinocytes
- Involvement of apoptosis and cholinergic dysfunction in Alzheimer's disease
- EFFECTS OF OPIOID PEPTIDES ON NEURONAL ACTIVITIES OF THE CNS : STUDIES USING MICROELECTROPHORETIC METHOD
- Human V5 demonstrated by magnetoencephalography using random dot kinematograms of different coherence levels
- Neuroprotective action of donepezil mediated by neuronal nicotinic receptors
- A Critical Role of TRPM2 in Neuronal Cell Death by Hydrogen Peroxide
- Donepezil Potentiates Nerve Growth Factor-Induced Neurite Outgrowth in PC12 Cells
- Contribution of endogenous glycine site NMDA agonists to excitotoxic retinal damage in vivo
- Mechanisms of oxygen glucose deprivation-induced glutamate release from cerebrocortical slice cultures
- Endogenous Factors Regulating Neuronal Death Induced by Radical Stress(Mitochondria and Neuroprotection)
- Retinal Neurotoxicity of Nitric Oxide Donors With Different Half-Life of Nitric Oxide Release: Involvement of N-Methyl-D-aspartate Receptor
- Ether Extract of Fetal Cakf Serum Protects Cultured Rat Cortical Neurons against Glutamate Cytotoxicity
- Basic and Clinical Aspects of Non-neuronal Acetylcholine : Expression of an Independent, Non-neuronal Cholinergic System in Lymphocytes and Its Clinical Significance in Immunotherapy
- Overexpression of the Wilms' tumor gene WT1 in primary astrocytic tumors
- Effects of R-(-)-BPAP on the Expressions of Neurotrophins and Their Receptors in Mesencephalic Slices(Pharmacology)
- Wilms' tumor gene WT1 17AA(-)/KTS(-) isoform induces morphological changes and promotes cell migration and invasion in vitro
- Role of Vitronectin Receptor-Type Integrins and Osteopontin in Ischemia-Induced Retinal Neovascularization
- Electron Wave Transfer in Coupled Quantum Wires and Its Control by Externally Applied Electric Field
- Orbital Pseudotumor as an Initial Manifestation of Multicentric Castleman's Disease
- DISTRIBUTION OF FODRIN AND α-ACTININ IN THE RAT RETINAL PIGMENT EPITHELIUM IN VIVO
- CYTOCHEMICAL DEMONSTRATION OF LECTIN BINDING SITES IN ROD PHOTORECEPTOR CELLS AND INTERPHOTORECEPTOR MATRIX OF RAT RETINAS BY LABELING FROZEN THIN-SECTIONS WITH VARIOUS LECTINS
- Furosemide : Sensitive Calcium Rise Induced by GABA_A : Receptor Stimulation in Cultures of Embryonic Rat Striatal Neurons
- Na+/Ca2+ Exchanger Inhibitors Inhibit Neurite Outgrowth in PC12 Cells
- Long-Term Outcome After Radiation Therapy for Subfoveal Choroidal Neovascularization Associated with Age-Related Macular Degeneration
- Temperature-Dependent Percolation in the Ordered Phase : Square Lattice-Gas Model
- Generation of knock-in mice carrying third cones with spectral sensitivity different from S and L cones
- Temperature-Dependent Percolation in the Square Lattice
- Glutathione Biosynthesis via Activation of the Nuclear Factor E2–Related Factor 2 (Nrf2) – Antioxidant-Response Element (ARE) Pathway Is Essential for Neuroprotective Effects of Sulforaphane and 6-(Methylsulfinyl) Hexyl Isothiocyanate
- Involvement of TRPM7 in Cell Growth as a Spontaneously Activated Ca^ Entry Pathway in Human Retinoblastoma Cells
- Current Perspective : Dissecting Receptor-Mediated Ca^ Influx Pathways : TRP Channels and Their Native Counterparts
- Receptor-Mediated Modulation of Voltage-Dependent Ca^ Channels via Heterotrimeric G-proteins in Neurons
- Inhibitory Effects of Bifemelane on Brain Ca^ Channel Subtypes Expressed in Xenopus Oocytes
- Inhibition by [Arg8]-Vasopressin of Long Term Potentiation in Guinea Pig Hippocampal Slice
- Involvement of M_2 receptor in an enhancement of long-term potentiation by carbachol in Schaffer collateral-CA1 synapses of hippocampal slices
- SURGICAL RESULTS AND COMPLICATIONS OF TRABECULECTOMY WITH INTRAOPERATIVE APPLICATION OF MITOMYCIN C
- Cause and Prognosis of Neurologically Isolated Third, Fourth, or Sixth Cranial Nerve Dysfunction in Cases of Oculomotor Palsy
- Analysis of Cyclosporin A-Induced Reversible Cortical Blindness by Diffusion-Weighted Magnetic Resonance Imaging Techniques
- Magnetoconductance in Open Stadium Billiard : Quantum Analogue of Transition from Chaos to Tori
- Electrical Activity of the Human Retina in Vitro(SYMPOSIUM ON ELECTRORETINOGRAPHY)
- Disseminated Mycobacterium avium Complex Infection in a Patient with Autoantibody to Interferon-γ
- Exploring Neuroprotective Drug Therapies for Intracerebral Hemorrhage
- Mechanisms of Chronic Nicotine Treatment-Induced Enhancement of the Sensitivity of Cortical Neurons to the Neuroprotective Effect of Donepezil in Cortical Neurons
- Glycyrrhizin Attenuates Mucus Production by Inhibition of MUC5AC mRNA Expression In Vivo and In Vitro
- Glycyrrhizin Inhibits IL-8 Production and NF-κB Activity in Lung Epithelial Cells, But Not Through Glucocorticoid Receptors
- Prognostic Factors for Hypotensive Effects of Isopropyl Unoprostone in Eyes With Primary Open-Angle Glaucoma
- IMMUNOCYTOCHEMICAL STUDY OF FODRIN IN THE RAT RETINAL PIGMENT EPITHELIUM
- Effects of vitamin B_6 and its related compounds on survival of cultured brain neurons
- The Effects of Thiamine and Oxythiamine on the Survival of Cultured Brain Neurons
- YM-14673,a New Thyrotropin-Releasing Hormone Analog, Augments Long-Term Potentiation in the Mossy Fiber-CA3 System of Guinea Pig Hippocampal Slices
- Indeloxazine Augments Long-Term Potentiation in the Mossy Fiber-CA3 System of Guinea Pig Hippocampal Slices
- Palladium-Catalyzed Ternary Coupling Reaction of Aryl Halide, Phenyltributyltin, and Norbornadiene. Catalyst Tailoring
- 3-Hydroxykynurenine Toxicity on the Rat Striatum In Vivo
- BRADYKININ-INDUCED FLEXOR REFLEX OF RABBIT HINDLIMB FOR COMPARING ANALGESICS
- EFFECTS OF INDOMETHACIN AND THE OTHER ANTI-INFLAMMATORY AGENTS ON ACTIVATION OF DORSAL HORN CELL IN THE SPINAL CORD INDUCED BY INTRA-ARTERIAL INJECTION OF BRADYKININ
- Effects of coculture with the septum on the expression of long-term potentiation in organotypic hippocampal slice cultures
- Developmental expression of β-catenin in mouse retina
- Neuronal Nitric Oxide Synthase Is Crucial for Ganglion Cell Death in Rat Retinal Explant Cultures
- Sedative effects of vapor inhalation of the essential oil of Microtoena patchoulii and its related compounds
- Na^+/Ca^ Exchanger Inhibitors Inhibit Neurite Outgrowth in PC12 Cells
- Glutathione Biosynthesis via Activation of the Nuclear Factor E2-Related Factor 2 (Nrf2)-Antioxidant-Response Element (ARE) Pathway Is Essential for Neuroprotective Effects of Sulforaphane and 6-(Methylsulfinyl) Hexyl Isothiocyanate
- Exploring Neuroprotective Drug Therapies for Intracerebral Hemorrhage
- High circulating levels of interleukin-18 binding protein indicate the severity of glomerular involvement in systemic lupus erythematosus
- Tamibarotene: A Candidate Retinoid Drug for Alzheimer’s Disease
- Pharmacological Characteristics of Rotational Behavior in Hemiparkinsonian Rats Transplanted With Mouse Embryonic Stem Cell-Derived Neurons
- Glucocorticoids Decrease Astrocyte Numbers by Reducing Glucocorticoid Receptor Expression In Vitro and In Vivo
- In Vivo Brain Oxidative Stress Model Induced by Microinjection of Sodium Nitroprusside in Mice
- Glucocorticoids Decrease Astrocyte Numbers by Reducing Glucocorticoid Receptor Expression In Vitro and In Vivo
- In Vivo Brain Oxidative Stress Model Induced by Microinjection of Sodium Nitroprusside in Mice
- Protective Effect of Luteolin on an Oxidative-Stress Model Induced by Microinjection of Sodium Nitroprusside in Mice
- Effects of ethanol applied by electrosmosis on neurons in the lateral and medial vestibular nuclei.
- Ethanol inhibits vestibular and caloric nystagmus without affecting optokinetic nystagmus in rabbits.
- Blockade of Retinal NMDA Receptors by Sodium Nitroprusside Is Probably Due to Nitric Oxide Formation.
- Characterization of .BETA.-Adrenoceptors in Pig Basilar Artery from Functional and Radioligand Binding Studies.
- Effects of Protein Kinase C on the Muscarinic Excitation of Rat Adrenal Chromaffin Cells.
- Protective Effect of Luteolin on an Oxidative-Stress Model Induced by Microinjection of Sodium Nitroprusside in Mice