Exploring Neuroprotective Drug Therapies for Intracerebral Hemorrhage
スポンサーリンク
概要
- 論文の詳細を見る
Intracerebral hemorrhage (ICH) is a devastating neurological disorder with high mortality and poor prognosis, for which virtually no effective drug therapies are available at present. Experimental animal models, based on intrastriatal injection of collagenase or autologous blood, have enabled great advances in elucidation of cellular/molecular events contributing to brain pathogenesis associated with ICH. Many lines of evidence indicate that blood constituents, including hemoglobin-derived products as well as proteases such as thrombin, play important roles in the pathogenic events. Inflammatory reactions involving neutrophils, activated microglia, and production of proinflammatory cytokines also constitute a critical aspect of pathology leading to neurodegeneration and tissue damage. Efforts are continuing to find drugs that potentially alleviate pathological and neurological outcomes of ICH. Various drugs that possess antioxidative, anti-inflammatory or neurotrophic/neuroprotective properties have been demonstrated to produce therapeutic effects on ICH animal models. Drugs already in clinical use such as minocycline, statins, and several nuclear receptor ligands are among the list of effective drugs, but whether they also show therapeutic efficacy in human ICH patients remains unproven. Here, current knowledge of ICH pathogenesis and problems arising with respect to exploration of new drug candidates are discussed.
著者
関連論文
- Glycyrrhizin Attenuates Mucus Production by Inhibition of MUC5AC mRNA Expression In Vivo and In Vitro
- Neuronal Nitric Oxide Synthase Is Crucial for Ganglion Cell Death in Rat Retinal Explant Cultures
- Excitotoxicity-Associated p53 Expression in Adult Rat Retina Is Mediated by Calpain Activity but Not by Cl^- Influx
- Serofendic Acid Promotes Stellation Induced by cAMP and cGMP Analogs in Cultured Cortical Astrocytes
- Glycyrrhizin Inhibits Interleukin-8 Production and Nuclear Factor-κB Activity in Lung Epithelial Cells, but Not Through Glucocorticoid Receptors
- Neuroprotective action of donepezil mediated by neuronal nicotinic receptors
- A Critical Role of TRPM2 in Neuronal Cell Death by Hydrogen Peroxide
- Donepezil Potentiates Nerve Growth Factor-Induced Neurite Outgrowth in PC12 Cells
- Contribution of endogenous glycine site NMDA agonists to excitotoxic retinal damage in vivo
- Mechanisms of oxygen glucose deprivation-induced glutamate release from cerebrocortical slice cultures
- Endogenous Factors Regulating Neuronal Death Induced by Radical Stress(Mitochondria and Neuroprotection)
- Retinal Neurotoxicity of Nitric Oxide Donors With Different Half-Life of Nitric Oxide Release: Involvement of N-Methyl-D-aspartate Receptor
- Effects of R-(-)-BPAP on the Expressions of Neurotrophins and Their Receptors in Mesencephalic Slices(Pharmacology)
- Furosemide : Sensitive Calcium Rise Induced by GABA_A : Receptor Stimulation in Cultures of Embryonic Rat Striatal Neurons
- Exploring Neuroprotective Drug Therapies for Intracerebral Hemorrhage
- Glycyrrhizin Attenuates Mucus Production by Inhibition of MUC5AC mRNA Expression In Vivo and In Vitro
- Glycyrrhizin Inhibits IL-8 Production and NF-κB Activity in Lung Epithelial Cells, But Not Through Glucocorticoid Receptors
- Effects of vitamin B_6 and its related compounds on survival of cultured brain neurons
- The Effects of Thiamine and Oxythiamine on the Survival of Cultured Brain Neurons
- YM-14673,a New Thyrotropin-Releasing Hormone Analog, Augments Long-Term Potentiation in the Mossy Fiber-CA3 System of Guinea Pig Hippocampal Slices
- Indeloxazine Augments Long-Term Potentiation in the Mossy Fiber-CA3 System of Guinea Pig Hippocampal Slices
- 3-Hydroxykynurenine Toxicity on the Rat Striatum In Vivo
- Effects of coculture with the septum on the expression of long-term potentiation in organotypic hippocampal slice cultures
- Neuronal Nitric Oxide Synthase Is Crucial for Ganglion Cell Death in Rat Retinal Explant Cultures
- Exploring Neuroprotective Drug Therapies for Intracerebral Hemorrhage
- Tamibarotene: A Candidate Retinoid Drug for Alzheimer’s Disease