The Effects of Thiamine and Oxythiamine on the Survival of Cultured Brain Neurons
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概要
- 論文の詳細を見る
The effects of treatment with thiamine (Vitamin B<SUB>1</SUB>) alone or together with its antagonist oxythiamine on the survival of brain neurons in primary culture were investigated. Treatment with thiamine significantly promoted the survival of hippocampal neurons in high cell density culture, but had no effects on the neuronal survival in low cell density culture. In addition, the survival-promoting activity exerted by thiamine was remarkably decreased by the co-application of oxythiamine, although oxythiamine used alone revealed neither a trophic nor toxic effect on the neurons of examined brain regions. The neurotrophic function of thiamine may be due to its coenzymatic role in a biochemical reaction and/or its specific function on neurotransmission and nerve conduction.
- 社団法人 日本薬理学会の論文
- 1995-07-01
著者
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SAITO HIROSHI
Department of Neurology, Tohoku University School of Medicine
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Geng M‐y
Univ. Tokyo Tokyo Jpn
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Saito H
Department Of Biochemistry Faculty Of Pharmaceutical Sciences Fukuoka University
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Geng Mei-yu
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences The University Of Tokyo
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Katsuki H
Univ. Tokyo Tokyo Jpn
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Katsuki Hiroshi
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences The University Of Tokyo
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Saito Hiroshi
Department Of Cardiovascular Medicine Osaka University Graduate School Of Medicine
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Saito Hiroshi
Department of Applied Chemistry, Graduate School of Engineering, Tohoku University
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