Involvement of a Peripheral Mechanism in the Emesis Induced by Cardiac Glycosides in Suncus murinus
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概要
- 論文の詳細を見る
The ability of three cardiac glycosides, ouabain, digitonin and digitoxin, to induce emesis and their mechanism(s) of action were investigated n Suncus murinus. The intraperitoneal injection of ouabain but not digitonin nor digitoxin caused vomiting in a dose-dependent manner. However, the administration of ouabain into the cerebroventricle did not cause emesis. Ouabain-induced emesis was partly prevented by surgical abdominal vagotomy. Pretreatment with tropisetron, a selective 5-HT_3 (5-hydroxytriptamine) receptor antagonist, did not affect the emetic response evoked by ouabain. These results suggest that ouabain exerts emetic effects via peripheral mechanism(s), but 5-HT_3 receptors are not involved in the pathway.
- 公益社団法人日本薬学会の論文
- 1997-05-15
著者
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松本 直章
東京大学大学院農学生命科学研究科獣医臨床病理学教室
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SAITO HIROSHI
Department of Neurology, Tohoku University School of Medicine
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MATSUKI Norio
Department of Chemical Pharmacology,Faculty of Pharmaceutical Sciences
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Matsuki Norio
Lab. Of Chemical Pharmacology Graduate School Of Pharmaceutical Sciences The Univ. Of Tokyo Jpn
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Matsuki N
Univ. Tokyo Tokyo Jpn
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斉藤 博満
協和発酵・東京研
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Matsuki Norio
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences
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Matsuki Norio
Graduate School Of Pharmaceutical Sciences The University Of Tokyo
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Matsuki Norio
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Science The University Of Tokyo
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Saito H
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences The University Of Tokyo
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KAKIMOTO Shuichiro
Department of Chemical Pharmacology, Faculty of Pharmaceutical Science, The University of Tokyo
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Kakimoto Shuichiro
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Science The University Of Tokyo
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Saito Hideyuki
Department Of Pharmacology College Of Pharmacy Nihon University
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Saito H
Department Of Pharmacology College Of Pharmacy Nihon University
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Saito Hiroshi
Department Of Cardiovascular Medicine Osaka University Graduate School Of Medicine
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Matsuki Norio
Laboratory Of Chemical Pharmacology Graduate School Of Pharmaceutical Sciences The University Of Tok
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Saito Hiroshi
Department of Applied Chemistry, Graduate School of Engineering, Tohoku University
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