Oseltamivir Enhances Hippocampal Network Synchronization
スポンサーリンク
概要
- 論文の詳細を見る
Oseltamivir, a widely used anti-influenza drug, inhibits virus neuraminidase. A mammalian homologue of this enzyme is expressed in the brain, yet the effect of oseltamivir on central neurons is largely unknown. Patch-clamp recordings ex vivo revealed that oseltamivir enhanced spike synchronization between hippocampal CA3 pyramidal cells. Time-lapse multineuron calcium imaging revealed that oseltamivir and its active metabolite evoked synchronized population bursts that recruited virtually all neurons in the network. This unique, so-far-unknown, event was attenuated by muscarinic receptor antagonist. Thus, oseltamivir is a useful tool for investigating a new aspect of neural circuit operation.
- 社団法人 日本薬理学会の論文
- 2008-04-20
著者
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柴崎 正勝
東大 大学院
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松本 直章
東京大学大学院農学生命科学研究科獣医臨床病理学教室
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IKEGAYA Yuji
Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Science, The University of To
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Ikegaya Yuji
Lab. Of Chemical Pharmacology Graduate School Of Pharmaceutical Sciences The Univ. Of Tokyo Jpn
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Ikegaya Yuji
Laboratory Of Chemical Pharmacology Graduate School Of Pharmaceutical Sciences The Universe Of Tokyo
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Ikegaya Yuji
Laboratory Of Chemical Pharmacology Graduate School Of Pharmaceutical Science The University Of Toky
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Matsuki Norio
Lab. Of Chemical Pharmacology Graduate School Of Pharmaceutical Sciences The Univ. Of Tokyo Jpn
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Matsuki N
Univ. Tokyo Tokyo Jpn
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Matsuki Norio
Laboratory Of Chemical Pharmacology Graduate School Of Pharmaceutical Sciences The Universe Of Tokyo
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Matsuki Norio
Laboratory Of Chemical Pharmacology Graduate School Of Pharmaceutical Sciences The University Of Tok
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金井 みち子
Finnigan Mat Instruments Inc.
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USAMI Atsushi
Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, The University of T
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SASAKI Takuya
Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, The University of T
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Usami Atsushi
Laboratory Of Chemical Pharmacology Graduate School Of Pharmaceutical Sciences The University Of Tok
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Sasaki Takuya
Laboratory Of Chemical Pharmacology Graduate School Of Pharmaceutical Sciences The University Of Tok
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Matsuki Norio
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences
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Matsuki Norio
Graduate School Of Pharmaceutical Sciences The University Of Tokyo
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金井 求
Graduate School Of Pharmaceutical Sciences The University Of Tokyo
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Akiba Takahiro
Laboratory Of Synthetic Natural Products Chemistry Graduate School Of Pharmaceutical Sciences The Un
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Fukuyama Tohru
Laboratory Of Synthetic Natural Products Chemistry Graduate School Of Pharmaceutical Sciences The Un
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SATOH Nobuhiro
Laboratory of Synthetic Natural Products Chemistry, Graduate School of Pharmaceutical Sciences, The
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YOKOSHIMA Satoshi
Laboratory of Synthetic Natural Products Chemistry, Graduate School of Pharmaceutical Sciences, The
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YAMATSUGU Kenzo
Laboratory of Synthetic Organic Chemistry, Graduate School of Pharmaceutical Sciences, The Universit
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KANAI Motomu
Laboratory of Synthetic Organic Chemistry, Graduate School of Pharmaceutical Sciences, The Universit
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SHIBASAKI Masakatsu
Laboratory of Synthetic Organic Chemistry, Graduate School of Pharmaceutical Sciences, The Universit
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Yamatsugu Kenzo
Laboratory Of Synthetic Organic Chemistry Graduate School Of Pharmaceutical Sciences The University
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Satoh Nobuhiro
Laboratory Of Synthetic Natural Products Chemistry Graduate School Of Pharmaceutical Sciences The Un
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Yokoshima Satoshi
Laboratory Of Synthetic Natural Products Chemistry Graduate School Of Pharmaceutical Sciences The Un
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Matsuki Norio
Laboratory Of Chemical Pharmacology Graduate School Of Pharmaceutical Sciences The University Of Tok
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Matsuki Norio
Laboratory Of Chemical Pharmacology Graduate School Of Pharmaceutical Sciences The University Of Tok
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Matsuki Norio
Laboratory Of Chemical Pharmacology Graduate School Of Pharmaceutical Sciences The University Of Tok
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Matsuki Norio
Laboratory Of Chemical Pharmacology Graduate School Of Pharmaceutical Sciences The University Of Tok
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Matsuki Norio
Laboratory Of Chemical Pharmacology Graduate School Of Pharmaceutical Sciences The University Of Tok
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池田 友子
Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, The University of Tokyo
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