Effects of Astemizole on Ventricular Activation Delay and RT Intervals in a Canine Myocardial Infarction Model
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概要
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In order to clarify the arrhythmogenic effects of nonsedating antihistamines, we examined the effects of astemizole, a nonsedating antihistamine, on ventricular activation and RT intervals in a canine myocardial infarction model. Myocardial infarction was produced by two-stage ligation of the left anterior descending coronary artery in dogs. Seven days after ligation, bipolar electrodes were sutured on the ventricular surface of the infarcted and normal zones to apply an electrical stimulation or record the ventricular activation. An electrical stimulation with coupling intervals between 300 and 140 ms was applied on the ventricular surface of the normal zone during atrial pacing, and the ventricular activation delay was measured. The effect of astemizole on the RT interval was also determined during atrial pacing, sinus rhythm or after premature stimulation. The ventricular activation delay increased after astemizole at doses of 0.3 to 3 mg/kg in the infarcted and at 3 mg/kg in the normal zones, and the effect of astemizole was greater in the infarcted zone. Astemizole increased the RT interval in the normal zone to a greater extent at a long coupling interval. The increase in the RT interval was greater in the infarcted zone compared with that in the normal zone. In conclusion, astemizole increased the activation delay in the infarcted zone, probably through prolongation of the repolarization time, and its effect on the activation delay may be arrhythmogenic.
- 公益社団法人日本薬学会の論文
- 1997-09-15
著者
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NAKASHIMA MITSUYOSHI
Department of Pharmacology, Hamamatsu Medical College
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Hayashi Hideharu
浜松医科大学 医学部内科学第三
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Umemura Kazuo
Department of Pharmacology, Hamamatsu University School of Medicine, Japan
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Ohashi Kyoichi
Department of Clinical Pharmacology and Therapeutics, Hamamatsu University School of Medicine
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Ikegaya Yuji
Lab. Of Chemical Pharmacology Graduate School Of Pharmaceutical Sciences The Univ. Of Tokyo Jpn
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Watanabe S
Tsukuba Research Laboratories Eisai Co. Ltd.
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HASHIMOTO Hisakuni
Hospital Pharmacy, Hamamatsu University School of Medicine
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WATANABE Shinji
Hospital Pharmacy, Hamamatsu University School of Medicine
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Nishimoto Masahiro
Faculty Of Pharmaceutical Sciences Osaka University
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西本 昌弘
Faculty Of Pharmaceutical Sciences Osaka University
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Nakashima Mitsuyoshi
Deparrment Of Pharmacology Hamamatsu University School Of Medicine
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Watanabe S
Eisai Co. Ltd. Ibaraki Jpn
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NISHIMOTO Masahiko
Department of Clinical Pharmacology, Hamamatsu University School of Medicine
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OHMURA Tomohiro
Hospital Pharmacy, Hamamatsu University School of Medicine
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IKEDA Yasuhiko
Department of Pharmacology, Hamamatsu University School of Medicine
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Umemura K
Soka Univ. Tokyo Jpn
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Umemura Kazuo
Department Of Environmental Energy Engineering Faculty Of Engineering Musashi Institute Of Technolog
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Ohashi Kyoichi
Department Of Clinical Pharmacology
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Nishimoto M
Faculty Of Pharmaceutical Sciences Osaka University
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Ikeda Yasuhiko
Department Of Pharmacology Hamamatsu University School Of Medicine
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Hashimoto Hisakuni
Hospital Pharmacy Hamamatsu University School Of Medicine
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Hashimoto Hisakuni
Department Of Pharmacology Hamamatsu University School Of Medicine
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Umemura Kazuo
Departmen T Of Pharmacology
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Hashimoto H
Hamamatsu Univ. Hamamatsu Jpn
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池田 友子
Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, The University of Tokyo
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