Electrophysiologic Effects of Nitrous Oxide, a Volatile Anesthetic, in Dogs Following Myocardial Infarction in Comparison with Other Anesthetics
スポンサーリンク
概要
- 論文の詳細を見る
The present study was undertaken to examine the electrophysiologic effects of nitrous oxide in the dog heart after inducing myocardial infarction, and to compare these with those of other anesthetics. Myocardial infarction was produced by two-stage ligation of the left anterior descending coronary artery in dogs. Seven days after ligation, bipolar electrodes were sutured on the ventricular surface of the infarcted and normal regions for applying electrical stimulation or recording ventricular activation. Ventricular activation time and QT interval on the bipolar electro-cardiogram and PQ interval from the standard limb lead II were measured during atrial pacing. Nitrous oxide 80% did not significantly prolong ventricular activation time, PQ interval or QT interval. However, halothane 1 minimum alveolar concentration (MAC), thiopental 5 and 10 mg/kg and fentanyl 30 μg/kg did prolong ventricular activation time; thiopental and fentanyl prolonged the QT interval. Nitrous oxide did not potentiate the effects of fentanyl. Therefore, electrophysiologic effects of nitrous oxide are much weaker compared with those of thiopental, fentanyl or halothane.
- 社団法人日本薬学会の論文
- 1997-01-15
著者
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Ikeda Kazuyuki
Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University
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NAKASHIMA MITSUYOSHI
Department of Pharmacology, Hamamatsu Medical College
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Hayashi Hideharu
浜松医科大学 医学部内科学第三
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Watanabe S
Tsukuba Research Laboratories Eisai Co. Ltd.
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Ikeda Kazuyuki
Department Of Anesthesiology Hamamatsu University School Of Medicine
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HASHIMOTO Hisakuni
Hospital Pharmacy, Hamamatsu University School of Medicine
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IMAMURA Satoshi
Department of Anesthesiology, Hamamatsu University School of Medicine
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WATANABE Shinji
Hospital Pharmacy, Hamamatsu University School of Medicine
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OOMURA Tomohiro
Hospital Pharmacy, Hamamatsu University School of Medicine
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SUZUKI Yoshinari
Hospital Pharmacy, Hamamatsu University School of Medicine
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Suzuki Yoshinari
Hospital Pharmacy Hamamatsu University School Of Medicine
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Nishimoto Masahiro
Faculty Of Pharmaceutical Sciences Osaka University
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西本 昌弘
Faculty Of Pharmaceutical Sciences Osaka University
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Nakashima Mitsuyoshi
Deparrment Of Pharmacology Hamamatsu University School Of Medicine
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Watanabe S
Eisai Co. Ltd. Ibaraki Jpn
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Nishimoto M
Faculty Of Pharmaceutical Sciences Osaka University
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Ikeda Kazuyuki
Department Of Anesthesiology And Intensive Care Hamamatsu University School Of Medicine
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Imamura Satoshi
Department Of Anesthesiology Hamamatsu University School Of Medicine
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Hashimoto Hisakuni
Hospital Pharmacy Hamamatsu University School Of Medicine
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Hashimoto Hisakuni
Department Of Pharmacology Hamamatsu University School Of Medicine
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Hashimoto H
Hamamatsu Univ. Hamamatsu Jpn
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