Effect of Calcium Antagonists on the Electrical Alternans of the ST Segment during Acute Coronary Occlusion in Dogs
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概要
- 論文の詳細を見る
Effects of calcium antagonists on the ST alternans during acute coronary occlusion were examined in dogs. The intravenous administration of verapamil at doses of 0.1mg/Kg and 0.2mg/Kg prominently attenuated the degree of ST alternans. Diltiazem at dose of 0.2mg/Kg also attenuated the degree of alternans. Dipyridamole at dose of 0.5mg/Kg did not significantly attenuate the degree of alternans. Verapamil significantly inhibited the ST-segment elevation. After verapamil, ST alternans did not occur even after a longer period of occlusion when changes in QRS complex and the ST-segment elevation were remarkable. It is possible that verapamil inhibits ST alternans by both the protecting effect against ischemic injury and a direct effect on the electrical activity of the myocardial cell membrane.
- International Heart Journal刊行会の論文
著者
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Nakashima Mitsuyoshi
Deparrment Of Pharmacology Hamamatsu University School Of Medicine
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Hashimoto Hisakuni
Department Of Pharmacology Hamamatsu University School Of Medicine
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Suzuki Kunifumi
Department Of Psychiarty School Of Medicine Nagoya University
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MIYAKE Shinya
Department of Pharmacology, Hamamatsu University School of Medicine
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HASHIMOTO Hisakuni
Department of Pharmacology, Hamamatsu University School of Medicine
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SUZUKI Kunifumi
Department of Pharmacology, Hamamatsu University School of Medicine
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