Changes in the effects of clonidine on left atrium and hindlimb vasculature of rats in various thyroid states. A study of the responsiveness of .ALPHA.2-adrenoceptors in the cardiovascular system.:A Study of the Responsiveness of α2-Adrenoceptors in the C

スポンサーリンク

概要

• 論文の詳細を見る

• Postsynaptic α2-adrenoceptors have been reported to exist in various tissues, including vascular smooth muscle. In order to investigate the possibility of their mediating a positive inotropic change and clarify the influence of the thyroid on their responsiveness, we examined the effects of clonidine, a known α2-agonist, on the isolated left atria and femoral vascular beds of rats which were made hypo-, hyper- or euthyroid. Clonidine caused a dose-dependent positive inotropic change in the hypothyroid rat atrium, which was thought to be due to its α1-stimulating action because of the antagonistic effect exerted by either phentolamine (10-6M) or prazosin (10-7M), but not by yohimbine (10-7M) or cimetidine (10-5M). In the hyperthyroid rat atrium, clonidine exerted a negative inotropic effect at high concentrations, which was thought to be due to its direct action on the cardiac muscle. Clonidine did not cause any inotropic change in the euthyroid rat atrium. Thus, an inotropic change mediated by the postsynaptic α2 adrenoceptors could not be demonstrated in the rat heart. In the experi-ment involving hindlimb perfusion, clonidine caused vasoconstriction which was antagonized by yohimbine (10μg/min). This effect was significantly augmented in the hypothyroid rats but not changed in the hyperthyroid ones. The vasoconstrictive effect of phenylephrine was found to be reduced in both hypo- and hyperthyroid rats. These results suggest that, in the peripheral vascular system, thyroid function also influences the postsynaptic α2-adrenoceptors, but not in the same way as it affects the α1-adrenoceptors.

• International Heart Journal刊行会の論文

著者

• Sotobata Iwao

  First Dep. Of Intern. Med. Nagoya Univ.

• Nakashima Mitsuyoshi

  Deparrment Of Pharmacology Hamamatsu University School Of Medicine

• OGURO Katsunori

  Department of Pharmacology and Experimental Therapeutics, Tohoku University School of Medicine

• OHGUCHI Sadao

  First Department of Internal Medicine, Nagoya University School of Medicine,

• SOTOBATA Iwao

  First Department of Internal Medicine, Nagoya University School of Medicine,

関連論文

• The Japanese Society of Hypertension Committee for Guidelines for the Management of Hypertension
• PHARMACOKINETICS OF PLASMA AND URINE CLENBUTEROL IN MAN, RAT, AND RABBIT
• Clinical Effects of Rosuvastatin, a New HMG-CoA Reductase Inhibitor, in Japanese Patients With Primary Hypercholesterolemia : an Early Phase II Study
• -101- THE EFFECTS OF VASODILATING AGENTS ON VENOUS TONE IN VIVO IN THE DOG : Pulmonary Circulation, Papillary Circulation : FREE COMMUNICATIONS(I) : PROCEEDINGS OF THE 51th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
• ASSESSMENT OF THE INDEXES OF THE LEFT VENTRICULAR ISOVOLUMIC RELAXATION FORM PRESSURE FALL : Ventricular Function : PROCEEDINGS OF THE 50th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
• -347-THE ANALYSIS OF IN VIVO VENOUS TONE IN DOGS
• Effect of Low Grade Exercise Training and a Vasodilator on Cardiac Function in Patients with Recent Myocardial Infarction : 53rd Annual Scienific Seeesion of the Japanese Circulation Society
• A randomized open-label comparative study of conventional therapy versus mizoribine onlay therapy in patients with steroid-resistant nephrotic syndrome (postmarketing survey)
• -385- A STUDY ON BLOOD COAGULABILITY AND FIBRINOLYTIC ACTIVITY BEFORE AND AFTER REHABILITATION IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION
• -384- EFFECTS OF TREADMILL EXERCISE ON T-RA, PROTEIN C, FRA, EPBβ-15-42 AND D-DIMER IN PATIENTS WITH ISCHEMIC HEART DISEASE AND NORMAL SUBJECTS
• THE CLINICAL IMPLICATION OF LATE VENTRICULAR POTENTIALS IN PATIENTS WITH OLD MYOCARDIAL INFARCTION : Arrhythmias, Clinical : PROCEEDINGS OF THE 50th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
• -208-EVALUATION OF ANTIARRHYTHMIC DRUG TAKING ACCOUNT OF THE PHARMACODYNAMICS WITH AN AMBULATORY ECG
• Prescription for Rehabilitative Two-step Exercise with a Low-level Treadmill Exercise Testing in Cardiac Patients : Cardiac Rehabilitation
• -0078- The Response of Left Ventricular Relaxation to Tachycardia in Hypertrophied Hearts(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY)
• Long-term Effects of Nifedipine Retard vs ACE Inhibitors in Hypertension with Coronary Artery Disease : Final Reports of J-MIC(B)
• -P118-ENDOTHELIN ENHANCES ADRENERGIC VASOCONSTRICTION IN RAT : Hypertension : FREE COMMUNICATIONS(III) : PROCEEDINGS OF THE 53th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
• BLOOD PRESSURE RESPONSE TO [1-SARCOSINE, 8-ISOLEUCINE]ANGIOTENSIN II IN PATIENTS WITH LIVER CIRRHOSIS AND ASCITES
• -394- CLINICAL SIGNIFICANCE OF LEFT ATRIAL DIMENSION MEASUREMENTS DURING SUPINE BICYCLE ERGOMETER EXERCISE TESTINGS
• -383- EARLY RECOGNITION OF EXERCISE-INDUCED MYOCARDIAL ISCHEMIA BY PLASMA FREE FATTY ACIDS (FFA)
• PRODUCTION OF AORTIC INSUFFICIENCY OR MYOCARDIAL INFARCT IN THE RAT AND SUBSEQUENT MYOCARDIAL HYPERTROPHY : CHANGES IN ADRENOCEPTORS WITH SPECIAL REFERENCE TO THE RELATION BETWEEN RECEPTOR DENSITY AND CONTRACTILE RESPONSE
• Randomized Double-Blind Trial of Intracoronary Urokinase for Acute Myocardial Infarction : Multicenter Study : 50th Annual Scientific Session of the Japanese Circulation Society
• Electrophysiologic Effects of Nitrous Oxide, a Volatile Anesthetic, in Dogs Following Myocardial Infarction in Comparison with Other Anesthetics
• EFFECTS OF TREADMILL AND HANDGRIP EXERCISE ON BLOOD COAGULABILITY AND PLATELET FUNCTION IN PATIENTS WITH ISCHEMIC HEART DISEASE : Excercise Test : IV : 48 Annual Scientific Meeting, Japanese Circulation Society
• EXPERIMENTAL STUDY OF SICK SINUS SYNDROME (SSS). RELATIONSHIP BETWEEN AUTOMATICITY AND LOCATION OF PACEMAKER : Arrhythmia I, Immunity & Heredity, Contractile Protein : IVth Auditorium : Proceedings of the 43rd Annual Meeting of the Japanese Circulation So
• INFLUENCE OF RISK FACTORS ON LONG TERM SURVIVAL AFTER ACUTE MYOCARDIAL INFARCTION : Ischemic Heart Disease (VI) : FREE COMMUNICATIONS (VI) : PROCEEDINGS OF THE 49th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
• REPRODUCIBILITY OF EXERCISE TOLERANCE IN PATIENTS WITH EFFORT ANGINA : PROCEEDINGS OF THE 47th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY : Exercise Test
• LOCALIZATION OF THE SITE OF THE VENTRICULAR ENTRY OF THE ACCESSORY PATHWAY USING THE PHASE IMAGE IN WOLFF-PARKINSON-WHITE SYNDROME : PROCEEDINGS OF THE 47th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY : Radioisotope
• 16) ESTIMATION OF THE SITE OF ORIGIN OF VENTRICULAR PREMATURE BEAT BY VCG AND BODY SURFACE ISOPOTENTIAL MAP
• 13) A CORRELATIVE STUDY BETWEEN FRANK VECTORCARDIOGRAMS AND Tl-201 MYOCARDIAL EMISSION CT SCANS IN PATIENTS WITH OLD MYOCARDIAL INFARCTION
• DISTRIBUTION OF ABNORMAL Q WAVES ON BODY SURFACE IN RELATION TO LEFT VENTRICULAR WALL MOTION ABNORMALITIES IN MYOCARDIAL INFARCTION : Mapping : 46th Annual Scientific Meeting, Japanese Circulation Society
• -465- INHIBITORY ACTION OF FLECAINIDE ON SODIUM CHANNELS OF ISOLATED GUINEA PIG VENTRICULAR MUSCLES
• Clinical Study of Vectocardiograms of Right Ventricular Volume and Pressure Overloadings in Congenital Heart Disease
• Vectorcardiographic Studies of Right Ventricular Hypertrophy by Means of SVEC III System
• EFFECTS ON ISOTONIC AND ISOMETRIC EXERCISES ON PLATELET FUNCTION AND BLOOD COAGULABILITY IN HEALTHY MEN : PROCEEDINGS OF THE 47th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY : Exercise Test
• The Quantitative Diagnosis of Thallium-201 Myocardial Perfusion Images and Vectorcardiograms in Myocardial Infarction and Hypertrophic Cardiomyopathy : The Present Status of Cordiovascular Nuclear Medicine
• 6)RESPIRATORY CHANGES IN NORMAL FRANK VECTORCARDIOGRAPHIC P LOOP : THE II CONFERENCE ON VECTORCARDIOGRAPHY
• -556- EVALUATION OF LEFT VENTRICULAR FUNCTION AFTER PHYSICAL TRAINING USING EXERCISE STRESS RADIONUCLIDE VENTRICULOGRAPHY (RNV) IN PATIENTS IN THE RECOVERY PHASE OF ACUTE MYOCARDIAL INFARCTION (AMI)
• -371- HEMODYNAMIC DETERMINANT FACTOR OF EXERCISE TOLERANCE IN PATIENTS WITH PRIOR MYOCARDIAL INFARCTION
• -366- LOCATION OF CORONARY LESION USING THE MULTIPLE UNIPOLAR PRECORDIAL LEADS EXERCISE TESTING : INVESTIGATION OF THE SITES OF THE MAXIMAL ST DEPRESSION CORRECTED BY THE R-WAVE AMPLITUDE
• -P89- FOURIER ANALYSIS OF LV VOLUME CURVE IN PATIENTS WITH ARTIFICIAL VENTRICULAR PACEMAKERS : FPRWARD AND BACKWARD GATED POOL IMAGING : RI : FREE COMMUNICATIONS(I) : PROCEEDINGS OF THE 51th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
• -P24- DIAGNOSTIC USEFULNESS OF QRST ISO-INTEGRAL MAP IN PATIENTS WITH MYOCARDIAL INFARCTION ASSOCIATED WITH BUNDLE BRANCH BLOCK : ECG, Mapping : FREE COMMUNICATIONS(I) : PROCEEDINGS OF THE 51th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
• -142-EVALUATION OF LEFT VENTRICULAR FUNCTION IN PATIENTS WITH VENTRICULAR PREMATURE CONTRACTIONS BY PULSED DOPPLER ECHOCARDIOGRAPHY
• -119-EFFECTS OF CALCIUM ANTAGONISTS ON SERUM β-METHYLDIGOXIN CONCENTRATION
• -109-THE EFFECT OF EXERCISE THERAPY ON CARBOHYDRATE AND LIPID METABOLISM
• DISTRIBUTION OF BODY SURFACE POTENTIAL IN COMPLETE LEFT BUNDLE BRANCH BLOCK (CLBBB) WITH VARIOUS UNDERLYING HEART DISEASES : Arrhythmias (II), Electrophysiology (II), Mapping : III : 48 Annual Scientific Meeting, Japanese Circulation Society
• -1048-ENDOTHELIN RELEASE FORM PERFUSED RAT MESENTERIC ARTERY ENHANCED BY HYPOXIA : THE 54th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
• THE EFFECT OF AGE ON ACTIVE AND CRYOACTIVATABLE INACTIVE PLASMA RENIN IN NORMAL SUBJECTS AND PATIENTS WITH ESSENTIAL HYPERTENSION
• -272-STUDIES ON PATHOGENESIS OF HYPERTENSION AND BLOOD PRESSURE MAINTENANCE IN HUMAN BY THE USE OF ANGIOTENSIN II ANALOGUES : Renin,Angiotensin : PROCEEDINGS OF THE 42nd ANNUAL MEETING OF THE JAPANESE CIRCULATION SOCIETY
• Phase I Clinical Studies of S-1090: Safety and Pharmacokinetics
• -441- HEMODYNAMIC, RENAL AND HORMONAL EFFECTS OF α-HUMAN ATRIAL NATRIURETIC PEPTIDE INJECTION IN PATIENTS WITH CONGESTIVE HEART FAILURE
• A Placebo-Controlled, Single-Blind Study to Determine the Appropriate Alendronate Dosage in Postmenopausal Japanese Patients with Osteopotosis
• -P121-ENDOTHELIN INHIBITS RENIN RELEASE FROM ISOLATED RAT GLOMERULI : Hypertension : FREE COMMUNICATIONS(III) : PROCEEDINGS OF THE 53th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
• EFFECT OF CAPTOPRIL ON RENAL VASCULAR RESISTENCE, RENIN, PROSTAGLANDINS AND KININ IN THE ISOLATED PERFUSED KIDNEY : PROCEEDINGS OF THE 47th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY : Hypertension
• EFFECT OF AGING ON 6-keto-PGF_ LEVELS IN NORMOTENSIVE AND ESSENTIAL HYPERTENSIVE MALES
• HYPOTENSIVE ACTIVITY OF SYNTHETIC RENOMEDULLARY ANTIHYPERTENSIVE LIPID, 1-0-HEXADECYL-2-0-ACETYL-SN-GLYCERO-3-PHOSPHOCHOLINE : Hypertension (I) : 46th Annual Scientific Meeting, Japanese Circulation Society
• THE PESPONSES OF ACTIVE AND INACTIVE PLASMA RENIN TO VARIOUS CONDITIONS AND THE POSSIBLE ROLE OF PLASMA OR RENAL KALLIKREIN IN ACTIVATION OF INACTIVE RENIN : Kidney・Hypertension : FREE COMMUNICATIONS (Abstract) : 45 Annual Scientific Meeting, Japanese Cir
• Difference in the Incidence of Cough Induced by Angiotensin Converting Enzyme Inhibitors: a Comparative Study Using Imidapril Hydrochloride and Enalapril Maleate
• An Experimental Myocardial Infarction Model in the Rat and Its Properties
• MICROCOMPUTER-ASSISTED VECTORCARDIOGRAPHIC ANALYSIS : PROCEEDINGS OF THE 47th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY : Vectorcardiography Mapping
• EXERCISE-INDUCED U-WAVE INVERSION IN MULTIPLE UNIPOLAR PRECORDIAL LEADS IN EFFORT ANGINA PECTORIS : PROCEEDINGS OF THE 47th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY : Exercise Test
• THE CLINICAL SIGNIFICANCE OF HEMOGLOBIN OXYGEN DISSOCIATION CURVE IN PATIENTS WITH CONGESTIVE HEART FAILURE : PROCEEDINGS OF THE 47th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY : Heart Failure
• VCG DIFFERENTIAL DIAGNOSIS BETWEEN PREMATURE VENTRICULAR CONTRACTION AND ABERRANT VENTRICULAR CONDUCTION : Vectorcardiography : 46th Annual Scientific Meeting, Japanese Circulation Society
• EFFECTS OF TREADMILL EXERCISE ON HEMOGLOBIN AFFINITY FOR OXYGEN IN NORMAL SUBJECTS : Exercise Test : 46th Annual Scientific Meeting, Japanese Circulation Society
• Effects of Astemizole on Ventricular Activation Delay and RT Intervals in a Canine Myocardial Infarction Model
• ASSESSMENT OF LEFT HEART FUNCTION DURING EFFORT ANGINA PECTORIS USING P LOOP ANALYSIS OF EXERCISE VECTORCARDIOGRAPHY : PROCEEDINGS OF THE 47th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY : Vectorcardiography Mapping
• Effect of Argatroban on Microthrombi Formation and Brain Damage in the Rat Middle Cerebral Artery Thrombosis Model
• Inhibitory Effect of Clopidogrel, Vapiprost and Argatroban on the Middle Cerebral Artery Thrombosis in the Rat
• Altered Prostaglandin Metabolism Induced by Angiotensin-Converting Enzyme Inhibitors in Broncho-Alveolar Lavage Fluid of the Guinea Pig
• Present Status of Exercise Testing in the Evaluation of Coronary Artery Disease : Present Status and Future of Clinical Electrocardiology
• Sex and Age Differences of Normal P Loops in the Frank Lead Vectorcardiogram
• -66-EFFECTS OF A NEW CLASS I ANTIARRHYTHMIC AGENT SA3212 ON ARRHYTHMIA OCCURED 24 HOURS AFTER THE CORONARY LIGATION AND INTRAVENTRICULAR DELAYED CONDUCTION 7 DAYS AFTER THE LIGATION IN CANINE : Arrhythmias : FREE COMMUNICATIONS(I) : PROCEEDINGS OF THE 53t
• Effects of antiarrythmic drugs on excitation and conduction abnormalities in various stages of myocardial ischemia in experimental animals
• Non-invasive Localization of the Pre-excitation Site in Patients with the Wolff-Parkinson-White Syndrome : Vectorcardiographic and Echocardiographic Correlations
• Optimal dosage and differences in therapeutic efficacy of IGIV in Kawasaki disease
• Comparison of Frank-Vectorcardiograms of Normal Conduction and Right Bundle Branch Block in Patients with Intermittent or Transient Right Bundle Branch Block
• Respiratory Changes of the P Loop in the Frank Vectorcardiogram
• INFLUENCE OF HYPOTHYROID STATUS ON DOPAMINEIN-DUCED POSITIVE CHRONOTROPIC AND INOTROPIC EFFECTS ON ISOLATED RAT ATRIA
• ANTI-ARRHYTMIC EFFECT OF NADOLOL IN EXPERIMENTAL ARRHYTHMIAS : COMPARISON WITH PROPRANOLOL AND ALPRENOLOL
• STIMULANT ACTION OF METHOXAMINE IN THE ISOLATED ATRIA OF NORMAL AND 6-PROPYL-2-THIOURACIL-FED RATS
• Influences of the Alteration in Aortic Pressure on Regional Myocardial Function and Regional Myocardial Blood Flow in Partial Coronary Artery Occlusion
• ADRENERGIC RECEPTORS IN RAT LIVER : II. EFFECTS OF PHENYLEPHRINE, ISOPROTERENOL AND ADRENERGIC BLOCKING AGENTS ON GLUCONEOGENESIS IN PERFUSED LIVER
• ADRENERGIC RECEPTORS IN RAT LIVER : I. EFFECTS OF EPINEPHRINE AND ADRENERGIC BLOCKING AGENTS ON GLUCONEOGENESIS IN PERFUSED LIVER
• Clinical Evaluation of a New Formula of Timolol Maleate (WP-934 Ophthalmic Solution)
• EVIDENCE FOR THE EXISTENCE OF ALPHA ADRENERGIC RECEPTOR IN ISOLATED RAT ATRIA
• EFFECT OF HYPOTHYROID STATUS ON MYOCARDIAL RESPONSES TO SYMPATHOMIMETIC DRUGS
• Experimental Studies and Clinical Report on the Electrical Alternans of ST Segment during Myocardial Ischemia
• Effect of Calcium Antagonists on the Electrical Alternans of the ST Segment during Acute Coronary Occlusion in Dogs
• The Vectorcardiographic Study of the P Loop in Adults with Ostium Secundurn Atrial Septal Defect
• STUDIES ON THE VASCULAR ACTION OF BRADYKININ
• Effects of 2-((5-chloro-2-methoxyphenyl)azo)-1H-imidazole (M6434) on alpha adrenergic receptors.
• Noninvasive Evaluation of Cardiovascular Effects of β-Adrenergic Blockers with Different Pharmacological Properties
• Effects of treadmill exercise on platelet function, blood coagulability and fibrinolytic activity in patients with atrial fibrillation.
• Electrophysiologic Interaction between Class I Antiarrhythmic Drugs and Volatile Anesthetics in Depressant Effects on Ventricular Activation in a Canine Myocardial Infarction Model.
• Changes in plasma level of alpha-atrial natriuretic polypeptide (alpha-ANP) and responsiveness of the aorta to exogenous alpha-ANP subsequent to myocardial infarction in rats.
• Changes in vascular responsiveness to vasoactive agents in the hindlimb of DOCA-salt hypertensive rats.
• Analysis of the exercise-induced orthogonal P wave changes in normal subjects and patients with coronary artery disease.
• Effects of treadmill exercise on platelet functions and blood coagulating activities in healthy men.
• Changes in the effects of clonidine on left atrium and hindlimb vasculature of rats in various thyroid states. A study of the responsiveness of .ALPHA.2-adrenoceptors in the cardiovascular system.:A Study of the Responsiveness of α2-Adrenoceptors in the C
• Plasma .BETA.-Thromboglobulin and platelet factor 4 concentrations in patients with atrial fibrillation.
• Evaluation of myocardial involvement in Duchenne's progressive muscular dystrophy with thallium-201 myocardial perfusion imaging.

もっと見る 閉じる

スポンサーリンク