ANTI-ARRHYTMIC EFFECT OF NADOLOL IN EXPERIMENTAL ARRHYTHMIAS : COMPARISON WITH PROPRANOLOL AND ALPRENOLOL
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概要
- 論文の詳細を見る
The effects of nadolol on experimental arrhythmias were investigated and compared with those of propranolol and alprenolol. The arrhythmias were induced by either ouabain, holothane plus adrenaline or acute coronary occlusion in anesthetized dogs. All three β-blocking drugs in a does range of 10 to 200μg/kg inhibited halothane plus adrenaline-induced arrhythmias. These drugs also attenuated coronary occlusion-induced ventricular arrhythmias as well as other electrical abnormalities such as electrical alternation and conduction delay. Among the three drugs, nadolol was the most potent in suppressing both types of arrhythmias. Contrary to the potent effects on these arrhythmias, nadolol was ineffective against ouabain-induced arrhythmias even in a dose of 3 mg kg, while propranolol and alprenolol were significantly effective in a dose of 100μg/kg. It is probable that the anti-arrhythmic effect of nadolol is exclusively due to its β-blocking activity.
- 公益社団法人日本薬学会の論文
著者
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Hayashi Hideharu
浜松医科大学 医学部内科学第三
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Nakashima Mitsuyoshi
Deparrment Of Pharmacology Hamamatsu University School Of Medicine
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Sogabe K
Department Of Pharmacology Hamamatsu University School Of Medicine
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Takiguchi Y
Univ. Tokushima Fac. Pharmaceutical Sci.
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Takiguchi Yoshiharu
Department Of Clinical Pharmacology Institute Of Health Biosciences The University Of Tokushima Grad
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Nakashima Mitsuyoshi
浜松医科大学 薬理
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Hashimoto Hisakuni
Hospital Pharmacy Hamamatsu University School Of Medicine
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Hashimoto Hisakuni
Department Of Pharmacology Hamamatsu University School Of Medicine
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OGURO KATSUNORI
Department of Pharmacology, Hamamatsu University School of Medicine
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SOGABE KEIZO
Department of Pharmacology, Hamamatsu University School of Medicine
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Oguro K
Department Of Pharmacology Hamamatsu University School Of Medicine
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Hashimoto H
Hamamatsu Univ. Hamamatsu Jpn
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OGURO Katsunori
Department of Pharmacology and Experimental Therapeutics, Tohoku University School of Medicine
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