EFFECT OF AGING ON 6-keto-PGF_<1α> LEVELS IN NORMOTENSIVE AND ESSENTIAL HYPERTENSIVE MALES
スポンサーリンク
概要
- 論文の詳細を見る
Prostacyclin (PGI_2) is produced in the vessel wall and acts as a vasodilator hormone. Measurement of plasma 6-keto-PGF_<1α> is considered to be an index of PGI_2 production. In the present study the effects of aging on the plasma 6-keto-PGF_<1α> levels were studied in 64 normotensive and 48 essential hypertensive males. The subjects were divided into 3 groups, i.e., young (24-39 years), middle-aged (40-55 years) and elderly (over 56 years) groups. Plasma 6-keto-PGF_<1α> was measured by specific radioimmunoassay after silicic acid column chromatographic purification. The 6-keto-PGF_<1α> levels were lower in elderly normotensive males (10.3 ± 1.4 pg/ml, mean ± SE, n=12) than in normotensive young males (15.3± 2.3 n=30, p < 0.05). The plasma 6-keto-PGF_<1α> levels in hypertensive elderly males (10.6 ± 1.3 pg/ml, n=10) is lower than in hypertensive young males (19.8 ± 2.2, n=17, p<0.01). These results indicate that the plasma 6-keto-PGF_<1α> levels decreased with age in both normotensive and hypertensive groups. Thus, PGI_2 production may decrease with age.
- 社団法人日本循環器学会の論文
- 1983-03-20
著者
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NARUSE Mitsuhide
NHO Kyoto Medical Center
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OGIHARA Toshio
Department of Geriatric Medicine, Osaka University Graduate School of Medicine
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Nakamaru Mitsuaki
Nho Kyoto Medical Center
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HATA Takeshi
Department of Material Chemistry, Graduate School of Engineering, Kyoto University
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NAGASE Mitsumasa
Teikyo University School of Medicine
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Ogihara Toshio
Department Of Geriatic Medicine
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Kumahara Yuichi
Department of Medicine and Geriatrics, Osaka University Medical School
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Hata Takeshi
Department Of Medicine And Geriatrics Osaka University Medical School
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Hata Takeshi
Department Of Biomolecular Engineering Graduate School Of Bioscience And Biotechnology Tokyo Institu
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MASUO Kazuko
Department of Geriatric Medicine, Osaka University Graduate School of Medicine
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Nakamaru Mitsuaki
Department of Ceriatric Medicine, Osaka University Medical School
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GOTOH Seiji
Department of Medicine and Geriatrics, Osaka University Medical School
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Masuo Kazuko
Department Of Medicine And Geriatrics Osaka University Medical School
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Nakashima Mitsuyoshi
Deparrment Of Pharmacology Hamamatsu University School Of Medicine
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Gotoh Seiji
Department Of Medicine And Geriatrics Osaka University Medical School
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Gotoh Seiji
Department Of Cardiology Hanwa Memorial Hospital
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Masuo Kazuko
Department Of Geriatric Medicine Osaka University Graduate School Of Medicine
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Kumahara Yuichi
The Department Of Medicine And Geriatrics Osaka University Medical School
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Kumahara Yuichi
Department Of Medicine And Geriatrics Osaka University Medical School
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Kumahara Yuichi
Department Of Medicine And Ceriatrics Oska University Medical School
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Nagase Mitsumasa
Nho Kyoto Medical Center
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Kumahara Yuichi
Department Of Medicine And Geriatrics Osaka University Medical School:sakurabashi Watanabe Hospital
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Kumahara Yuichi
The Central Laboratory For Clinical Investigation Osaka Univ. Hosp. Osaka And The Center For Adult D
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Nakajima Mitsuyoshi
Deparrment Of Pharmacology Hamamatsu University School Of Medicine
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