Polymorphism of myospryn is associated with left ventricular diastolic dysfunction
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概要
- 論文の詳細を見る
BACKGROUND: With aging, left ventricle diastolic dysfunction due to pressure overload is an independent risk factor for morbidity and mortality. Mechanisms by which alterations in stretch-induced mechanotransduction contribute to left ventricular diastolic dysfunction remain unclear. Recently, since novel Z-disc related protein, myospryn, expressed in striated muscle cells, has been reported, we examined the relationship between myospryn polymorphisms and alterations in cardiac function with patients in larger population.METHODS: A total of 743 patients with high blood pressure (defined as systolic blood pressure >140 mmHg and/or systolic blood pressure >90 mmHg or taking antihypertensive medication) were enrolled in this study. Two-dimensional ultrasound echocardiography, electrocardiography, blood pressure, serum glucose, cholesterol, creatinine, uric acid, and myospryn K2906N polymorphism.RESULTS: The myospryn K2906N polymorphism was significantly associated with a marker of left ventricular diastolic cardiac dysfunction, A/E, which represents the ratio of the peak velocity of the early diastolic filling wave (E wave) to the atrial filling (A wave).CONCLUSIONS: These data demonstrated that a polymorphism of myospryn was associated with left ventricular diastolic dysfunction in hypertensive patients and provided the novel therapeutic target for cardiac adaptation in response to pressure overload as an anti-aging therapy.
- 一般社団法人 日本抗加齢医学会の論文
著者
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RAKUGI Hiromi
Department of Geriatric Medicine, Osaka University Graduate School of Medicine
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北 徹
Department Of Geriatric Medicine Osaka University Graduate School Of Medicine
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KATSUYA Tomohiro
Department of Clinical Gene Therapy, Osaka University Graduate School of Medicine, Suita
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OGIHARA Toshio
Department of Geriatric Medicine, Osaka University Graduate School of Medicine
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NAKAGAMI Hironori
Division of Gene Therapy Science, Osaka University Graduate School of Medicine
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Takami Yoichi
Department Of Geriatric Medicine And Nephrology Osaka University Graduate School Of Medicine
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KANEDA Yasufumi
Division of Gene Therapy Science, Graduate School of Medicine, Osaka University
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Kawano Yuhei
Division Of Hypertension And Nephrology National Cardiovascular Center
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Kamide Kei
Division Of Hypertension And Nephrology Department Of Medicine National Cardiovascular Center
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Morishita Ryuichi
Division Of Gene Therapy Science Osaka University Graduate School Of Medicine
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HORIO Takeshi
Division of Hypertension and Nephrology, National Cardiovascular Center
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Kawano Yuhei
Division Of Hypertension And Nephrology Department Of Internal Medicine National Cardiovascular Cent
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Rakugi Hiromi
Department Of Geriatric Medicine
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Nakagami Hironori
Division Of Clinical Gene Therapy Osaka University Graduate School Of Medicine
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Ogihara Toshio
Department Of Geriatic Medicine
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Kaneda Yasufumi
Division Of Clinical Gene Therapy Osaka University Graduate School Of Medicine
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KIKUCHI Yasushi
Division of Gene Therapy Science, Graduate School of Medicine, Osaka University
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Miyata Toshiyuki
Division of Hypertension and Nephrology, Department of Medicine, National Cardiovascular Center
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Morishita Ryuichi
Division Of Clinical Gene Therapy
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Kikuchi Yasushi
Division Of Gene Therapy Science Graduate School Of Medicine Osaka University
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Katsuya Tomohiro
Department Of Clinical Gene Therapy Osaka University Graduate School Of Medicine
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Horio Takeshi
Division Of Hypertension And Nephrology
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Kamide Kei
Division Of Cardiovascular Medicine Department Of Medicine Jichi Medical University School Of Medicine
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Takami Yoichi
Department Of Cardiology And Hematology Fukushima Medical University
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Kawano Yuhei
Division of Hypertension and Nephrology, Department of Medicine, National Cardiovascular Center
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Morishita Ryuichi
Division of Clinical Gene Therapy, Graduate School of Medicine, Osaka University
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Takami Yoichi
Department of Geriatric Medicine
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Nakagami Hironori
Division of Gene Therapy Science
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Kaneda Yasufumi
Division of Gene Therapy Science
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Katsuya Tomohiro
Department of Geriatric Medicine
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Ogihara Toshio
Department of Geriatric Medicine
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