Polymorphism of myospryn is associated with left ventricular diastolic dysfunction

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概要

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• BACKGROUND: With aging, left ventricle diastolic dysfunction due to pressure overload is an independent risk factor for morbidity and mortality. Mechanisms by which alterations in stretch-induced mechanotransduction contribute to left ventricular diastolic dysfunction remain unclear. Recently, since novel Z-disc related protein, myospryn, expressed in striated muscle cells, has been reported, we examined the relationship between myospryn polymorphisms and alterations in cardiac function with patients in larger population.METHODS: A total of 743 patients with high blood pressure (defined as systolic blood pressure >140 mmHg and/or systolic blood pressure >90 mmHg or taking antihypertensive medication) were enrolled in this study. Two-dimensional ultrasound echocardiography, electrocardiography, blood pressure, serum glucose, cholesterol, creatinine, uric acid, and myospryn K2906N polymorphism.RESULTS: The myospryn K2906N polymorphism was significantly associated with a marker of left ventricular diastolic cardiac dysfunction, A/E, which represents the ratio of the peak velocity of the early diastolic filling wave (E wave) to the atrial filling (A wave).CONCLUSIONS: These data demonstrated that a polymorphism of myospryn was associated with left ventricular diastolic dysfunction in hypertensive patients and provided the novel therapeutic target for cardiac adaptation in response to pressure overload as an anti-aging therapy.

• 一般社団法人 日本抗加齢医学会の論文

著者

• RAKUGI Hiromi

  Department of Geriatric Medicine, Osaka University Graduate School of Medicine

• 北 徹

  Department Of Geriatric Medicine Osaka University Graduate School Of Medicine

• KATSUYA Tomohiro

  Department of Clinical Gene Therapy, Osaka University Graduate School of Medicine, Suita

• OGIHARA Toshio

  Department of Geriatric Medicine, Osaka University Graduate School of Medicine

• NAKAGAMI Hironori

  Division of Gene Therapy Science, Osaka University Graduate School of Medicine

• Takami Yoichi

  Department Of Geriatric Medicine And Nephrology Osaka University Graduate School Of Medicine

• KANEDA Yasufumi

  Division of Gene Therapy Science, Graduate School of Medicine, Osaka University

• Kawano Yuhei

  Division Of Hypertension And Nephrology National Cardiovascular Center

• Kamide Kei

  Division Of Hypertension And Nephrology Department Of Medicine National Cardiovascular Center

• Morishita Ryuichi

  Division Of Gene Therapy Science Osaka University Graduate School Of Medicine

• HORIO Takeshi

  Division of Hypertension and Nephrology, National Cardiovascular Center

• Kawano Yuhei

  Division Of Hypertension And Nephrology Department Of Internal Medicine National Cardiovascular Cent

• Rakugi Hiromi

  Department Of Geriatric Medicine

• Nakagami Hironori

  Division Of Clinical Gene Therapy Osaka University Graduate School Of Medicine

• Ogihara Toshio

  Department Of Geriatic Medicine

• Kaneda Yasufumi

  Division Of Clinical Gene Therapy Osaka University Graduate School Of Medicine

• KIKUCHI Yasushi

  Division of Gene Therapy Science, Graduate School of Medicine, Osaka University

• Miyata Toshiyuki

  Division of Hypertension and Nephrology, Department of Medicine, National Cardiovascular Center

• Morishita Ryuichi

  Division Of Clinical Gene Therapy

• Kikuchi Yasushi

  Division Of Gene Therapy Science Graduate School Of Medicine Osaka University

• Katsuya Tomohiro

  Department Of Clinical Gene Therapy Osaka University Graduate School Of Medicine

• Horio Takeshi

  Division Of Hypertension And Nephrology

• Kamide Kei

  Division Of Cardiovascular Medicine Department Of Medicine Jichi Medical University School Of Medicine

• Takami Yoichi

  Department Of Cardiology And Hematology Fukushima Medical University

• Kawano Yuhei

  Division of Hypertension and Nephrology, Department of Medicine, National Cardiovascular Center

• Morishita Ryuichi

  Division of Clinical Gene Therapy, Graduate School of Medicine, Osaka University

• Takami Yoichi

  Department of Geriatric Medicine

• Nakagami Hironori

  Division of Gene Therapy Science

• Kaneda Yasufumi

  Division of Gene Therapy Science

• Katsuya Tomohiro

  Department of Geriatric Medicine

• Ogihara Toshio

  Department of Geriatric Medicine

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