N-Acetylcysteine Reduces the Severity of Atherosclerosis in Apolipoprotein E-Deficient Mice by Reducing Superoxide Production
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概要
- 論文の詳細を見る
Background: Oxidative stress may play an important role in the development of atherosclerosis. Because N-acetylcysteine (NAC) is able to reduce oxidative stress, the present study assessed the hypothesis that NAC may reduce the severity of atherosclerosis in apolipoprotein (apo) E-deficient mice. Methods and Results: Atherosclerosis was induced in apoE-deficient mice fed a high-fat diet containing 0.3% cholesterol. Mice were injected intraperitoneally with NAC (20 mg · kg-1 · day-1) 3 times per week over 8 weeks. Fatty streak plaque developed in the apoE-deficient mice, but not in mice treated with NAC. In addition, NAC reduced superoxide production in the aortic walls, as detected by ethidium staining. NAC treatment did not significantly modify the serum lipid profiles. Conclusions: In this animal model NAC may suppress atherosclerosis via reducing superoxide production.
- 社団法人 日本循環器学会の論文
- 2009-06-20
著者
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北 徹
Department Of Geriatric Medicine Osaka University Graduate School Of Medicine
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北 徹
京都大学大学院医学研究科循環器内科学
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SHIMADA Kana
Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University
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MURAYAMA Toshinori
Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University
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YOKODE Masayuki
Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University
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KITA Toru
Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University
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UZUI Hiroyasu
First Department of Internal Medicine, Faculty of Medical Sciences, University of Fukui
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UEDA Takanori
First Department of Internal Medicine, Faculty of Medical Sciences, University of Fukui
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LEE Jong-Dae
First Department of Internal Medicine, Faculty of Medical Sciences, University of Fukui
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KISHIMOTO Chiharu
Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University
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Kita Toru
京都大学 医学研究科循環器内科学
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Kita Toru
Department Of Cardiovascular Medicine Graduate School Of Medicine Kyoto University
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Kita Toru
Department Of Geriatric Medicine Graduate School Of Medicine Kyoto University
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Katsuya Tomohiro
東北大学 臨床薬学
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Lee Jong-dae
京都大学 医学研究科循環器内科学
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Lee Jong-dae
First Department Of Internal Medicine Faculty Of Medical Sciences University Of Fukui
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Kishimoto Chiharu
Department Of Cardiovascular Medicine Graduate School Of Medicine Kyoto University
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Kishimoto Chiharu
Department Of Cardiology Shizuoka Central Prefectural Hospital Shizuoka
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Shimada Kana
Department Of Cardiovascular Medicine Graduate School Of Medicine Kyoto University
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Murayama Toshinori
Department Of Cardiovascular Medicine Graduate School Of Medicine Kyoto University
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Kokuho Toshiharu
横浜市立大学 医学部循環器内科
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Uzui Hiroyasu
京都大学 医学研究科循環器内科学
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Uzui Hiroyasu
First Department Of Internal Medicine Fukui Medical University
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Ueda T
First Department Of Internal Medicine Faculty Of Medical Sciences University Of Fukui
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Ueda Takanori
福井大学医学部附属病院 循環器内科
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Kita Toru
Department Of Cardiology Kobe City Medical Center General Hospital
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Kawamura Tetsuya
東京慈恵会医科大学 腎臓・高血圧内科
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Kawamura T
The Division Of Nephrology And Hypertension
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Kita Toru
National Hospital Organization And Department Of Cardiovascular Medicine Graduate School Of Medicine
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KIMURA Tokihisa
Furukawa City Hospital
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Tanaga Kosei
千葉県循環器病センター 循環器科
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Ueda Takanori
First Department Of Internal Medicine Faculty Of Medical Sciences University Of Fukui
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Uzui Hiroyasu
First Department Of Internal Medicine Faculty Of Medical Sciences University Of Fukui
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Yokode Masayuki
Department Of Cardiovascular Medicine Graduate School Of Medicine Kyoto University
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Lee Jong-dae
Departments Of First Internal Medicine Fukui Medical University
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Tamura Kouichi
Second Department Of Internal Medecine Yokohama City University School Of Medicine
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Kishimoto Chiharu
Third Division Of Internal Medicine Kyoto Univercity Hospital.
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Kawamura Tetsuya
The Division Of Nephrology And Hypertension
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Kuwasako Takahiro
Suita Municipal Hospital
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Kobayashi Toru
Center for Adult Diseases
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Kawamura Tetsuya
Second Department Of Internal Medicine Jikei University School Of Medicine
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Kawamoto Takahiro
Department Of Geriatric Medicine Graduate School Of Medicine Kyoto University
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Kita Toru
Department Of Clinical Bio-regulatory Science Division Of Molecular Medicine For Adult And Geriatric
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Kikkawa Toshiro
Department Of Cardiology National Hospital Organization Kure Medical Center
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Katsuya Tomohiro
The Department Of Geriatric Medicine Osaka University Medical School
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Lewis J
Washington Univ. Medical Center St. Louis Usa
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Yokode Masayuki
Department Of Clinical Bio-regulatory Science Division Of Molecular Medicine For Adult And Geriatric
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Konta Tsuneo
First Department Of Medicine Yamagata University
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Katuya Tomohiro
Department Of Geriatric Medicine Osaka University Graduate School Of Medicine
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Kogure T
Department Of Internal Medicine And Cardiorenal Medicine Yokohama City University Graduate School Of
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Kawamura Tetsuya
Department Of Nephrology And Hypertension School Of Medicine Jikei University
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Kishimoto Chiharu
Department Of Cardiovascular Medicine Guraduate School Of Medicine Kyoto University
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Kobayashi Tatsuya
Department Of Nephrology Saitama Medical College
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Tamura Kouichi
Division Of Kidney And Hypertension Department Of Internal Medicine The Jikei University School Of M
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Konta Tsuneo
Department Of Neurology Hematology Metabolism Endocrinology And Diabetes Yamagata University School
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