Effect of LDL Apheresis on Atherosclerosis Goes beyond Its Cholesterol Lowering in Hemodialysis Patients : A Pilot Study
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概要
- 論文の詳細を見る
The purpose of this pilot study was to investigate clinical effects of LDL apheresis for the treatment of peripheral arterial disease (PAD) in patients on hemodialysis. Eleven patients suffering from PAD were treated with ten sessions of LDL apheresis. Absolute walking distance, ankle brachial blood pressure index (ABI), and laboratory parameters were assessed at baseline, at the tenth session, and three months after the end of the treatment. Patients were assigned to two groups; ABI responders, and ABI non-responders. Absolute walking distance tended to increase in ABI responders at three months after the end of the treatment, but did not increase in ABI non-responders. Although a single LDL apheresis session decreased serum total cholesterol and triglycerides levels in both groups, these effects were not observed at the tenth session. On the other hand, serum levels of LDL cholesterol and fibrinogen tended to remain lower only in ABI responders still at the tenth session. These results suggest that therapeutic benefits of LDL apheresis may depend not only on decreases in serum lipid levels, but also on improvements in other factors, in hemodialysis patients suffering from PAD.
- 日本アフェレシス学会の論文
- 2008-10-31
著者
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北 徹
Department Of Geriatric Medicine Osaka University Graduate School Of Medicine
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Umemura Satoshi
Department of medical science and cardiorenal medcine, Yokohama City University Graduate School of M
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MASUDA Shin-ichiro
Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of
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TAMURA Kouichi
Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of
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WAKUI Hiromichi
Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of
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AZUMA Koichi
Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of
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Shigenaga Atsuichiro
Department of Cardiorenal Medicine, Yokohama City University Graduate School of Medicien
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Ozawa Motoko
Department of Cardiorenal Medicine, Yokohama City University Graduate School of Medicien
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UMEMURA Satoshi
Yokohama City University
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Tsurumi-Ikeya Yuko
Department of Cardiorenal Medicine, Yokohama City University Graduate School of Medicine
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Shigenaga Atsu-ichiro
Department of Cardiorenal Medicine, Yokohama City University Graduate School of Medicine
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Yabana Machiko
Department of Cardiorenal Medicine, Yokohama City University Graduate School of Medicine
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Toya Yoshiyuki
Department of Cardiorenal Medicine, Yokohama City University Graduate School of Medicine
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Ohnishi Toshimasa
Department of Cardiorenal Medicine, Yokohama City University Graduate School of Medicine
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Kita Toru
Department Of Cardiovascular Medicine Graduate School Of Medicine Kyoto University
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Kita Toru
Department Of Geriatric Medicine Graduate School Of Medicine Kyoto University
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Ozawa Motoko
Department Of Medical Science And Cardiorenal Medicine Yokohama City University Graduate School Of M
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Wakui Hiromichi
Department Of Medical Science And Cardiorenal Medicine Yokohama City University Graduate School Of M
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Shigenaga Atsuichiro
Department Of Cardiorenal Medicine Yokohama City University Graduate School Of Medicien
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Masuda Shin-ichiro
Department Of Medical Science And Cardiorenal Medicine Yokohama City University Graduate School Of M
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Tsurumi Yuko
Department Of Cardiorenal Medicine Yokohama City University Graduate School Of Medicine
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Tsurumi-ikeya Yuko
横浜市立大学 医学研究科第2内科学
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Azuma Koichi
Department Of Medical Science And Cardiorenal Medicine Yokohama City University Graduate School Of M
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Toya Yoshiyuki
Department Of Medical Science And Cardiorenal Medicine Yokohama City University School Of Medicine
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Toya Yoshiyuki
横浜市立大学 医学部循環器内科
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Yabana M
Department Of Medical Science And Cardiorenal Medicine Yokohama City University Graduate School Of M
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Yabana Machiko
横浜市立大学 医学部循環器内科
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Yabana Machiko
Second Department Of Internal Medicine Yokohama City University School Of Medicine
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Sigenaga Atsuichiro
Department Of Medical Science And Cardiorenal Medicine Yokohama City University School Of Medicine
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Ohnishi Toshimasa
Department Of Cardiorenal Medicine Yokohama City University Graduate School Of Medicine
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Kokuho Toshiharu
横浜市立大学 医学部循環器内科
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Umemura S
Department Of Internal Medicine And Cardiorenal Medicine Yokohama City University Graduate School Of
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Toya Yoshiyuki
Second Department Of Internal Medicine Yokohama City University School Of Medicine
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Kawamura Tetsuya
東京慈恵会医科大学 腎臓･高血圧内科
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Ozawa Motoko
Department Of Cardiorenal Medicine Yokohama City University Graduate School Of Medicien
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Tanaga Kosei
千葉県循環器病センター 循環器科
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Ohsawa Masato
Department Of Medical Science And Cardiorenal Medicine Yokohama City University Graduate School Of M
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Azuma Koichi
Department Of Cardiorenal Medicine Yokohama City University Graduate School Of Medicien
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Kobayashi Toru
Center for Adult Diseases
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Tsurumi-ikeya Yuko
Department Of Cardiorenal Medicine Yokohama City University Graduate School Of Medicine
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Tamura Kouichi
Department Of Medical Science And Cardiorenal Medicine Yokohama City University Graduate School Of M
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Umemura S
Department Of Second Internal Medicine Yokohama City University School Of Medicine
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Masuda Shin-ichiro
Department Of Medical Science And Cardio-renal Medicine Yokohama City University Graduate School Of
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Umemura Satoshi
Department Of Internal Medicine Ii Yokohama City University School Of Medicine
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Kogure T
Department Of Internal Medicine And Cardiorenal Medicine Yokohama City University Graduate School Of
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Kobayashi Tatsuya
Department Of Nephrology Saitama Medical College
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Konta Tsuneo
Department Of Neurology Hematology Metabolism Endocrinology And Diabetes Yamagata University School
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Uemura Shiro
1st Dept. Of Int. Med. Nara Medical University
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