Effects of MCI-186 (Edaravone), a Novel Free Radical Scavenger, Upon Experimental Atherosclerosis in Apolipoprotein E-Deficient Mice

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Background Recent evidence suggests that oxidative stress may play a role in the development of atherosclerosis. MCI-186 (3-methyl-1-phenyl-1-parazolin-5-one, edaravone) is a novel free radical scavenger, but it remains unclear whether free radical scavengers would be effective for the prevention of the disease. Methods and Results Experimental atherosclerosis was induced in apolipoprotein E-deficient mice fed a highfat diet containing 0.3% cholesterol. Mice were treated with an intraperitoneal injection of either MCI-186 1mg/kg per day or MCI-186 10mg/kg per day on alternate days over 4 weeks. Fatty streak lesion was suppressed by MCI-186 10mg/kg per day administration, but not by mg/kg per day. Immunohistochemical analysis showed that macrophage and CD4^+ T-cell accumulation and oxidative stress overload in the fatty streak lesion were suppressed in mice that received MCI-186 treatment. Conclusions MCI-186 administration suppressed the development of atherosclerosis, associated with reduced expression of both immune-activated cells and oxidative stress in fatty streak plaques.
社団法人日本循環器学会の論文
2006-08-20