Malfunction of Vascular Control in Lifestyle-Related Diseases : Formation of Systemic Hemoglobin-Nitric Oxide Complex (HbNO) From Dietary Nitrite

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概要

• 論文の詳細を見る

• Nitric oxide (NO) has many physiological functions. It is believed to be produced from <sc>L</sc>-arginine by nitric oxide synthase (NOS), and nitrite and nitrate are waste forms of it. By the way, nitrate and nitrite are abundant in vegetables and fruits, especially leafy vegetables and pickled vegetables. Orally-ingested nitrate is changed to nitrite by micro-organelles living in the hypopharynx area, and nitrite is expected to change to NO in the stomach due to its low pH. Indeed, some researchers reported that NO is found in the gastric cavity, although few reports mentioned the physiological meanings of this NO formation. Therefore, we investigated whether the nitrite-derived NO can shift to the circulation and acts like NOS-derived NO does in tissues. We adopted a stable isotope of nitrite (15NO2−) in order to distinguish between the endogenous nitrite and the exogenously administered one and measured HbNO as an index of circulating NO using electron paramagnetic resonance spectroscopy. It appeared that the oral administration of 15N-nitrite formed the Hb15NO in rat blood and decreased the blood pressure of chronic <sc>L</sc>-NAME treated rats. Our findings suggest that the intake of nitrite (or nitrate)-rich foods such as vegetables and fruits would alter the systemic HbNO dynamism, resulting in the improvement of cardiovascular diseases.

• 社団法人 日本薬理学会の論文
• 2004-12-01

著者

• 吉栖 正典

  奈良県立医科大学 薬理学講座

• Tamaki Toshiaki

  Department of Pharmacology, IHBS, the University of TOKUSHIMA Graduate school

• Yoshizumi Masanori

  Department of Pharmacology, Nara Medical University

• IZAWA Yuki

  Department of Pharmacology, The University of Tokushima Graduate School of Medical Sciences

• TSUCHIYA Koichiro

  Department of Pharmacology, The University of Tokushima Graduate School of Medical Sciences

• KANEMATSU Yasuhisa

  Department of Pharmacology, The University of Tokushima Graduate School, Institute of Health Bioscie

• TAKIGUCHI Yoshiharu

  Department of Clinical Pharmacology, Subdivision of Clinical Pharmaceutical Sciences, Institute of H

• OKAMOTO Masumi

  Department of Pharmacology, Institute of Health Biosciences, University of Tokushima Graduate School

• Izawa Ishizawa

  Department Of Pharmacology The Institute Of Health Bioscience The University Of Tokushima Graduate S

• Tamaki T

  Department Of Pharmacology The Institute Of Health Bioscience The University Of Tokushima Graduate S

• Okamoto M

  Department Of Pharmacology The University Of Tokushima School Of Medicine

• Izawa Yuki

  Department Of Pharmacology The Institute Of Health Bioscience The University Of Tokushima Graduate S

• Okamoto Masumi

  Department Of Pharmacology The University Of Tokushima School Of Medicine

• 岡本 麻衣子

  城西大学

• Tamaki Toshiaki

  The Department Of Pharmacology Kagawa Medical School

• Tamaki Toshiaki

  Department Of Pharmacology Kagawa Medical School

• Tsuchiya Koichiro

  Department Of Clinical Pharmacology Institute Of Health Biosciences The University Of Tokushima Grad

• Kanematsu Yasuhisa

  Department Of Pharmacology Institute Of Health Biosciences The University Of Tokushima Graduate Scho

• Yoshizumi Masanori

  Dep. Of Pharmacology Nara Medical Univ. School Of Medicine Jpn

• Izawa Y

  Department Of Applied Chemistry Aichi Institute Of Technology

• Tamaki T

  Department Of Molecular Engineering National Institute Of Materials And Chemical Research

• Kawai Yoshichika

  Dep. Of Pharmacology The Inst. Of Health Bioscience The Univ. Of Tokushima

• Izawa Y

  Department Of Pharmacology The Institute Of Health Bioscience The University Of Tokushima Graduate S

• Takiguchi Yoshiharu

  Department Of Clinical Pharmacology Subdivision Of Clinical Pharmaceutical Sciences Institute Of Hea

• Takiguchi Yoshiharu

  Department Of Clinical Pharmacology Institute Of Health Biosciences The University Of Tokushima Grad

• Yoshizumi Masanori

  Department Of Pharmacology Nara Medical University School Of Medicine

• Yosizumi Masanori

  Department Of Pharmacology The University Of Tokushima School Of Medicine

• Kitaichi T

  Department Of Cardiovascular Surgery The University Of Tokushima Graduate School Of Health Bioscienc

• Kitaichi T

  Department Of Cardiovascular Surgery The University Of Tokushima Graduate School Of Health Bioscienc

• Takeichi Toshiaki

  Department Of Internal Medicine Health Insurance Naruto Hospital

• Yoshizumi M

  Department of Cardiology and Department of Cardiovascular Surgery, Kobe General Hospital

• Tsuchiya Koichiro

  Department Of Cardiovascular Surgery The University Of Tokushima Graduate School Of Health Bioscienc

• Kanematsu Y

  Department of Pharmacology, Institute of Health Biosciences, University of Tokushima Graduate School

• OKAMOTO Masumi

  Department of Mental Health, School of Public Health, The University of Tokyo

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