Effects of an angiotensin I-converting enzyme inhibitor (SA-446) on renal function in dogs.

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概要

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• The effects of an orally active inhibitor of angiotensin-converting enzyme (SA-446) on systemic arterial pressure, renal function and renin release were examined in anesthetized dogs. Intrarenal infusion of the larger dose of SA-446 (0.1 mg/min) caused an increase in RBF, urine flow and renin release and caused a fall in blood pressure. The smaller dose of SA-446 (0.02 mg/min) did not affect the blood pressure, but it increased the urine flow. However, the same dose of SA-446 in combination with probenecid caused a significant fall in blood pressure. The potentiation of SA-446 with probenecid may be explained by the elevation in plasma SA-446 concentration via the inhibition of its tubular secretion by probenecid.

• 公益社団法人 日本薬理学会の論文

著者

• FUJIOKA Shoji

  Department of Pharmacology, Kagawa Medical School

• Tamaki Toshiaki

  Department Of Pharmacology Kagawa Medical School

• Abe Youichi

  Department Of Pharmacology Kagawa Medical University

• Fujioka Shoji

  Department Of Pharmacology Kagawa Medical School:second Department Of Internal Medicine Osaka City U

• Yamamoto Kenjiro

  Department Of Pharmacology Osaka City University Medical School

• Fukui Kiyoshi

  Department Of Biochemistry National Cardiovascular Center Research Institute

• TAKADA Toyokazu

  Department of Pharmacology, Osaka City University Medical School

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