Renin-Angiotensin System in Genetically Hypertensive Mice : THE 13TH CONFERENCE ON THE PATHOGENESIS OF HYPERTENSION
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概要
- 論文の詳細を見る
We investigated the renin-angiotensin system in the genetically hypertensive (HBP), normotensive (NBP) and low blood pressure (LBP) mice developed by G. Schlager, one of the authors. Renin in the plasma, kidney and submaxillary gland was determined by enzymatic assay and by direct radioimmunoassay (DRIA). Trypsinization of mouse plasma was also investigated. PRA and plasma renin content were not significantly different in the different lines, sexes, and generations. Trypsinization of the plasma revealed the presence of inactive renin, as has also been found in humans, hogs, dogs and rats. The proportion of active renin against trypsinized total renin was about 54-77% and was not significant in the different lines, sexes and generations. There was also no significant difference in renal renin content in the various lines, sexes, and generations. However, in the submaxillary gland, renin content and activity were high in male mice, in every line. These data suggest that the renin-angiotensin system may not contribute to the established phase of blood pressure.
- 社団法人日本循環器学会の論文
- 1984-11-20
著者
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IWAO Hiroshi
Department of Pharmacology, Osaka City University School of Medicine
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Iwao H
Departments Of Kagawa Medical School Neurological Surgery Pharmacology
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KIM Shokei
Department of Pharmacology, Osaka City Unitersity Medical School
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Kim Shokei
the Department of Pharmacology, Osaka City University Medical School
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Katsuma Susumu
Department Of Genomic Drug Discovery Science Kyoto University Graduate School Of Pharmaceutical Scie
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YAMAMOTO KENJIRO
Department of Pharmacology, Osaka City University Medical School
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Kim S
大阪市立大学 薬理
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NAKAMURA NORIFUMI
Department of Pharmacology, Osaka City University Medical School
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IKEMOTO FUMIHIKO
Department of Pharmacology, Osaka City University Medical School
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SCHLAGER GUNTHER
Department of Systematics and Ecology, University of Kansas
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Iwao Hiroshi
Department Of Pharmacology Graduate School Of Medicine Osaka City University
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Nakamura Norifumi
Department Of Pharmacology Osaka City University Medical School
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Yamamoto Kenjiro
Department Of Pharmacology Osaka City University Medical School
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Yamamoto Kenjiro
Department Of Pharmacolory Osaka City University Medical School
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Kim Shokei
Department Of Pharmacolgy Osaka City Unversity Medical School
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Nakamura Norifumi
Department Of Oral And Maxillofacial Surgery Field Of Maxillofacial Rehabilitation Kagoshima Univers
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Ikemoto Fumihiko
Development Research Laboratories Banyu Pharmaceutical Co. Ltd.
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Ikemoto Fumihiko
Department Of Pharmacology Osaka City University Medical School
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Ikemoto F
Banyu Pharmaceutical Co. Ltd. Tsukuba Jpn
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Yamamoto Kenjiro
Dept. Of Pharm. Osaka City Univ. Medical School
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Schlager Gunther
Department Of Systematics And Ecology University Of Kansas
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Iwao Hiroshi
Department Of Cardiovascular Medicine Akita University Graduate School Of Medicine
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Kim Shokei
Department Of Internal Medicine And Cardiology Osaka City University Medical School
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Nakamura Norifumi
Department of Biotechnology, Faculty of Engineering, Kansai University
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