Doppler Echocardiographic Assessment and Cardiac Gene Expression Analysis of the Left Ventricle in Myocardial Infarcted Rats

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概要

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• The purpose of this study was to examine cardiac geometry and function by Doppler echocardiography and to analyze mRNA expression of cardiac phenotype and extracellular matrix in myocardial infarcted rats.Doppler echocardiograms and hemodynamics were measured 2 weeks after myocardial infarction(MI).mRNA levels in the non-infracted left vwntricle(LV)and infarct site were measured by Northen blot anlysis.LV internal diastolic dimension was greater in infarcted(MI)than in sham-operated rats(control)(MI 7.2±0.3mm vs control 4.6±0.3mm, p<0.01).The fractional shortening decreased in Mi rats(MI 32±4% vs control 61±3%, p<0.01).Peak early filling velocity increased in MI rats(MI 91±5 cm/sec vs control 72±4 cm/sec, p<0.05), and deceleration rate of the early filling wave was more rapid in rats with MI(MI 25.1±2.8 m/sec^2 vs control 12.4±1.7 m/sec^2, p<0.01).Late filling velocity decreased(MI 16±3 cm/sec vs control 35±6cm/sec, p<0.05), resulting in a marked increase in the ratio of early filling to late filling(MI 7.1±1.2 vs control 2.5±0.4, p<0.01).mRNA levels for β-myosin heavy chain(β-MHC), α-skeletal actin, atrial natriuretic polypeptide(ANP), collagen types I and III, and matrix metalloproteinase 2(MMP-2)in the non-infracted LV increased significantly by 1.8-, 2.4-, 4.7-, 2.6-, 2.1-(all p<0.01)and 1.4-fold(p<0.05), respectively, compared with sham-operated myocardium.In the infarct site, mRNA levels for transforming growth factor(TGF)-β_1, collagen types I and III, and MMP-2 significantly increased by 3.2-, 11.0-, 9.7-, and 6.3-fold(all p<0.01), respectively, compared with sham-operated myocardium.Myocardial infarcted rat was characterized by cavity dilation and marked abnormalities of systolic and diastolic function, accompanied by a shift of myocytes to fetal phenotype and activation of collagen genes in the non-infarcted myocardium.

• 社団法人日本循環器学会の論文
• 1998-05-20

著者

• Yamaguchi Junichi

  Division Of Cardiology Saitama Prefecture Cardiovascular And Respiratory Center

• IWAO Hiroshi

  Department of Pharmacology, Osaka City University School of Medicine

• Shimada Kenei

  大阪掖済会病院 循環器科

• Shimada Kenei

  Department Of Internal Medicine And Cardiology Osaka City University School Of Medicine

• Shimada Kenei

  ベルランド総合病院 循環器内科

• Kim-mitsuyama Shokei

  熊本大学 医学教育部生体機能薬理学

• Kim-mitsuyama Shokei

  大阪市立大学 医学研究科薬理学

• Shimada Kenei

  Department Of Cardivascular Medicine Osaka Ekisaikai Hospital

• Ozaki Takeshi

  Bell land general hospital

• Yoshiyama Minoru

  First Department of Internal Medicine Osaka City University Medical School

• Takeuchi Kazuhide

  First Department of Internal Medicine Osaka City University Medical School

• Yoshikawa Junichi

  First Department of Internal Medicine Osaka City University Medical School

• Takeuchi Kazuhide

  大阪市立大学 医学研究科循環器病態内科学

• Takeuchi Kazuhide

  The First Department Of Internal Medicine Osaka City University Medical School

• Muro Takashi

  Actmce1

• Muro Takashi

  大阪市立大学 医学部循環器病態内科学

• Muro Takashi

  大阪市立大学 医研究 循環器病態内科

• Hirasawa Akira

  京都大学 薬学研究科ゲノム創薬科学

• Sakata Konomi

  Actmce1

• Hanatai Akihisa

  First Department Of Internal Medicine Osaka City Unitersity Medical School

• OMURA Takashi

  First Department of Internal Medicine, Osaka City Unitersity Medical School

• Shimizu Naruhito

  First Department of Internal Medicine, Osaka City University Medical School

• Shokei Kim

  Department of Pharmacology, Osaka City University Medical School

• Katsuma Susumu

  Department Of Genomic Drug Discovery Science Kyoto University Graduate School Of Pharmaceutical Scie

• SHIMIZU Naruhito

  Department of Cardiology, Division of Medical Technologies, Wakakusa Daiichi Hospital

• Shimizu Naruhito

  Ikuwakai Memorial Hospital

• Iwao Hiroshi

  Department Of Pharmacology Graduate School Of Medicine Osaka City University

• Shimizu Naruhito

  Division Of Cardiology Saiseikai Noe Hospital

• Shimizu Naruhito

  Department Of Cardiology Division Of Medical Technologies Wakakusa Daiichi Hospital

• Hanatani Akihisa

  Department Of Internal Medicine And Cardiology Osaka City University Graduate School Of Medicine

• Iwao Hiroshi

  Department Of Cardiovascular Medicine Akita University Graduate School Of Medicine

• OMURA Takashi

  First Department of Internal Medicine Osaka City University Medical School

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