The Effect of Vasopressin V1- and V2-Receptor Antagonists on Hemodynamics in Early and Late Phase After Myocardial Infarction in Rats
スポンサーリンク
概要
- 論文の詳細を見る
This study was designed to access the effect of a nonpeptide vasopressin V1-receptor antagonist, OPC-21268, and a vasopressin V2-receptor antagonist, OPC-31260, on hemodynamics in the early phase and the late phase after myocardial infarction in rats. In the early phase, OPC-21268 (30 mg/kg/day) or OPC-31260 (30 mg/kg/day) was orally administered from day 1 to days 5 after the operation; and hemodynamics were measured at day 5, in the late phase from 10 weeks to 11 weeks and measured at the end of 11 weeks. In the early phase, OPC-21268 reduced the left ventricular end-diastolic pressure (LVEDP) concomitantly with the reduction in systemic blood pressure, but did not change LVEDP in the late phase. OPC-31260 reduced LVEDP and central venous pressure in both phases. OPC-21268 improved hemodynamics only in the early phase and OPC-31260 improved it in both phases.
- 1998-10-01
著者
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Iwao H
Department Of Pharmacology Osaka City University Medical School
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Yamaguchi Junichi
Division Of Cardiology Saitama Prefecture Cardiovascular And Respiratory Center
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IWAO Hiroshi
Department of Pharmacology, Osaka City University School of Medicine
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Ozaki Takeshi
Bell land general hospital
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Yamagishi Hiroyuki
First Department of Internal Medicine Osaka City University Medical School
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Yoshiyama Minoru
First Department of Internal Medicine Osaka City University Medical School
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Yoshikawa Junichi
First Department of Internal Medicine Osaka City University Medical School
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Sato Hiroshi
大阪大学 医学系研究科循環器内科学
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Takeuchi Kazuhide
大阪市立大学 医学研究科循環器病態内科学
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Takeuchi Kazuhide
The First Department Of Internal Medicine Osaka City University Medical School
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Muro Takashi
Actmce1
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Muro Takashi
大阪市立大学 医学部循環器病態内科学
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Muro Takashi
大阪市立大学 医研究 循環器病態内科
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OMURA Takashi
First Department of Internal Medicine, Osaka City Unitersity Medical School
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Fujita Hisayoshi
Department of Internal Medicine and Cardiology, Graduate School of Medicine, Osaka City University
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Fujita Hisayoshi
Department Of Internal Medicine And Cardiology Graduate School Of Medicine Osaka City University
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FUJITA Hisayoshi
First Department of Internal Medicine, Osaka City University Medical School
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TAKEUCHI Kazuhide
1First Department of Internal Medicine, Osaka City University Medical School
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MIURA Katuyuki
Department of Pharmacology, Osaka City University Medical School
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Iwao Hiroshi
Department Of Pharmacology Graduate School Of Medicine Osaka City University
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Yamashita Hajime
Department Of Internal Medicine And Cardiology Osaka City University Graduate School Of Medicine
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Miura Katuyuki
Department Of Pharmacology Osaka City University Medical School
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Iwao Hiroshi
Department Of Cardiovascular Medicine Akita University Graduate School Of Medicine
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OMURA Takashi
First Department of Internal Medicine Osaka City University Medical School
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