Non-Invasive Assessment of Plaque Rupture by 64-Slice Multidetector Computed Tomography : Comparison With Intravascular Ultrasound

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概要

• 論文の詳細を見る

• Background Plaque rupture and secondary thrombus formation play key roles in the onset of acute coronary syndrome (ACS). Multidetector computed tomography (MDCT) allows the non-invasive assessment of coronary artery stenosis and plaque properties. In this study, we investigated whether 64-slice MDCT could non-invasively detect a plaque rupture in patients with de novo angina. Methods and Results The study population comprised 67 patients with de novo angina. All patients underwent contrast-enhanced 64-slice MDCT and intravascular ultrasound (IVUS). Patients were divided into a plaque rupture group (n=27) and a non-rupture group (n=40) based on the IVUS. The 64-slice MDCT revealed that the prevalence of an ulcer-like enhancement space (37% vs 5%, p<0.01), a ring-like sign (41% vs 18%, p=0.04), in the plaque rupture group was higher than those in the non-rupture group. Maximum plaque thickness (2.1± 0.9mm vs 1.6±1.0mm, p=0.04), outer vessel area (17.6±4.9mm^2 vs 13.4±5.0mm^2, p<0.01), percentage plaque area (82.3±9.1% vs 73.4±15.7%, p=0.01), and remodeling index (1.11±0.18 vs 1.01±0.15, p=0.04) of the plaque rupture group were all significantly larger than those of the non-rupture group. Conclusions The 64-slice MDCT can identify differences in lesion morphologies between ruptured plaques and non-ruptured plaques. From our results, the 64-slice MDCT might provide a useful tool for the non-invasive detection of plaque rupture.

• 社団法人日本循環器学会の論文
• 2008-07-20

著者

• IMANISHI Toshio

  Department of Cardiovascular Medicine, Wakayama Medical University

• Yoshida Kaoru

  Department Of Cardiology Kawasaki Medical School

• Yoshikawa J

  Department Of Medicine Cardiovascular Division Osaka Ekisaikai Hospital

• Akasaka Takashi

  Department Of Cardiovascular Medicine Tohoku University Graduate School Of Medicine

• Yamaguchi Junichi

  Division Of Cardiology Saitama Prefecture Cardiovascular And Respiratory Center

• Matsuba Kunio

  Department Of Medicine Cardiovascular Division Osaka Ekisaikai Hospital

• Shimada Kenei

  Osaka Ekisaikai Hospital

• Shimada Kenei

  Department Of Internal Medicine And Cardiology Osaka City University School Of Medicine

• Shimada Kenei

  Department Of Cardiology Osaka City General Hospital

• Jissho Satoshi

  Department Of Medicine Cardiovascular Division Osaka Ekisaikai Hospital

• Shimada Kenei

  ベルランド総合病院 循環器内科

• Yoshikawa Junichi

  大阪掖済会病院 循環器科

• Yoshida Ken

  Osaka Ekisaikai Hospital

• Yoshikawa Junichi

  Osaka Ekisaikai Hospital

• Shimada Kenei

  Department Of Medicine Cardiovascular Division Osaka Ekisaikai Hospital

• Shimada Kenei

  Department Of Cardivascular Medicine Osaka Ekisaikai Hospital

• Hasegawa T

  Department Of Cardiology Osaka City University Graduate School Of Medicine

• Tanaka Atsushi

  Wakayama Medical University

• Jissyo Satoshi

  Osaka Ekisaikai Hospital

• Tanaka Hidemasa

  Osaka Ekisaikai Hospital

• Sakamoto Makoto

  Osaka Ekisaikai Hospital

• Matsuba Kunio

  Osaka Ekisaikai Hospital

• Imanishi Toshio

  Wakayama Medical University

• Akasaka Takashi

  Wakayama Medical University

• Yamaguchi Junichi

  Kanto Medical Center NTT-EC

• Shimeno Kenji

  Department Of Internal Medicine And Cardiology Osaka City University Graduate School Of Medicine

• Yoshida Kiyoshi

  Division Of Cardiology Kawasaki Medical School

• Imanishi Toshio

  Department Of Cardiovascular Medicine Wakayama Medical University

• Asahara Takayuki

  先端医療振興財団先端医療センター 血管再生研究グループ

• Sakata Konomi

  Actmce1

• Hasegawa Takao

  Department Of Internal Medicine And Cardiology Osaka Ekisaikai Hospital

• Yoshida Kiyoshi

  Kawasaki Medical University

• Hasegawa Takao

  Internal Medicine And Cardiology Osaka City University

• Akasaka Takashi

  Department Of Cardiovascular Medicine Wakayama Medical University

• Shiratori Kenichi

  Juntendo University Shizuoka Hospital

• Yoshikawa Junichi

  Osaka City University Graduate School Of Medicine

• Takaki Aya

  Department Of Cardiovascular Medicine Tohoku University Graduate School Of Medicine

• Yamaguchi Junichi

  NTT East Japan Kanto Hospital

• KAWASHIMA YASUNARI

  FIRST DEPARTMENT OF SURGERY OSAKA UNIVERSITY MEDICAL SCHOOL

• Yoshioka Kunihiro

  Department Of Cardiovascular Science And Medicine Chiba University Graduate School Of Medicine

• Yoshikawa Junichi

  Department Of Pediatric Cardiology And Cardialogy Kobe General Hospital

• Asahara Takayuki

  Department Of Cardiovascular Medicine Wakayama Medical University

• Tanaka Hidemasa

  Osaka City Univ.

• Akasaka Takashi

  Divison Of Regenerative Medicine

• Yoshikawa Junichi

  Department Of Cardiovascular Medicine Osaka City University Graduated School Of Medicine

• Akasaka Takashi

  Department Of Cardiology Wakayama Medical University

• Kobayashi Yoshiki

  Department Of Internal Medicine Osaka City General Hospital

• Kim Shokei

  Department Of Pharmacology Osaka City University Graduate School Of Medicine

• Asahara Takayuki

  Department Of Medicine St.elizabeth's Medical Center Tufts University School Of Medicine

• Shimamura Kunihiro

  Department Of Cardiovascular Medicine Wakayama Medical University

• Yoshioka Kunihiro

  Actmce1 Trial Investigators

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