Nicorandil Treatment in Patients With Acute Myocardial Infarction : A Meta-Analysis

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概要

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• Background: It is controversial as to whether nicorandil would have cardioprotective effects in patients with acute myocardial infarction (AMI) who are undergoing reperfusion therapy. A meta-analysis was performed to study the impacts of nicorandil on functional outcomes after AMI. Methods and Results: Randomized prospective cohort or retrospective cohort publications were identified up to October 2007 by means of a computer search of MEDLINE and Google Scholar databases. Two reviewers checked the quality of the studies and extracted data regarding patient and disease characteristics, study design, functional parameters such as Thrombolysis In Myocardial Infarction (TIMI) flow grade after reperfusion, left ventricular ejection fraction (LVEF) and left ventricular end-diastolic volume index (LVEDVI). Seventeen studies were included for the meta-analysis in this study. Nicorandil treatment reduced the incidence of TIMI flow grade ≤2 in 1,337 patients of 10 studies (risk ratio 0.63; 95% confidence interval (CI) 0.44 to 0.91). While no beneficial effect was observed on the peak creatine kinase value, nicorandil treatment was associated with greater LVEF (by 3.7%, 95%CI 1.8 to 5.7%), and lower LVEDVI (by 8.8 ml/kg, -14.4 to -3.3 ml/kg) in 905 patients of 11 studies. Conclusions: The meta-analysis demonstrated that nicorandil treatment adjunctive to reperfusion therapy has beneficial effects on microvascular function and on functional recovery after AMI.

• 社団法人　日本循環器学会の論文
• 2009-04-20

著者

• ITO Hiroshi

  Sakurabashi Watanabe Hospital

• Imai Katsuji

  Cardiovascular Center Sakurabashi Watanabe Hospital

• Inoue Koichi

  Cardiovascular Center Sakurabashi Watanabe Hospital

• Inoue Katsumi

  松江赤十字病院 循環器科

• Koyama Yasushi

  Cardiovascular Center Sakurabashi Watanabe Hospital

• IWAKURA Katsuomi

  Cardiovascular Center, Sakurabashi Watanabe Hospital

• ITO Hiroshi

  Cardiovascular Center, Sakurabashi Watanabe Hospital

• OKAMURA Atsushi

  Cardiovascular Center, Sakurabashi Watanabe Hospital

• DATE Motoo

  Cardiovascular Center, Sakurabashi Watanabe Hospital

• HIGUCHI Yoshiharu

  Cardiovascular Center, Sakurabashi Watanabe Hospital

• KIMURA Ryusuke

  Cardiovascular Center, Sakurabashi Watanabe Hospital

• NAGAI Hiroyuki

  Cardiovascular Center, Sakurabashi Watanabe Hospital

• IMAI Michio

  Cardiovascular Center, Sakurabashi Watanabe Hospital

• TOYOSHIMA Yuko

  Cardiovascular Center, Sakurabashi Watanabe Hospital

• OZAWA Makito

  Cardiovascular Center, Sakurabashi Watanabe Hospital

• ITO Norihisa

  Cardiovascular Center, Sakurabashi Watanabe Hospital

• OKAZAKI Yukinori

  Cardiovascular Center, Sakurabashi Watanabe Hospital

• SHIBUYA Masahiko

  Cardiovascular Center, Sakurabashi Watanabe Hospital

• SUENAGA Hideaki

  Cardiovascular Center, Sakurabashi Watanabe Hospital

• KUBOTA Asuka

  Cardiovascular Center, Sakurabashi Watanabe Hospital

• FUJII Kenshi

  Cardiovascular Center, Sakurabashi Watanabe Hospital

• Date Motoo

  Division of Cardiology, Sakurabashi Watanabe Hospital

• Nagai Hiroyuki

  Division of Cardiology, Sakurabashi Watanabe Hospital

• Imai Michio

  Division of Cardiology, Sakurabashi Watanabe Hospital

• Itoh Norihisa

  Division of Cardiology, Sakurabashi Watanabe Hospital

• Okazaki Yukinori

  Division of Cardiology, Sakurabashi Watanabe Hospital

• Shibuya Masahiko

  Division of Cardiology, Sakurabashi Watanabe Hospital

• Inoue Hiroko

  Division Of Cardiology Sakurabashi Watanabe Hospital

• Iwakura K

  Cardiovascular Center Sakurabashi Watanabe Hospital

• Ito Hisao

  Department Of Radiology Graduate School Of Medicine Chiba University

• Iwao H

  Department Of Pharmacology Osaka City University Medical School

• Iwao Hiroshi

  Sakurabashi Watanabe Hospital

• Inanami Hitoshi

  大阪掖済会病院 循環器

• Iwao Hiroshi

  大阪市立大学 医学部薬理学

• Iwao Hiroshi

  大阪市立大学 医学部薬効安全性学

• Ito Hiroshi

  秋田大学 医学部循環器内科学

• Iwakura Katsuomi

  桜橋渡辺病院 心臓血管センター

• Iwakura Katsuomi

  Cardiovascular Center Sakurabashi Watanabe Hospital

• Kubota Asuka

  Cardiovascular Center Sakurabashi Watanabe Hospital

• Suenaga Hidetaka

  Cardiovascular Center Sakurabashi Watanabe Hospital

• Sato Hiroshi

  Department Of Pharmacology Osaka City University Medical School

• Sato Hiroshi

  大阪大学 医学系研究科循環器内科学

• Iwao Hiroshi

  大阪市立大学 医分子生体医学

• Inoue Katsumi

  Sakurabashi Watanabe Hospital

• Ohsawa Masahiko

  Sakurabashi Watanabe Hospital

• Higuchi Yoshiharu

  Division Of Cardiology Sakurabashi Watanabe Hospital

• Date Motoo

  Division Of Cardiology Sakurabashi Watanabe Hospital

• Imai Michio

  Division Of Cardiology Sakurabashi Watanabe Hospital

• Fujii Kenshi

  Division Of Cardiology Sakurabashi Watanabe Hospital

• Fujii Kenji

  The Division Of Cardiology Sakurabashi Watanabe Hospital

• Ozawa Makito

  Division Of Cardiology Sakurabashi Watanabe Hospital

• Itoh Norihisa

  Division Of Cardiology Sakurabashi Watanabe Hospital

• Ishii Hideshi

  大阪市立大学 循環器病態内科学

• Toyoshima Yuko

  Division Of Cardiology Sakurabashi Watanabe Hospital

• Nagai Hiroyuki

  Division Of Cardiology Sakurabashi Watanabe Hospital

• Kimura Ryusuke

  Division Of Cardiology Sakurabashi Watanabe Hospital

• Fujii Kenshi

  The First Department Of Medicine Osaka University School Of Medicine

• Fujimoto Kouhei

  Department Of Internal Medicine And Cardiology Graduate School Of Medicine Osaka City University

• Ozawa Makito

  Cardiovascular Center Sakurabashi Watanabe Hospital

• Iwai K

  Osaka Univ. Osaka Jpn

• Okazaki Yukinori

  Division Of Cardiology Sakurabashi Watanabe Hospital

• Itagane Hiroshi

  Department Of Cardiology Osaka City General Hospital

• Okamura Atsunori

  Division Of Cardiology Sakurabashi Watanabe Hospital

• Kajiya Fumihoko

  Dept. Of Electronics Faculty Of Eng. Osaka Univ.

• Fujii Kenji

  The First Department Of Medicine Osaka University Medical School

• Iwai Kunimitsu

  The First Department Of Medicine Osaka University Medical School

• Shibuya Masahiko

  Division Of Cardiology Sakurabashi Watanabe Hospital

• Iida Hidetaka

  Department Of Radiology Graduate School Of Medicine Chiba University

• Fujimoto Kouhei

  Division Of Cardiology Sakurabashi Watanabe Hospital

• Itou Hisao

  Department Of Radiology School Of Medicine Chiba University

• Iwao Hiroshi

  Department Of Pharmacology Osaka City University Graduate School Of Medical Science

• Fujii Kenshi

  桜橋渡辺病院

• Kajiya Fumihiko

  Dept. Of Electronic Engineering Osaka Univ. Schoot Of Facul. Of Engineering

• Kimura Ryusuke

  Cardiovascular Center Sakurabashi Watanabe Hospital

• Toyoshima Yuko

  Cardiovascular Center Sakurabashi Watanabe Hospital

• Fujii Kenshi

  Cardiovascular Center Sakurabashi Watanabe Hospital

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• OE-036 Residual Non-pulmonary Vein arrhthmogenic Foci Predict the Recurrence of Tachyarrhythmia in Patients with Atrial Fibrillation Undergoing Catheter Ablation(Arrhythmia, diagnosis/Pathophysiology/EPS(01)(A),Oral Presentation(English),The 72nd Annual S
• OE-035 Pre-existent Elevated CRP is Associated with the Recurrence of Atrial Tachyarrhythmia after Catheter Ablation in Patients with Atrial Fibrillation(Arrhythmia, diagnosis/Pathophysiology/EPS(01)(A),Oral Presentation(English),The 72nd Annual Scientifi

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