Effects of Prolonged Treatment with β-Adrenoceptor Antagonist, Carteolol on Systemic and Regional Hemodynamics in Stroke-Prone Spontaneously Hypertensive Rats

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概要

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• The present study was designed to determine the regional hemodynamic effects of prolonged β-adrenergic receptor inhibition in conscious stroke-prone spontaneously hypertensive rats (SHRSP) using a radioactive microsphere method. When the regional blood flow was compared between 10 and 30 weeks of age, the age-related changes in organ blood flow were observed in several organs, i.e., the reduction of flow rate in kidney, adrenal gland and intestines. The reduction of flow rate in these organs contributes strongly to the age-related rise of total peripheral resistance. Carteolol, a β-adrenoceptor antagonist, was given at a dose of 10 mg/kg/d from 10 to 30 weeks of age. These animals gained more weight than the untreated control SHRSPs, and heart rate was reduced significantly. Blood pressure was not affected. However, the prolonged treatment with carteolol prevented the age-related reduction of the blood flow rate in the kidney, adrenal gland and intestines. Thus, our findings indicate that carteolol had appreciable and beneficial effects on the maintenance of flow rates in the above organs of SHRSP without any change in blood pressure.

• 公益社団法人日本薬学会の論文

著者

• IWAO Hiroshi

  Department of Pharmacology, Osaka City University School of Medicine

• Tamaki Toshiaki

  Department of Pharmacology, IHBS, the University of TOKUSHIMA Graduate school

• ABE Youichi

  Department of Pharmacology, Kagawa University Medical School

• Iwao H

  Departments Of Kagawa Medical School Neurological Surgery Pharmacology

• OHMOTO Takashi

  Department of Neurological Surgery,Okayama University Medical School

• Fukui Kiyoshi

  Departments Of Kagawa Medical School Neurological Surgery Pharmacology

• Ohmoto Takashi

  Department Of Neurological Surgery Okayama University Medical School

• Ohmoto Takashi

  Departments Of Kagawa Medical School Neurological Surgery Pharmacology

• Tamaki Toshiaki

  The Department Of Pharmacology Kagawa Medical School

• Tamaki Toshiaki

  Department Of Pharmacology Kagawa Medical School

• Iwao Hiroshi

  Department Of Pharmacology Graduate School Of Medicine Osaka City University

• Youichi Abe

  Department Of Pharmacology Kagawa University Medical School

• Abe Youichi

  Department Of Pharmacology Kagawa Medical University

• Abe Youichi

  Departments Of Kagawa Medical School Neurological Surgery Pharmacology

• Iwao H

  Osaka City Univ. Medical School Osaka Jpn

• HASUI Kouichi

  Departments of Kagawa Medical School Neurological Surgery Pharmacology

• Fukui Kiyoshi

  Department Of Biochemistry National Cardiovascular Center Research Institute

• Ohmoto Takashi

  Department Of Neurological Surgery Kagawa Medical School

• Iwao Hiroshi

  Department Of Cardiovascular Medicine Akita University Graduate School Of Medicine

• OHMOTO Takashi

  Department of Environmental Technology, Osaka Municipal Technical Research Institute

• HASUI Kouichi

  Department of Pharmacology, Kagawa Medical School

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