Effects of an Antihypertensive Vasodilator, Pinacidil, on Regional Blood Flow in Conscious Spontaneously Hypertensive Rats

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概要

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• Using a radioactive microsphere method, the effects of hydralazine and a new antihypertensive vasodilator, pinacidil, on systemic and regional hemodynamics were examined and compared in conscious Wistar Kyoto rats (WKY) and spontaneously hypertensive rats (SHR). A single intravenous administration of pinacidil decreased mean blood pressure in a dose dependent fashion (0.03-0.3mg/kg), and the peak effect was observed within a few minutes after administration. The onset of the hypotensive action of hydralazine was relatively slow compared to that of pinacidil, and its peak effect appeared 5-10 min after administration. There was no difference between WKY and SHR in the time course of blood pressure change, but the pressure reduction in WKY was less than that in SHR. We observed regional hemodynamic differences between the normotensive rats and the hypertensive rats. The flow rates in the kidney, spleen, gastrointestinal tract and skin of SHR were significantly lower than those of WKY. The intravenous infusion of pinacidil at a rate of 0.06 mg/kg/min increased cardiac output and heart rate, and selectively increased flow rates in organs with low flow rates compared to normotensive controls except for the spleen. Thus, pinacidil reduced total peripheral resistance of SHR to levels of WKY and normalized hemodynamic abnormalities in SHR. The regional hemodynamic action of pinacidil in SHR was not qualitatively different from that of hydralazine except in a few organs.

• 公益社団法人日本薬学会の論文

著者

• IWAO Hiroshi

  Department of Pharmacology, Osaka City University School of Medicine

• Tamaki Toshiaki

  Department of Pharmacology, IHBS, the University of TOKUSHIMA Graduate school

• 木村 正司

  Department Of Pharmacology Kagawa Medical University

• KIMURA Shoji

  Department of Pharmacology, Kagawa University Medical School

• ABE Youichi

  Department of Pharmacology, Kagawa University Medical School

• 木村 正司

  香川医大・薬理

• Iwao H

  Departments Of Kagawa Medical School Neurological Surgery Pharmacology

• Kagami Shoji

  Department Of Pediatrics The University Of Tokushima Graduate School Of Medical Sciences

• Fukui Kiyoshi

  Departments Of Kagawa Medical School Neurological Surgery Pharmacology

• FUJIOKA Shoji

  Department of Pharmacology, Kagawa Medical School

• Tamaki Toshiaki

  The Department Of Pharmacology Kagawa Medical School

• Tamaki Toshiaki

  Department Of Pharmacology Kagawa Medical School

• Iwao Hiroshi

  Department Of Pharmacology Graduate School Of Medicine Osaka City University

• Kimura Shoji

  Department Of Agricultural Chemistry Faculty Of Agriculture Utsunomiya University

• Youichi Abe

  Department Of Pharmacology Kagawa University Medical School

• Abe Youichi

  Department Of Pharmacology Kagawa Medical University

• Abe Youichi

  Departments Of Kagawa Medical School Neurological Surgery Pharmacology

• Fujioka Shoji

  Department Of Pharmacology Kagawa Medical School:second Department Of Internal Medicine Osaka City U

• Iwao H

  Osaka City Univ. Medical School Osaka Jpn

• Kimura S

  The Department Of Pharmacology Kagawa Medical School

• Fukui Kiyoshi

  Department Of Biochemistry National Cardiovascular Center Research Institute

• Iwao Hiroshi

  Department Of Cardiovascular Medicine Akita University Graduate School Of Medicine

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