Electron Paramagnetic Resonance Study on Free Radical Scavenging and/or Generating Activity of Dopamine-4-O-sulfate

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概要

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• The free radical scavenging and/or generating activity of dopamine-4-O-sulfate was examined and compared with that of dopamine. In humans, dopamine mostly exists in two isomeric forms of sulfate ester conjugates as metabolites ; i.e., dopamine-3-O-sulfate and dopamine-4-O-sulfate in the circulation. Dopamine is generally believed to be oxidized by molecular oxygen or another reactive oxygen species under physiological conditions, to form oxidized dopamine derivatives that are cytotoxic. However, it is not known whether dopamine conjugates are generated on interaction with reactive oxygen species or not. In the present study, we measured the susceptibility to oxidization of dopamine-4-O-sulfate by using electron paramagnetic resonance(EPR)spectroscopy and optical absorption spectrometry. Dopamine was easily oxidized and dopamine-derived radicals appeared, whereas dopamine-4-O-sulfate was not oxidized under physiological conditions. Furthermore, dopamine-4-O-sulfate did not react with a strong oxidizing agent, sodium periodate. These results suggest that dopamine-4-O-sulfate has resistance against autoxidation, and seems to be a stable metabolite of dopamine.

• 公益社団法人日本薬学会の論文
• 2001-05-01

著者

• 吉栖 正典

  奈良県立医科大学 薬理学講座

• Tamaki Toshiaki

  Department of Pharmacology, IHBS, the University of TOKUSHIMA Graduate school

• Yoshizumi Masanori

  Department of Pharmacology, Nara Medical University

• TSUCHIYA Koichiro

  Department of Pharmacology, The University of Tokushima Graduate School of Medical Sciences

• HOUCHI Hitoshi

  Department of Pharmacy, the University of Tokushima School of Medicine

• KIRIMA Kazuyoshi

  Department of Pharmacology, The University of Tokushima School of Medicine

• Tamaki T

  Department Of Pharmacology The Institute Of Health Bioscience The University Of Tokushima Graduate S

• Houchi H

  Univ. Tokushima School Of Medicine Tokushima Jpn

• Houchi Hitoshi

  Dep. Of Pharmacy Kagawa Univ. Hospital

• Houchi Hitoshi

  Department Of Pharmacy The University Of Tokushima School Of Medicine

• Houchi Hitoshi

  Department Of Pharmacology The University Of Tokushima School Of Medicine

• Houchi Hitoshi

  Department Of Pharmacology Tokushima University School Of Medicine

• Houchi Hitoshi

  Departments Of Pharmacology The University Of Tokushima School Of Medicine

• Tamaki Toshiaki

  Department Of Pharmacology Kagawa Medical School

• Kirima Kazuyoshi

  Department Of Clinical Pharmacy The Institute Of Health Bioscience The University Of Tokushima Gradu

• Tsuchiya Koichiro

  Department Of Clinical Pharmacology Institute Of Health Biosciences The University Of Tokushima Grad

• Yoshizumi Masanori

  Dep. Of Pharmacology Nara Medical Univ. School Of Medicine Jpn

• Azuma M

  Department Of Applied Chemistry And Bioengineering Graduate School Of Engineering Osaka City Univers

• Tamaki T

  Department Of Molecular Engineering National Institute Of Materials And Chemical Research

• KAMEDA Taisuke

  Department of Pharmacology, The University of Tokushima School of Medicine

• AZUMA Mami

  Department of Pharmacy, The University of Tokushima School of Medicine

• Azuma M

  Univ. Tokushima School Of Medicine Tokushima Jpn

• Kameda Taisuke

  Department Of Pharmacology The University Of Tokushima School Of Medicine

• Yoshizumi Masanori

  Department Of Pharmacology Nara Medical University School Of Medicine

• Yosizumi Masanori

  Department Of Pharmacology The University Of Tokushima School Of Medicine

• Kitaichi T

  Department Of Cardiovascular Surgery The University Of Tokushima Graduate School Of Health Bioscienc

• Takeichi Toshiaki

  Department Of Internal Medicine Health Insurance Naruto Hospital

• Kameda T

  Department Of Civil Engineering Kitami Institute Of Technology

• Tsuchiya Koichiro

  Department Of Cardiovascular Surgery The University Of Tokushima Graduate School Of Health Bioscienc

• Hitoshi H

  Department of Pharmacy, The University of Tokushima School of Medicine

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