Pharmacology in Health Food:Metabolism of Quercetin In Vivo and Its Protective Effect Against Arteriosclerosis

スポンサーリンク

概要

• 論文の詳細を見る

• Quercetin, a member of the bioflavonoids family, has been proposed to have anti-atherogenic, anti-inflammatory, and anti-hypertensive properties leading to the beneficial effects against cardiovascular diseases. It was recently demonstrated that quercetin 3-O-β-D-glucuronide (Q3GA) is one of the major quercetin conjugates in human plasma, in which the aglycone could not be detected. Although most of the in vitro pharmacological studies have been carried out using only the quercetin aglycone form, experiments using Q3GA would be important to discover the preventive mechanisms of cardiovascular diseases by quercetin in vivo. Therefore we examined the effects of the chemically synthesized Q3GA, as an in vivo form, on vascular smooth muscle cell (VSMC) disorders related to the progression of arteriosclerosis. Platelet-derived growth factor–induced cell migration and proliferation were inhibited by Q3GA in VSMCs. Q3GA attenuated angiotensin II–induced VSMC hypertrophy via its inhibitory effect on JNK and the AP-1 signaling pathway. Q3GA scavenged 1,1-diphenyl-2-picrylhydrazyl radical measured by the electron paramagnetic resonance method. In addition, immunohistochemical studies with monoclonal antibody 14A2 targeting the Q3GA demonstrated that the positive staining specifically accumulates in human atherosclerotic lesions, but not in the normal aorta. These findings suggest Q3GA would be an active metabolite of quercetin in plasma and may have preventative effects on arteriosclerosis relevant to VSMC disorders.

• 社団法人 日本薬理学会の論文

著者

• 吉栖 正典

  奈良県立医科大学 薬理学講座

• Tomita Shuhei

  Department Of Pharmacology The Institute Of Health Bioscience The University Of Tokushima Graduate S

• Tamaki Toshiaki

  Department of Pharmacology, IHBS, the University of TOKUSHIMA Graduate school

• Yoshizumi Masanori

  Department of Pharmacology, Nara Medical University

• ISHIZAWA Keisuke

  Department of Pharmacology, The University of Tokushima Graduate School of Medical Sciences

• TSUCHIYA Koichiro

  Department of Pharmacology, The University of Tokushima Graduate School of Medical Sciences

• Minakuchi Kazuo

  Department Of Radiology Osaka Prefectural Medical Center For Respiratory And Allergic Diseases

• Ikeda Yasumasa

  Department of Medicine and Bioregulatory Sciences, The University of Tokushima Graduate School of He

• Ikeda Yasumasa

  Department Of Cardiology Tokushima Prefectural Central Hospital

• KAWAI Yoshichika

  Departments of Food Science, Institute of Health Biosciences, The University of Tokushima Graduate S

• TERAO Junji

  Departments of Food Science, Institute of Health Biosciences, The University of Tokushima Graduate S

• Kihira Yoshitaka

  Department of Pharmacology, The Institute of Health Bioscience, The University of Tokushima

• Minakuchi Kazuo

  Department Of Clinical Pharmacy Institute Of Health Biosciences The University Of Tokushima Graduate

• Tamaki Toshiaki

  Department Of Pharmacology Kagawa Medical School

• Ishizawa Keisuke

  Department Of Pharmacology The Institute Of Health Bioscience The University Of Tokushima Graduate S

• Ishizawa Keisuke

  Department Of Neurology Neurological Institute Tokyo Women's Medical College

• Tsuchiya Koichiro

  Department Of Clinical Pharmacology Institute Of Health Biosciences The University Of Tokushima Grad

• Kanematsu Yasuhisa

  Department Of Pharmacology Institute Of Health Biosciences The University Of Tokushima Graduate Scho

• Yoshizumi Masanori

  Dep. Of Pharmacology Nara Medical Univ. School Of Medicine Jpn

• Kawai Yoshichika

  Department Of Food Science Institute Of Health Biosciences The University Of Tokushima Graduate Scho

• Kawai Yoshichika

  Dep. Of Pharmacology The Inst. Of Health Bioscience The Univ. Of Tokushima

• Terao Junji

  Department Of Food Science Graduate School Of Nutrition And Bioscience The University Of Tokushima

• Yoshizumi Masanori

  Department Of Pharmacology Nara Medical University School Of Medicine

• Kihira Yoshitaka

  Department Of Neural And Pain Sciences Program In Neuroscience University Of Maryland:faculty Of Pha

• Kawai Yoshichika

  Department Of Food Science Graduate School Of Nutrition And Biosciences The University Of Tokushima

• Ishizawa Keisuke

  Department Of Medical Pharmacology Institute Of Health Biosciences The University Of Tokushima Gradu

関連論文

• Olmesartan Inhibits Angiotensin II–Induced Migration of Vascular Smooth Muscle Cells Through Src and Mitogen-Activated Protein Kinase Pathways
• 動脈硬化性疾患における血中遊離型および硫酸抱合カテコールアミンレベル : 閉塞性動脈硬化症と動脈瘤症例での検討
• クリアランスからみた小児開心術後におけるドーパミン投与量の検討
• 47)Angiotensin IIによる成熟ラット単離心筋細胞からのCa^流出機構について
• イヌ開心術モデルにおける核酸成分注射液(OG-VI)の心筋保護効果の検討
• 先天性心疾患に関連して, 外科から小児科へ : 新生児期, 乳児期早期心臓手術症例を中心に : 最近の循環器病の診療の連繋;内科から外科へ, 外科から内科への希望
• PP3-004 腎虚血再灌流時のNO2-由来NO産生経路(一般演題(ポスター))
• 亜硝酸と一酸化窒素(NO)
• 酸化ストレスによる神経細胞死に対するEbselenの抑制効果 : JNK/c-Jun情報伝達系の阻害作用
• P-20 ロサルタンと運動療法のインスリン抵抗性に対する効果 : インスリン抵抗性モデルラットを用いての検討
• シロスタゾールによる副腎髄質ホルモンの分泌抑制作用
• 血管輪3症例の検討 : 日本循環器学会第54回中国・四国地方会
• 医学部学生に対する臨床試験教育の試み
• P366 成熟ラット単離心筋細胞からのカルシウム流出に及ぼす外因性ATPの効果及び流出機構
• 強心配糖体の培養ウシ副腎クロマフィン細胞におけるカテコールアミン生合成に対する影響
• 13P-7-36 Cardiospermum halicacabum L. 抽出成分による培養副腎髄質クロマフィン細胞からのカテコールアミン分泌作用
• サプリメントのEBM
• FRS-026 HIF-1α in T cells pathway plays a crucial role in the progression of arteriosclerosis(Novel Mechanisms in Atherosclerosis (IHD),Featured Research Session,The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
• Big Mitogen-Activated Protein Kinase 1 (BMK1)/Extracellular Signal Regulated Kinase 5 (ERK5) Is Involved in Platelet-Derived Growth Factor (PDGF)-Induced Vascular Smooth Muscle Cell Migration
• 抗酸化フラボノイドとアルドステロン拮抗薬の動脈硬化抑制作用
• The Novel Src Kinase Inhibitor M475271 Inhibits VEGF-Induced Vascular Endothelial-Cadherin and β-Catenin Phosphorylation but Increases Their Association
• Calcium and Reactive Oxygen Species Mediated Zn^-Induced Apoptosis in PC12 Cells
• インスリン抵抗性による血管障害の細胞内情報伝達機構
• OJ-211 HIF-ARNT Transcriptional System in T Cells Has a Pivotal Role in Vascular Inflammation and Remodeling(Atherosclerosis, basic-2 (H) OJ36,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
• 抗酸化薬の動脈硬化予防効果 : in vitroでのebselenの作用とin vivoでの経口亜硝酸の作用
• A Novel Src Kinase Inhibitor, M475271, Inhibits VEGF-Induced Human Umbilical Vein Endothelial Cell Proliferation and Migration
• Malfunction of Vascular Control in Lifestyle-Related Diseases : Formation of Systemic Hemoglobin-Nitric Oxide Complex (HbNO) From Dietary Nitrite
• S12-4 Zinc-induced cytotoxicity in PC12 cells(SYMPOSIUM 12: OXIDATIVE STRESS AND ORGAN DAMAGE)(Proceedings of the 31st Annual Meeting)
• Antioxidant Effects of Stereoisomers of N-Acetylcysteine (NAC), L-NAC and D-NAC, on Angiotensin II-Stimulated MAP Kinase Activation and Vascular Smooth Muscle Cell Proliferation
• Dual Effects of Endothelin-1 (1-31) : Induction of Mesangial Cell Migration and Facilitation of Monocyte Recruitment through Monocyte Chemoattractant Protein-1 Production by Mesangial Cells
• The Reaction Rate of Edaravone (3-Methyl-1-phenyl-2-pyrazolin-5-one (MCI-186)) with Hydroxyl Radical
• 臨床分子内分泌学 (1) : エンドセリン-心筋障害作用
• New Methods to Evaluate Endothelial Function : Evaluation of Endothelial Function by Hemoglobin-Nitric Oxide Complex Using Electron Paramagnetic Resonance Spectroscopy
• Stress and Vascular Responses: Atheroprotective Effect of Laminar Fluid Shear Stress in Endothelial Cells: Possible Role of Mitogen-Activated Protein Kinases
• R-51 Budd-Chiari 症候群に対する直視下肝部下大静脈パッチ拡大術(第50回日本消化器外科学会総会)
• ファロー四徴症を伴った完全型心内膜床欠損症症例の1治験例 : 日本循環器学会第58回中国・四国地方会
• 共通房室弁閉鎖不全により生後3ケ月時に弁置換術を要したDORV, hypoplastic LV症例 : 日本循環器学会第55回中国・四国地方会
• D18 新生児開心術 最近5年間の成績と適応拡大
• D17 当科における新生児期開心術症例の成績と予後
• PJ-070 Exaggerated Atherosclerosis in Heparin Cofactor II-Deficient ApoE Knockout Mice(Atherosclerosis, basic-8, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• OJ-216 Acceleration of Angiotensin II-Induced Coronary Artery Remodeling in Androgen Receptor Knockout Male Mice(Atherosclerosis, basic-2 (H) OJ36,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Soci
• OE-127 Androgen-Androgen Receptor System Counteracts Doxorubicin-Induced Cardiotoxicity through Attenuating Oxidative Stress-Induced Mitochondrial Damage in Murine Male Heart(Heart failure, basic-1 (M) OE22,Oral Presentation (English),The 70th Anniversary
• Androgen Receptor Gene Knockout Male Mice Exhibit Exacerbated Cardiotoxicity and Increased Mortality by Doxorubicin Administration(Cardiac Function, Basic/Clinical 1 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• Arterial Cuff Injury Causes Enhanced Neointimal Formation and Increased Adventitial Area in Heterozygous Heparin Cofactor II Deficient Mice(Atherosclerosis, Basic 1 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• PJ-359 Impaired Cardiac Hypertrophic Response and Exacerbated Cardiac Fibrosis in Angiotensin Il-Loaded Male Mice Lacking Androgen Receptor(Molecular Biology, Myocardium 1 (M) : PJ60)(Poster Session (Japanese))
• 三心房心 (Lucas-Schmidt II A型) に対する新生児期の1根治術症例(日本循環器学会 第57回中国・四国地方会)
• Antioxidant Effects of Photodegradation Product of Nifedipine
• 人工血管感染に対する再手術症例の検討
• 摘出ラット虚血再灌流心でのNa^+/H^+交換機構阻害薬,アミロライドの心筋保護効果 : 再灌流早期及び後期でのNa^+/H^+, Na^+/Ca^交換機構の関与
• 高血圧患者における血中硫酸抱合型ドーパミンの生理的意義
• 0372 急性心不全時の血中ドーパミン硫酸抱合型の変動並びに開心術後の塩酸ドカルパミン投与が抱合型ドーパミン形成に及ぼす影響について
• 小児開心術症例における血中遊離型および硫酸抱合型カテコールアミンの変動 : ファロー四徴症とVSD症例での検討
• Retroperitoneal lipomatous angiomyolipoma associated with amyloid deposition masquerading as well-differentiated liposarcoma
• Subependymoma of the spinal cord and review of the literature
• Effect of Endothelin-1 (1-31) on Human Mesangial Cell Proliferation
• Comparison of the Effects of Endothelin-1, -2 and -3 (1-31) on Changes in [Ca^]_i in Human Coronary Artery Smooth Muscle Cells
• 新しいα-, β-blocker, carvedilolのカテコールアミン放出に対する影響 : 培養クロマフィン細胞を用いての検索 : 日本循環器学会第55回中国・四国地方会
• 大動脈冠状動脈バイパス術後の心房細動発生症例の検討
• Plasma Levels of Free and Sulfoconjugated Catecholamines in Patients with Atherosclerosis
• Changes in Plasma Free and Sulfoconjugated Catecholamines during the Perioperative Period of Cardiac Surgery : Effect of Continuous Infusion of Dopamine
• 両側頚動脈閉塞と寒冷凝集素陽性を示した心筋梗塞後狭心症に対するCABG症例 : 日本循環器学会第60回中国・四国地方会
• 肺動脈閉鎖を伴ったFallot四徴症に対するValved pericardial rollを用いたRastelli型手術の2症例 : 日本循環器学会第60回中国・四国地方会
• 腎微小循環
• Participation of GABAergic and Histaminergic Systems in Inhibiting Amygdaloid Kindled Seizures
• Effect of angiotensin II on iron-transporting protein expression and subsequent intracellular labile iron concentration in human glomerular endothelial cells
• Adiponectin inhibits insulin-like growth factor-1-induced cell migration by the suppression of extracellular signal-regulated kinase 1/2 activation, but not Akt in vascular smooth muscle cells
• Quercetin Glucuronide Inhibits Cell Migration and Proliferation by Platelet-Derived Growth Factor in Vascular Smooth Muscle Cells
• Drug Discovery for Overcoming Chronic Kidney Disease (CKD) : Development of Drugs on Endothelial Cell Protection for Overcoming CKD
• Stress and Vascular Responses: Preface
• Inhomogeneity Correction in Radiotherapy for Lung Cancer in Multicenter Clinical Trials
• Radiation Pneumonitis following Multi-Field Radiation Therapy
• Patterns of Recurrence after Complete Remission with Definitive Radiotherapy in the Treatment of Malignant Glioma
• Phase II Study of Concurrent Chemoradiotherapy with Use of Uneven Fractionation for the Treatment of Glioblastoma
• Effects of an Antihypertensive Vasodilator, Pinacidil, on Regional Blood Flow in Conscious Spontaneously Hypertensive Rats
• A Long-lived o-Semiquinone Radical Anion is Formed from N-β-alanyl-5-S-glutathionyl-3,4-dihydroxyphenylalanine (5-S-GAD), an Insect-derived Antibacterial Substance
• Effects of Angiotensin II Type 1 Receptor Blockade on the Systemic Blood Nitric Oxide Dynamics in N^ω-Nitro-L-Arginine Methyl Ester-Treated Rats
• Phase I study of weekly cisplatin, vinorelbine, and concurrent thoracic radiation therapy in patients with locally advanced non-small-cell lung cancer
• A Single Institutional Subset Analysis of the WJLCG Study Comparing Concurrent and Sequential Chemoradiotherapy for Stage III Non-small-cell Lung Cancer
• Age-related endothelium-dependent vascular relaxation in rat thoracic aorta in response to colforsin
• Comparison of Antibacterial Activity of Fluoroquinolones with Their Sucralfate-complexes against Clinically-isolated Bacteria
• Comparison of the Protective Effect of N-Acetylcysteine by Different Treatments on Rat Myocardial Ischemia-Reperfusion Injury
• Stromal cells in hemangioblastoma : Neuroectodermal differentiation and morphological similarities to ependymoma
• Pharmacology in Health Food:Metabolism of Quercetin In Vivo and Its Protective Effect Against Arteriosclerosis
• Pathophysiological Response to Hypoxia — From the Molecular Mechanisms of Malady to Drug Discovery:Inflammatory Responses of Hypoxia-Inducible Factor 1α (HIF-1α) in T Cells Observed in Development of Vascular Remodeling
• Effect of Moderately Increased Intrapelvic Pressure on Renal Tissue Pressure and Vasopressin Release in Rabbits
• Effect of Lithium Carbonate Administration Singly or in Combination with Some Psychotropic Drugs on the Radioiodide Uptake by Mouse Thyroid
• Increased Plasma Dipeptidyl Peptidase IV (DPP IV) Activity and Decreased DPP IV Activity of Visceral But Not Subcutaneous Adipose Tissue in Impaired Glucose Tolerance Rats Induced by High-Fat or High-Sucrose Diet(Miscellaneous)
• Changes in Plasma Free and Sulfoconjugated Dopamine in Patients with Congenital Heart Disease who Underwent Cardiac Operation
• Physiological Significance of Plasma Sulfoconjugated Donamine : Experimental and Clinical Studies
• Electron Paramagnetic Resonance Study on Free Radical Scavenging and/or Generating Activity of Dopamine-4-O-sulfate
• Possible role of bradykinin on stimulus-secretion coupling in adrenal chromaffin cells
• Antioxidants Inhibit JNK and p38 MAPK Activation but not ERK 1/2 Activation by Angiotensin II in Rat Aortic Smooth Muscle Cells
• Accumulation of β-amyloid precursor protein in amyotrophic lateral sclerosis : relationship with fast transport abnormalities
• New Methods to Evaluate Endothelial Function : Preface
• Effects of Prolonged Treatment with β-Adrenoceptor Antagonist, Carteolol on Systemic and Regional Hemodynamics in Stroke-Prone Spontaneously Hypertensive Rats
• Functional restoration of endothelial cells of the cryopreserved heart valve
• Pharmacology in Health Food : Metabolism of Quercetin In Vivo and Its Protective Effect Against Arteriosclerosis
• Pathophysiological Response to Hypoxia-From the Molecular Mechanisms of Malady to Drug Discovery : Inflammatory Responses of Hypoxia-Inducible Factor 1α (HIF-1α) in T Cells Observed in Development of Vascular Remodeling
• Signal transduction of reactive oxygen species and mitogen-activated protein kinases in cardiovascular disease
• 閉塞性睡眠時無呼吸と心血管病

もっと見る 閉じる

スポンサーリンク