The Reaction Rate of Edaravone (3-Methyl-1-phenyl-2-pyrazolin-5-one (MCI-186)) with Hydroxyl Radical
スポンサーリンク
概要
- 論文の詳細を見る
The pyrazoline derivative edaravone is a potent hydroxyl radical scavenger that has been approved for attenuation of brain damage caused by ischemia-reperfusion. In the present work, we first determined the rate constant, k_r, at which edaravone scavenges radicals generated by a Fenton reaction in aqueous solution in the presence of the spin trap agent, 5,5-dimethyl-l-pyrroline-N-oxide (DMPO), which competed with edaravone. We detected the edaravone radicals in the process of hydroxyl radical scavenging and found that edaravone reacts with hydroxyl radical around the diffusion limit (k_r=3.0 × lO^<10>M^<-1>S^<-1>). The EPR (electron paramagnetic resonance) spectrum of the edaravone radical was observed by oxidation with a horseradish peroxidase-hydrogen peroxide system using the fast-flow method. This radical species is unstable and changed to another radical species with time. In addition, it was found that edaravone consumed molecular oxygen when it was oxidized by horseradish peroxidase (HRP)-H_2O_2 system, and that edaravone was capable of providing two electrons to the electrophiles. The possible mechanisms for oxidation of edaravone were investigated from these findings.
- 社団法人日本薬学会の論文
- 2004-02-01
著者
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吉栖 正典
奈良県立医科大学 薬理学講座
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Tamaki Toshiaki
Department of Pharmacology, IHBS, the University of TOKUSHIMA Graduate school
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Yoshizumi Masanori
Department of Pharmacology, Nara Medical University
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TSUCHIYA Koichiro
Department of Pharmacology, The University of Tokushima Graduate School of Medical Sciences
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ABE Shinji
Department of Clinical Pharmacy, Tokushima University Hospital
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OKAMOTO Masumi
Department of Pharmacology, Institute of Health Biosciences, University of Tokushima Graduate School
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HOUCHI Hitoshi
Department of Pharmacy, the University of Tokushima School of Medicine
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KIRIMA Kazuyoshi
Department of Pharmacology, The University of Tokushima School of Medicine
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HASEGAWA Toyoshi
Department of Pharmacology, The University of Tokushima School of Medicine
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Hasegawa Toyoshi
Department Of Pharmacology The University Of Tokushima School Of Medicine
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Abe S
Department Of Clinical Pharmacy Tokushima University Hospital
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Tamaki T
Department Of Pharmacology The Institute Of Health Bioscience The University Of Tokushima Graduate S
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Houchi H
Univ. Tokushima School Of Medicine Tokushima Jpn
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Houchi Hitoshi
Dep. Of Pharmacy Kagawa Univ. Hospital
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Houchi Hitoshi
Department Of Pharmacy The University Of Tokushima School Of Medicine
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Houchi Hitoshi
Department Of Pharmacology The University Of Tokushima School Of Medicine
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Houchi Hitoshi
Department Of Pharmacology Tokushima University School Of Medicine
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Okamoto M
Department Of Pharmacology The University Of Tokushima School Of Medicine
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Houchi Hitoshi
Departments Of Pharmacology The University Of Tokushima School Of Medicine
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Okamoto Masumi
Department Of Pharmacology The University Of Tokushima School Of Medicine
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岡本 麻衣子
城西大学
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Tamaki Toshiaki
The Department Of Pharmacology Kagawa Medical School
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Tamaki Toshiaki
Department Of Pharmacology Kagawa Medical School
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Kirima Kazuyoshi
Department Of Clinical Pharmacy The Institute Of Health Bioscience The University Of Tokushima Gradu
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Tsuchiya Koichiro
Department Of Clinical Pharmacology Institute Of Health Biosciences The University Of Tokushima Grad
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Yoshizumi Masanori
Dep. Of Pharmacology Nara Medical Univ. School Of Medicine Jpn
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Tamaki T
Department Of Molecular Engineering National Institute Of Materials And Chemical Research
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Hasegawa T
Department Of Agricultural Chemistry Tokyo University Of Agriculture
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Houchi H
Department Of Pharmacy The University Of Tokushima School Of Medicine
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Yoshizumi Masanori
Department Of Pharmacology Nara Medical University School Of Medicine
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Yosizumi Masanori
Department Of Pharmacology The University Of Tokushima School Of Medicine
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Okamoto M
Department Of Applied And Bioapplied Chemistry Graduate School Of Engineering Osaka City University
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Kitaichi T
Department Of Cardiovascular Surgery The University Of Tokushima Graduate School Of Health Bioscienc
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Abe Shinji
Department Of Clinical Pharmacy Tokushima University Hospital
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Kitaichi T
Department Of Cardiovascular Surgery The University Of Tokushima Graduate School Of Health Bioscienc
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Takeichi Toshiaki
Department Of Internal Medicine Health Insurance Naruto Hospital
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Yoshizumi M
Department of Cardiology and Department of Cardiovascular Surgery, Kobe General Hospital
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Tsuchiya Koichiro
Department Of Cardiovascular Surgery The University Of Tokushima Graduate School Of Health Bioscienc
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Abe Shinji
Department of Biochemistry and Chemical Engineering, Tohoku University
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