Erythroid Recovery Affects Tacrolimus Levels after Engraftment during Stem Cell Transplantation
スポンサーリンク
概要
- 論文の詳細を見る
Tacrolimus is commonly used in stem-cell transplants (SCT) for prophylaxis of graft-versus-host disease and is continuously administered throughout transplantation. The dose of tacrolimus is frequently decreased to maintain a desired concentration during the recovery of hemocytes after engraftment. If parameters which affect tacrolimus clearance are identified, it is of clinical use to estimate concentrations and aid dosing. The objective of this study was to identify which hematologic parameters affect tacrolimus clearance. Seventeen consecutive Japanese patients with hematological malignancies who received allogeneic SCT between March 2004 and January 2007 were enrolled in this study. Their steady-state concentrations were routinely measured and standardized as the concentration/dose (C/D) ratio ((ng/mL)/(mg/kg/d)). Multivariate analysis was performed to identify which hemocyte parameters affected the C/D ratio. Of the 13 patients, gradual dose reduction was required to combat elevated tacrolimus concentrations. The mean post-engraftment C/D ratio was higher than the pre-engraftment C/D ratio in each patient. The mean C/D ratio for all patients after engraftment was 1.56-fold higher (p=0.00004, range: 1.04–3.03) than that before engraftment. The variation ratio was calculated by dividing the C/D ratio by that on the engraftment day. Multivariate analysis revealed that the reticulocyte (RET) level (×103 count/µL) was the sole parameter influencing this ratio, and both parameters were expressed as: Variation ratio=0.004×RET+1.0. RET recovery of patients could influence the C/D ratio and tacrolimus clearance was affected by recipient original red blood cells, but not that of transfused red blood cells.
著者
-
IMATAKI Osamu
Division of Hematology, Department of Internal Medicine, Faculty of Medicine, Kagawa University
-
Imataki Osamu
Division Of Hematology Department Of Internal Medicine Faculty Of Medicine Kagawa University
-
Houchi Hitoshi
Department Of Pharmacology The University Of Tokushima School Of Medicine
-
Ohnishi Hiroaki
Division Of Hematology Department Of Internal Medicine Faculty Of Medicine Kagawa University
-
Fukuoka Noriyasu
Department Of Hospital Pharmacy Kagawa Medical School
-
Tanaka Hiroaki
Department Of Pharmacy Kagawa University Hospital
-
Tanaka Hiroaki
Department Of Biology Aichi University Of Education
-
Tani Kumiko
Department of Pharmacy, Kagawa University Hospital
-
IMATAKI Osamu
Division of Endocrinology and Metabolism, Hematology, Rheumatology and Respiratory Medicine, Department of Internal Medicine, Kagawa University
関連論文
- Fludarabine and melphalan conditioning with tacrolimus as GVHD prophylaxis for allogeneic stem cell transplant recipients is an effective reduced-intensity combination regimen compared to the conventional regimen
- Dual Effects of Endothelin-1 (1-31) : Induction of Mesangial Cell Migration and Facilitation of Monocyte Recruitment through Monocyte Chemoattractant Protein-1 Production by Mesangial Cells
- The Reaction Rate of Edaravone (3-Methyl-1-phenyl-2-pyrazolin-5-one (MCI-186)) with Hydroxyl Radical
- Effect of Endothelin-1 (1-31) on Human Mesangial Cell Proliferation
- Comparison of the Effects of Endothelin-1, -2 and -3 (1-31) on Changes in [Ca^]_i in Human Coronary Artery Smooth Muscle Cells
- Plasma Levels of Free and Sulfoconjugated Catecholamines in Patients with Atherosclerosis
- Changes in Plasma Free and Sulfoconjugated Catecholamines during the Perioperative Period of Cardiac Surgery : Effect of Continuous Infusion of Dopamine
- A Novel Activity of Na^+ Channel Blockers to Inhibit Proteasomal Degradation of Kv1.5 Channels
- Plasma Free and Sulfoconjugated Dopamine before and after a Half-Marathon
- A Novel Activity of a Na^+ Channel Blocker to Inhibit Proteasomal Degradation of Kir6.2 Channel and Increase Cardiac K_ Channels
- Excessive Purine Degradation during Semi-ischemic Forearm Test in Patients with Diabetes Mellitus
- Effect of iron chelator deferasirox on chronic anemia and thrombocytopenia in a transfusion-dependent patient with myelodysplastic syndrome
- EXERCISE TRAINING AUGMENTS CARDIOPULMONARY BAROREFLEX CONTROL OF FOREARM VASCULAR RESISTANCE IN MIDDLE-AGED SUBJECTS
- PE-110 The Vertical Dilatation of Left Atrium in Patients with Atrial Fibrillation Had a Rule(Arrhythmia, diagnosis/pathophysiology/EPS-07, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- OE-152 The Electrophysiological and Anatomical Characteristics of the Myocardial Free Area Located in Right Atrium-Inferior Vena Cava Junction(Arrhythmia, diagnosis/pathophysiology/EPS-02, The 71st Annual Scientific Meeting of the Japanese Circulation Soc
- PE-250 The Intra-atrial Conduction Disturbance in Brugada Syndrome Patients with Atrial Fibrillation(ECG/Body surface potential mapping/Holter-5 (A) PE42,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation S
- PE-136 The Influence of the sub-Eustachian Pouch on the Cavotricuspid Isthmus Ablation(Arrhythmia, diagnosis/pathophysiology/EPS-8 (A) PE23,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- OJ-397 Anatomical Characteristics of Mitral Isthmus in Japanese(Arrhythmia, diagnosis/pathophysiology/EPS-5 (A) OJ67,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- OJ-034 Heat Shock Protein (HSP) 70 and Its Inducer Can Stabilize Kv1.5 Channel Protein(Arrhythmia, basic-2 (A) OJ6,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- Comparison of Antibacterial Activity of Fluoroquinolones with Their Sucralfate-complexes against Clinically-isolated Bacteria
- Generation of mature dendritic cells fully capable of T helper type 1 polarization using OK-432 combined with prostaglandin E_2
- Lineage switch from precursor B cell acute lymphoblastic leukemia to acute monocytic leukemia at relapse
- Automated sampling system for long-term monitoring of nitrous oxide and methane fluxes from soils(Environment)
- Marked increase of normal blast morphologically mimicking leukemic clone in acute lymphoblastic leukemia patient following G-CSF therapy
- Electrical Properties of 100 nm Pitch Cr/Au Fine Electrodes with 40 nm Width on GaInAs
- New Electrocardiographic Criteria to Distinguish between Slow/Slow Atrioventricular Nodal Reentrant Tachycardia and Atrioventricular Reentrant Tachycardia Using Postroseptal Accessory Pathway(Arrhythmia, Diagnosis/Pathophysiology/EPS 11 (A), The 69th Annu
- Long-term Observation of the Patinets with Sinus Node Dysfunction Treated with Single Chamber Atrial Pacing(Arrhythmia, Non-pharmacological Therapy 2 (A), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Software Reliability Measurement with Prior-Information on Initial Fault Content
- Temperature-Independent Narrow-Band Optical Filter by an Athermal Waveguide
- Influence of Coadministered Antiepileptic Drugs on Serum Phenobarbital Concentrations in Epileptic Patients : Quantitative Analysis Based on a Suitable Transforming Factor(Biopharmacy)
- Influence of Coadministered Antiepileptic Drugs on Serum Zonisamide Concentrations in Epileptic Patients : Quantitative Analysis Based on Suitable Transforming Factor (Biopharmacy)
- Advantage of Extracellular Water Volume for the Relation between Serum Carbamazepine Concentration and Transformed Daily Dose
- Factors Influencing the Serum Concentration of Antiepileptic Drugs : Relationship between the Serum Valproic Acid Concentration and Daily Dose in Epileptic Patients
- Factors Influencing the Serum Concentration of Antiepileptic Drugs : Effects of Concomitant Antiepileptic Drugs on the Serum Valproic Acid Concentration in Epileptic Patients
- Visual disturbance comorbid with hallucination caused by voriconazole in the Japanese population
- Change of the Blood Concentration of Tacrolimus after the Switch from Fluconazole to Voriconazole in Patients Receiving Allogeneic Hematopoietic Stem Cell Transplantation(Biopharmacy)
- Changes in Plasma Free and Sulfoconjugated Dopamine in Patients with Congenital Heart Disease who Underwent Cardiac Operation
- Physiological Significance of Plasma Sulfoconjugated Donamine : Experimental and Clinical Studies
- Peritoneal pharmacokinetics of cefepime in laparotomy patients with inflammatory bowel disease, and dosage considerations for surgical intra-abdominal infections based on pharmacodynamic assessment
- Silylcarbene-to-Silene Rearrangement : Stable 1,2-Dihydrosilenes in Solution via the Silylcarbene Route
- Multiple Ileal polyps associated with gastrointestinal perforation in a 2-day-old neonate
- On the Mechanics and Physics in the Nano-Indentation of Silicon Monocrystals
- Electron Paramagnetic Resonance Study on Free Radical Scavenging and/or Generating Activity of Dopamine-4-O-sulfate
- Kinetics of cadmium nitrate in serum, bile, and urine after single intravenous injection of toxic doses (特集 臨床における亜鉛の有効性の探索)
- -0136-RELATIONSHIP OF ALCOHOL CONSUMPTION TO BLOOD PRESSURE AND SERUM LIPIDS
- A case of split notochord syndrome with congenital ileal atresia, the total absence of a colon, and a dorsal enteric cyst communicating to the retroperitoneal isolated ceca with a vesical fistula
- Pituitary Adenylate Cyclase-Activating Polypeptide Stimulates the Synthesis of Dopamine in Cultured Bovine Adrenal Chromaffin Cells
- Adsorption of Bradyrhizobium japonicum and Root Hair Curling in Non-Nodulating (rj_1 rj_1) Soybean Plant
- 174. Effects of training at 50% V^.o_2max for 60min in active college men
- Double-Hit Lymphoma at Second Relapse of Burkitt-Like Lymphoma : A Case Report
- 2E-04 The effect of regularly exercise on neutrophil function and NK cell rate in elderly men and women.
- Thoracic Lymphangiomatosis with Massive Chylothorax After a Tumor Biopsy and with Disseminated Intravenous Coagulation-Lymphoscintigraphy, an Alternative Minimally Invasive Imaging Technique : Report of a Case
- Heuristic Instruction Scheduling Algorithm Using Available Distance for Partial Forwarding Processor
- Kinetic Studies on Cytosine Arabinoside Permeation through the Egg Phosphatidylcholine Liposomal Membrane
- Effect of Mild Aerobic Exercise on Lipid and Apolipoprotein Levels in Patients with Essential Hypertension
- The Role of Exercise Physical Activity in Varying the Total Energy Expenditure in Healthy Japanese Men 30 to 69 Years of Age
- Validation of Three Alternative Methods to Measure Total Energy Expenditure against the Doubly Labeled Water Method for Older Japanese Men
- Identification of HLA-A^*2402-restricted epitope peptide derived from ERas oncogene expressed in human scirrhous gastric cancer
- Field-Ion Microscopic Observation of Surface Silicide Formation and Substrate Metal Interfaces
- Significant lowering of plasma ghrelin but not des-acyl ghrelin in response to acute exercise in men
- The Science and Technology Mobilization System in Imperial Japan(Science, War, and Colonization in East Asia)
- Acute Leukemia of Ambiguous Lineage, Biphenotype, without CD34, TdT or TCR-rearrangement
- Hepatitis B Reactivation in a Multiple Myeloma Patient with Resolved Hepatitis B Infection during Bortezomib Therapy : Case Report
- Erythroid Recovery Affects Tacrolimus Levels after Engraftment during Stem Cell Transplantation
- Leukemic Presentation of ALK-negative Anaplastic Large Cell Lymphoma in a Patient with Myelodysplastic Syndrome
- Acute myeloid leukemia in clinical practice : a retrospective population-based cohort study in Miyazaki Prefecture, Japan
- Rail Gap Switch Using Porous Metal as Electrode
- Limited Sampling Strategy for the Estimation of Mycophenolic Acid Area Under the Concentration-Time Curve Treated in Japanese Living-Related Renal Transplant Recipients with Concomitant Extended-Release Tacrolimus
- Effects of Angiotensin II AT1–Receptor Blockade on High Fat Diet–Induced Vascular Oxidative Stress and Endothelial Dysfunction in Dahl Salt-Sensitive Rats
- Occurrence of lymphoplasmacytic lymphoma 6 years after amelioration of primary cold agglutinin disease by rituximab therapy
- Excessive Purine Degradation druing Semi-ischemic Forearm Test in Patients with Diabetes Mellitus
- Portal Biliopathy Diagnosed Using Color Doppler and Contrast-enhanced Ultrasound
- Idebenone Inhibits Catecholamine Secretion through Its Blocking Action on Ca2+ Channels in Cultured Adrenal Chromaffin Cells.
- Inhibitory action of hydralazine on catecholamine-synthesizing enzymes prepared from bovine adrenal medulla.
- Pancytopenia Complicated with Peripheral Neuropathy Due to Copper Deficiency: Clinical Diagnostic Review
- Effect of nifedipine, dilazep, dinitrates and propranolol on blood lactate accumulation during intensive graded exercise testing in healthy young subjects.
- Secondary Neurolymphomatosis Detected by Whole-Body Diffusion-Weighted Magnetic Resonance Imaging :A Case Report
- Optimal Timing of a Second-Look Operation for Advanced Epithelial Ovarian Cancer.
- Increase in cyclic AMP level and stimulation of catecholamine synthesis in isolated bovine adrenal medullary cells caused by forskolin.
- Stimulatory Effect of Pituitary Adenylate Cyclase-Activating Polypeptide on Catecholamine Synthesis in Cultured Bovine Adrenal Chromaffin Cells: Involvements of Tyrosine Hydroxylase Phosphorylation Caused by Ca2+ Influx and cAMP.
- Effects of Angiotensin II AT_1-Receptor Blockade on High Fat Diet-Induced Vascular Oxidative Stress and Endothelial Dysfunction in Dahl Salt-Sensitive Rats
- Successful treatment by azacitidine therapy of intestinal Behcet's disease associated with myelodysplastic syndrome
- Cardiovascular Events in Pregnancy With Hypertrophic Cardiomyopathy