Pancytopenia Complicated with Peripheral Neuropathy Due to Copper Deficiency: Clinical Diagnostic Review
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概要
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Only a dozen cases of pancytopenia caused by copper deficiency have been reported. We report the case of an 81-year-old man who underwent total gastrectomy for gastric cancer. He received total parenteral nutrition without trace element supplementation for 6 months. Serum levels of copper and ceruloplasmin were low, but serum zinc was normal. The administration of copper into TPN led to rapid improvement in anemia and neutropenia. We review 11 previous cases of copper-deficient cytopenia, categorized into two groups according to etiology, and define the characteristic symptom of copper malabsorption caused by excess Zn as peripheral neuropathy.
- 社団法人 日本内科学会の論文
著者
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KITANAKA Akira
Department of Laboratory Medicine, Faculty of Medicine, Kagawa University
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TANAKA Terukazu
Environmental Health Sciences, Faculty of Medicine, Kagawa University
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Ishida Toshihiko
Department Of Electronic-mechanical Engineering Faculty Of Engineering Nagoya University
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Tanaka Terukazu
Environmental Health Sciences Faculty Of Medicine Kagawa University
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Ohnishi Hiroaki
Division Of Hematology Department Of Internal Medicine Faculty Of Medicine Kagawa University
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Kubota Yoshitsugu
Department Of Transfusion Medicine Faculty Of Medicine Kagawa University
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IMATAKI Osamu
Division of Hematology, Faculty of Medicine, Kagawa University
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IMATAKI Osamu
Division of Endocrinology and Metabolism, Hematology, Rheumatology and Respiratory Medicine, Department of Internal Medicine, Kagawa University
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KITANAKA Akira
Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki
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