Change of the Blood Concentration of Tacrolimus after the Switch from Fluconazole to Voriconazole in Patients Receiving Allogeneic Hematopoietic Stem Cell Transplantation(Biopharmacy)

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概要

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• The purpose of this study was to assess the impact by switching co-administered triazole antifungal agent from fluconazole (FCZ) to voriconazole (VCZ) on the blood concentration of tacrolimus (FK506) in patients receiving allogeneic hematopoietic stem cell transplantation. We performed a retrospective study presented as case reports. The blood concentration of FK506 was increased after the switch from FCZ to VCZ, resulting in increase of the concentration/dose (C/D) ratio of FK506. Thus, the mean C/D ratios of FK506 with oral administration was surprisingly increased over 4.5-fold after the switch. Therefore, it was necessary to reduce the FK506 dose when co-administered FCZ is switched to VCZ. We should be careful when interpreting the results of these case reports; however, in some patients, it is recommended that the dose of FK506 be reduced to one-fifth after the switch.

• 公益社団法人日本薬学会の論文
• 2006-12-01

著者

• ISHIDA Toshihiko

  Department of Internal Medicine, Faculty of Medicine, Kagawa University

• TAKIGUCHI Yoshiharu

  Department of Clinical Pharmacology, Subdivision of Clinical Pharmaceutical Sciences, Institute of H

• HOUCHI Hitoshi

  Department of Pharmacy, the University of Tokushima School of Medicine

• Houchi H

  Univ. Tokushima School Of Medicine Tokushima Jpn

• Houchi Hitoshi

  Dep. Of Pharmacy Kagawa Univ. Hospital

• Houchi Hitoshi

  Department Of Pharmacy The University Of Tokushima School Of Medicine

• Houchi Hitoshi

  Department Of Pharmacology The University Of Tokushima School Of Medicine

• Houchi Hitoshi

  Department Of Pharmacology Tokushima University School Of Medicine

• Tanaka Hiroaki

  Department of Cardiovascular Medicine, Tottori University Faculty of Medicine

• Ishida T

  Department Of Internal Medicine Faculty Of Medicine Kagawa University

• Ishida Toshihiko

  Department Of Electronic-mechanical Engineering Faculty Of Engineering Nagoya University

• Ishida Toshihiko

  Department Of Internal Medicine Division Of Endocrinology And Metabolism Hematology Rheumatology And

• Houchi Hitoshi

  Departments Of Pharmacology The University Of Tokushima School Of Medicine

• Ohnishi Hiroaki

  Department Of Internal Medicine Division Of Endocrinology And Metabolism Hematology Rheumatology And

• Ohnishi Hiroaki

  Department Of Earth And Space Science Graduate School Of Science Osaka University

• Tanaka Hiroaki

  Department Of Cardiovascular Medicine Tottori University Fuculty Of Medicine

• Kawazoe Hitoshi

  Department of Clinical Pharmacology, Institute of Health Biosciences, The University of Tokushima Gr

• FUKUOKA Noriyasu

  Department of Hospital Pharmacy, Kagawa University

• Takiguchi Yoshiharu

  Dep. Of Clinical Pharmacology Inst. Of Health Biosciences The Univ. Of Tokushima Graduate School

• Takiguchi Yoshiharu

  Department Of Clinical Pharmacology Institute Of Health Biosciences The University Of Tokushima Grad

• Kawazoe Hitoshi

  Department Of Pharmacy Kagawa University Hospital:department Of Clinical Pharmacology Graduate Schoo

• Fukuoka Noriyasu

  Department Of Pharmacy Kagawa University Hospital

• Fukuoka Noriyasu

  Department Of Hospital Pharmacy Kagawa Medical School

• Tanaka Hiroaki

  Department Of Pharmacy Kagawa University Hospital

• Tanaka Hiroaki

  Department Of Biology Aichi University Of Education

• Kawasaki Hiromi

  Department of Pharmacy, Kagawa University Hospital:Department of Clinical Pharmacology, Graduate School of Pharmaceutical Sciences, The University of Tokushima

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