Changes in Plasma Free and Sulfoconjugated Catecholamines during the Perioperative Period of Cardiac Surgery : Effect of Continuous Infusion of Dopamine
スポンサーリンク
概要
- 論文の詳細を見る
In orther to elucidate the pharmacological properties of the formation of sulfoconjugated catecholamines (CAs) in human plasma, we investigated the changes in the plasma levels of free and sulfoconjugated CA during the continous infusion of dopamine (DA; 4-6 μg/kg/min for 24 h, followed by 3-4 μg/kg/min for 48 h) in patients who had undergone cardiac surgery. The plasma level of free DA increased immediately after the start of the infusion and reached a plateau within 1 h at a level of about 2000 times the basal value. In the control patients who had received non-cardiac surgery without DA infusion, plasma-free DA increased only 5-fold after their operation.The plasma level of DA sulfate increased linearly for 24 h, to 48-fold of the basal value by DA infusion, whereas it showed only a 2-fold increased in the contorl patients. After 24 h, due to reduction of the infused DA dose, the level of free DA gardually decreased, whereas the level of DA sulfate remained elevated. The plasma levels of free adrenaline (Ad) and noradrenaline (NA) also increased during the DA infusion, but their levels reached a plateau within 1-2 h. Sulfoconjugated Ad and NA increased progressively until the tapering off of DA infusion. In the control patients, both free and conjugated Ad and NA showed transient increases over 12 h after surgery. These results suggest that sulfoconjugation plays a role in regulating the plasma levels of excess free CA, therby modifying the cardiovascular effects of circulating CA. Measurement of the increaes in plasma conjugated CA may be useful as an index of the increase in free CA in plasma due to the administration of an exogenous form or release of endogenous CA from the tissues.
- 社団法人日本薬学会の論文
- 1998-08-15
著者
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吉栖 正典
奈良県立医科大学 薬理学講座
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Tamaki Toshiaki
Department of Pharmacology, IHBS, the University of TOKUSHIMA Graduate school
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Yoshizumi Masanori
Department of Pharmacology, Nara Medical University
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TSUCHIYA Koichiro
Department of Pharmacology, The University of Tokushima Graduate School of Medical Sciences
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HOUCHI Hitoshi
Department of Pharmacy, the University of Tokushima School of Medicine
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Minakuchi Kazuo
Department Of Radiology Osaka Prefectural Medical Center For Respiratory And Allergic Diseases
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Ozawa Yuichi
徳島大学 薬理
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Ozawa Yuichi
Departments Of Pharmacy The University Of Tokushima School Of Medicine
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Ozawa Yuichi
Departments Of Pharmacology The University Of Tokushima School Of Medicine
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Ozawa Yuichi
徳島大学総合科学部
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Tamaki T
Department Of Pharmacology The Institute Of Health Bioscience The University Of Tokushima Graduate S
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Houchi H
Univ. Tokushima School Of Medicine Tokushima Jpn
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Houchi Hitoshi
Dep. Of Pharmacy Kagawa Univ. Hospital
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Houchi Hitoshi
Department Of Pharmacy The University Of Tokushima School Of Medicine
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Houchi Hitoshi
Department Of Pharmacology The University Of Tokushima School Of Medicine
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Houchi Hitoshi
Department Of Pharmacology Tokushima University School Of Medicine
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KITAGAWA Tetsuya
Cardiovascular Surgery, The University of Tokushima School of Medicine
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TANO Kazutoshi
Cardiovascular Surgery The University of Tokushima School of Medicine
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Minakuchi Kazuo
Department Of Clinical Pharmacy The Institute Of Health Bioscience The University Of Tokushima Gradu
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Minakuchi K
Osaka City Univ. Medical School Osaka Jpn
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Minakuchi Kazuo
Department Of Clinical Pharmacy Institute Of Health Biosciences The University Of Tokushima Graduate
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Houchi Hitoshi
Departments Of Pharmacology The University Of Tokushima School Of Medicine
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Tamaki Toshiaki
Department Of Pharmacology Kagawa Medical School
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Tsuchiya Koichiro
Department Of Clinical Pharmacology Institute Of Health Biosciences The University Of Tokushima Grad
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Yoshizumi Masanori
Dep. Of Pharmacology Nara Medical Univ. School Of Medicine Jpn
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Ozawa Yuichi
Department Of Pharmaceutical Sciences Tohoku University Hospital
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Kitagawa T
Department Of Cardiovascular Surgery Institute Of Health Biosciences University Of Tokushima Graduat
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Kitagawa Tetsuya
Department Of Cardiovascular Surgery Tokushima University School Of Medicine
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Tamura Katsuya
Divison Of Cardiology Health Insurance Naruto Hospital
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Yoshizumi Masanori
Department Of Pharmacology Nara Medical University School Of Medicine
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Yosizumi Masanori
Department Of Pharmacology The University Of Tokushima School Of Medicine
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Kitaichi T
Department Of Cardiovascular Surgery The University Of Tokushima Graduate School Of Health Bioscienc
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Takeichi Toshiaki
Department Of Internal Medicine Health Insurance Naruto Hospital
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Kitagawa Tetsuya
Department Of Cardiovascular Surgery The University Of Tokushima Graduate School Of Health Bioscienc
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Kitagawa Tetsuya
Cardiovascular Surgery The University Of Tokushima Graduate School Of Health Biosciences
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Kitagawa Tetsuya
Department Of Cardiovascular Surgery The University Of Tokushima Graduate School Of Health Bioscienc
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Tsuchiya Koichiro
Department Of Cardiovascular Surgery The University Of Tokushima Graduate School Of Health Bioscienc
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