Calcium and Reactive Oxygen Species Mediated Zn^<2+>-Induced Apoptosis in PC12 Cells
スポンサーリンク
概要
- 論文の詳細を見る
The release of excessive Zn2+ from presynaptic boutons into extracellular regions contributes to neuronal apoptotic events, which result in neuronal cell death. However, the mechanisms of Zn2+-induced neuronal cell death are still unclear. Therefore, we investigated the dynamics of intracellular Zn2+, calcium, and reactive oxygen species in PC12 cells. The addition of Zn2+ produced cell death in a concentration- and time-dependent manner. 45Ca2+ influx occurred just after the treatment with Zn2+, although subsequent hydroxyl radical (•OH) production did not begin until 3 h after Zn2+ exposure. •OH production was significantly attenuated in Ca2+-free medium or by L-type Ca2+ channel antagonist treatment, but it was independent of the intracellular Zn2+ content. Dantrolene treatment had no protective effects against Zn2+-induced cell death. Treatment with N-acetyl-<sc>L</sc>-cysteine blocked •OH generation and subsequent cell death. These data indicate that Ca2+ influx and subsequent •OH production are critical events in Zn2+-induced toxicity in PC12 cells.
- 社団法人 日本薬理学会の論文
- 2006-09-20
著者
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吉栖 正典
奈良県立医科大学 薬理学講座
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Tamaki Toshiaki
Department of Pharmacology, IHBS, the University of TOKUSHIMA Graduate school
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Yoshizumi Masanori
Department of Pharmacology, Nara Medical University
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ISHIZAWA Keisuke
Department of Pharmacology, The University of Tokushima Graduate School of Medical Sciences
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KAWAZOE Kazuyoshi
Department of Pharmacy, Tokushima University Hospital
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TSUCHIYA Koichiro
Department of Pharmacology, The University of Tokushima Graduate School of Medical Sciences
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OHNISHI Hideki
Department of Pharmacology, The University of Tokushima Graduate School, Institute of Health Bioscie
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KANEMATSU Yasuhisa
Department of Pharmacology, The University of Tokushima Graduate School, Institute of Health Bioscie
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ABE Shinji
Department of Clinical Pharmacy, Tokushima University Hospital
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TORII Mayumi
Department of Clinical Pharmacy, Tokushima University Hospital
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MINAKUCHI Kazuo
Department of Clinical Pharmacy, Tokushima University Hospital
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Ohnishi Hideki
Department Of Pharmacology Institute Of Health Biosciences The University Of Tokushima Graduate Scho
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Ohnishi Hideki
徳島大学 ヘルスバイオサイエンス研究部情報伝達薬理学
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Minakuchi Kazuo
Department Of Radiology Osaka Prefectural Medical Center For Respiratory And Allergic Diseases
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Abe S
Department Of Clinical Pharmacy Tokushima University Hospital
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Tamaki T
Department Of Pharmacology The Institute Of Health Bioscience The University Of Tokushima Graduate S
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Torii Mayumi
Department Of Clinical Pharmacy Tokushima University Hospital
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Minakuchi Kazuo
Department Of Clinical Pharmacy The Institute Of Health Bioscience The University Of Tokushima Gradu
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Minakuchi K
Osaka City Univ. Medical School Osaka Jpn
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Minakuchi Kazuo
Department Of Clinical Pharmacy Institute Of Health Biosciences The University Of Tokushima Graduate
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Tamaki Toshiaki
The Department Of Pharmacology Kagawa Medical School
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Tamaki Toshiaki
Department Of Pharmacology Kagawa Medical School
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Kirima Kazuyoshi
Department Of Clinical Pharmacy The Institute Of Health Bioscience The University Of Tokushima Gradu
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Ishizawa Keisuke
Department Of Pharmacology The Institute Of Health Bioscience The University Of Tokushima Graduate S
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Ishizawa Keisuke
Department Of Neurology Neurological Institute Tokyo Women's Medical College
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Tsuchiya Koichiro
Department Of Clinical Pharmacology Institute Of Health Biosciences The University Of Tokushima Grad
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Kawazoe Kazuyoshi
Department Of Clinical Pharmacy Institute Of Health Biosciences The University Of Tokushima Graduate
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Kanematsu Yasuhisa
Department Of Pharmacology Institute Of Health Biosciences The University Of Tokushima Graduate Scho
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Yoshizumi Masanori
Dep. Of Pharmacology Nara Medical Univ. School Of Medicine Jpn
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Kawai Yoshichika
Dep. Of Pharmacology The Inst. Of Health Bioscience The Univ. Of Tokushima
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Yoshizumi Masanori
Department Of Pharmacology Nara Medical University School Of Medicine
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Yosizumi Masanori
Department Of Pharmacology The University Of Tokushima School Of Medicine
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Kitaichi T
Department Of Cardiovascular Surgery The University Of Tokushima Graduate School Of Health Bioscienc
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Abe Shinji
Department Of Clinical Pharmacy Tokushima University Hospital
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Kitaichi T
Department Of Cardiovascular Surgery The University Of Tokushima Graduate School Of Health Bioscienc
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Takeichi Toshiaki
Department Of Internal Medicine Health Insurance Naruto Hospital
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Ishizawa Keisuke
Department Of Medical Pharmacology Institute Of Health Biosciences The University Of Tokushima Gradu
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Tsuchiya Koichiro
Department Of Cardiovascular Surgery The University Of Tokushima Graduate School Of Health Bioscienc
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Ohnishi Hideki
Department Of Gastroenterology And Hepatology Okayama University Graduate School Of Medicine Dentistry And Pharmaceutical Sciences
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Abe Shinji
Department of Biochemistry and Chemical Engineering, Tohoku University
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