Quercetin Glucuronide Inhibits Cell Migration and Proliferation by Platelet-Derived Growth Factor in Vascular Smooth Muscle Cells
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概要
- 論文の詳細を見る
Many epidemiologic studies have reported that dietary flavonoids provide protection against cardiovascular disease. Quercetin, a member of the bioflavonoids family, has been proposed to have anti-inflammatory, anti-atherogenic, and anti-hypertensive properties leading to the beneficial effects against cardiovascular diseases. Recent studies demonstrated that orally administered quercetin appeared in plasma as glucuronide-conjugated forms in rats and humans. Therefore, we examined the effect of chemically synthesized quercetin glucuronide on platelet-derived growth factor (PDGF)-induced cell migration and kinase activation in cultured rat aortic smooth muscle cells (RASMCs). PDGF-induced RASMC migration was inhibited by quercetin 3-O-β-<sc>D</sc>-glucuronide (Q3GA). Q3GA also attenuated PDGF-induced cell proliferation in RASMCs. PDGF activated extracellular-signal regulated kinase (ERK) 1/2, c-Jun N-terminal kinase (JNK), p38 mitogen-activated protein (MAP) kinase, and Akt in RASMCs. PDGF-induced JNK and Akt activations were suppressed by Q3GA, whereas ERK1/2 and p38 MAP kinase activations were not affected. We also confirmed that PDGF-induced JNK and Akt activations were inhibited by antioxidants, N-acetylcysteine and diphenyleneiodonium chloride, in RASMCs. These findings suggest Q3GA would be an active metabolite of quercetin in plasma and may possess preventing effects for cardiovascular diseases relevant to vascular smooth muscle cell disorders.
- 社団法人 日本薬理学会の論文
- 2009-02-20
著者
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Tomita Shuhei
Department Of Pharmacology The Institute Of Health Bioscience The University Of Tokushima Graduate S
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Tomita Shuhei
徳島大学 ヘルスバイオサイエンス研究部薬理学
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Tomita Shuhei
徳島大学 ヘルスバイオサイエンス研究部薬理学分野
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Tomita Shuhei
Division Of Experimental Immunology Institute For Genome Research The University Of Tokushima Gradua
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Tamaki Toshiaki
Department of Pharmacology, IHBS, the University of TOKUSHIMA Graduate school
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ISHIZAWA Keisuke
Department of Pharmacology, The University of Tokushima Graduate School of Medical Sciences
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KAWAZOE Kazuyoshi
Department of Pharmacy, Tokushima University Hospital
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TSUCHIYA Koichiro
Department of Pharmacology, The University of Tokushima Graduate School of Medical Sciences
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Minakuchi Kazuo
Department Of Radiology Osaka Prefectural Medical Center For Respiratory And Allergic Diseases
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Hamano Shuichi
Department of Pathological Science and Technology, The Institute of Health Bioscience, The Universit
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Izawa Ishizawa
Department Of Pharmacology The Institute Of Health Bioscience The University Of Tokushima Graduate S
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Tamaki T
Department Of Pharmacology The Institute Of Health Bioscience The University Of Tokushima Graduate S
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Minakuchi Kazuo
Department Of Clinical Pharmacy The Institute Of Health Bioscience The University Of Tokushima Gradu
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Minakuchi K
Osaka City Univ. Medical School Osaka Jpn
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Minakuchi Kazuo
Department Of Clinical Pharmacy Institute Of Health Biosciences The University Of Tokushima Graduate
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Izawa Yuki
Department Of Pharmacology The Institute Of Health Bioscience The University Of Tokushima Graduate S
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MOTOBAYASHI Yuki
Department of Pharmacology, The Institute of Health Bioscience, The University of Tokushima Graduate
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OHNISHI Sachiyo
Department of Clinical Pharmacy, The Institute of Health Bioscience, The University of Tokushima Gra
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Tamaki Toshiaki
The Department Of Pharmacology Kagawa Medical School
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Tamaki Toshiaki
Department Of Pharmacology Kagawa Medical School
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Kirima Kazuyoshi
Department Of Clinical Pharmacy The Institute Of Health Bioscience The University Of Tokushima Gradu
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Sugihara Takashi
Division Of Cardiovascular Medicine Tokushima University Hospital
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Ishizawa Keisuke
Department Of Pharmacology The Institute Of Health Bioscience The University Of Tokushima Graduate S
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Ishizawa Keisuke
Department Of Neurology Neurological Institute Tokyo Women's Medical College
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Tsuchiya Koichiro
Department Of Clinical Pharmacology Institute Of Health Biosciences The University Of Tokushima Grad
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Kawazoe Kazuyoshi
Department Of Clinical Pharmacy Institute Of Health Biosciences The University Of Tokushima Graduate
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Soeki Takeshi
Department Of Cardiovascular Medicine The University Of Tokushima
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Hamano Shuichi
Department Of Pharmacology The Institute Of Health Bioscience The University Of Tokushima Graduate S
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Izawa Y
Department Of Pharmacology The Institute Of Health Bioscience The University Of Tokushima Graduate S
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Ohnishi Sachiyo
Department Of Clinical Pharmacy The Institute Of Health Bioscience The University Of Tokushima Gradu
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Matsuda Yuko
Dep. Of Medical Pharmacology The Inst. Of Health Bioscience The Univ. Of Tokushima
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Kitaichi T
Department Of Cardiovascular Surgery The University Of Tokushima Graduate School Of Health Bioscienc
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Kitaichi T
Department Of Cardiovascular Surgery The University Of Tokushima Graduate School Of Health Bioscienc
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Motobayashi Yuki
Department Of Pharmacology The Institute Of Health Bioscience The University Of Tokushima Graduate S
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Takeichi Toshiaki
Department Of Internal Medicine Health Insurance Naruto Hospital
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Ishizawa Keisuke
Department Of Medical Pharmacology Institute Of Health Biosciences The University Of Tokushima Gradu
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Tsuchiya Koichiro
Department Of Cardiovascular Surgery The University Of Tokushima Graduate School Of Health Bioscienc
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Izawa-ishizawa Yuki
Department Of Pharmacology Institute Of Health Biosciences The University Of Tokushima Graduate School
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