Renal effects of leukotrienes C4 and D4 in anesthetized dogs.
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概要
- 論文の詳細を見る
We investigated the effects of leukotrienes (LTs) C<SUB>4</SUB> and D<SUB>4</SUB> on renal function and hemodynamics of dogs. LTC<SUB>4</SUB> (0.5 μg/min, infused into the renal artery), but not LTD<SUB>4</SUB> (1 μg/min), caused an increase in renal blood flow, urine flow, urinary excretion of sodium and potassium, and rate of free water reabsorption, with a concomitant rise in systemic blood pressure. Intrarenal infusion of LTC<SUB>4</SUB> under conditions of constant renal perfusion pressure induced no significant effect on renal blood flow or urine formation. Infusions or LTC<SUB>4</SUB> and LTD<SUB>4</SUB> into the renal artery induced no change in the release of prostaglandins, PGE<SUB>2</SUB>, PGF<SUB>2α</SUB>, 6-keto-PGF<SUB>1α</SUB> or thromboxane B<SUB>2</SUB> into renal venous blood. From these findings, we concluded that the renal effects of LTC<SUB>4</SUB> were secondary responses to a rise in systemic blood pressure.
- 公益社団法人 日本薬理学会の論文
著者
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Tamaki Toshiaki
Department Of Pharmacology Kagawa Medical School
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Abe Youichi
Department Of Pharmacology Kagawa Medical University
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Fujioka Shoji
Department Of Pharmacology Kagawa Medical School:second Department Of Internal Medicine Osaka City U
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Okahara Takeshi
Department Of Pharmacology Osaka City University Medical School
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Fukui Kiyoshi
Department Of Biochemistry National Cardiovascular Center Research Institute
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Iwao Hiroshi
Department Of Cardiovascular Medicine Akita University Graduate School Of Medicine
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